Navigation Links
Researchers find a new gene expression mechanism of PRRS virus
Date:5/12/2014

MANHATTAN, Kan. A collaborative study involving Kansas State University researchers has discovered a new gene expression mechanism in porcine reproductive and respiratory syndrome, or PRRS, virus an important swine pathogen that costs the U.S. pork industry more than $600 million a year. The discovery provides a new avenue for scientists to explore strategies to control and prevent the disease.

Ying Fang, Ph.D., associate professor of diagnostic medicine and pathobiology at Kansas State University, led a study that looked at the unique gene expression mechanism of the PRRS virus. She and colleagues found a new protein in the virus, nsp2TF, was generated through novel ribosomal frameshifting signals.

The research recently appeared in the Proceedings of the National Academy of Sciences, or PNAS, study, "Transactivation of programmed ribosomal frameshifting by a viral protein."

Fang conducted this study with her European collaborators, including Eric Snijder and his team members at Leiden University Medical Center in The Netherlands, and Andrew Firth, Ian Brierley and Brierley's lab members at the University of Cambridge. Yanhua Li, Fang's doctoral student in pathobiology, China, made important contributions to this study. Zhi Sun, Fang's former doctoral student, and Longchao Zhu, visiting scholars in diagnostic medicine and pathobiology in Fang's lab, also were involved in the study.

The study builds on a 2012 PNAS study Fang and her European collaborators conducted while she was at South Dakota State University. In it, researchers identified the nsp2TF protein in the PRRS virus. The protein is expressed through a new gene expression mechanism called -2 ribosomal frameshifting.

"Frameshifting occurs when a ribosome encounters a 'slippery' sequence and downstream signal in messenger RNA," Fang said. "This causes the ribosome to shift two nucleotides backward, which results in all the genetic codons downstre
'/>"/>

Contact: Ying Fang
yfang@k-state.edu
785-532-4452
Kansas State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers find a new gene expression mechanism of PRRS virus
(Date:8/20/2014)... Knoxville, research finds life can persist in a cold, ... of a team that examined waters and sediments from ... and found the extreme environment supports microbial ecosystems. ... and her colleagues has implications for life in other ... system. The findings are published in the current edition ...
(Date:8/20/2014)... fires are visible in in this image of the ... of these were most likely intentionally set in order ... a forest or stand of trees where the land ... deforestation include conversion of forestland to farms, ranches, or ... dark green of the Amazon Rainforest in the middle ...
(Date:8/20/2014)... Health has awarded the Oklahoma Medical Research Foundation a ... anthrax and the bacteria,s effects on humans. , ... his colleagues have studied the human immune response to ... Human Immunology. The original funding came soon after anthrax-laced ... of the terrorist attacks of Sept. 11, 2001. ...
Breaking Biology News(10 mins):University of Tennessee research uncovers subglacial life beneath Antarctic ice sheet 2$14.5 million grant awarded to continue anthrax studies 2
... an increased risk of long-term illness, not because of ... according to a study in the urology journal ... Radium Hospital at the University of Oslo found that ... than generally thought, because clinicians only report those that ...
... KONG, Oct. 15 /PRNewswire-Asia/ -- Futronic Technology Company,Limited, a global ... Windows Biometric Framework (WBF) Driver for its,USB fingerprint scanner has ... Windows 7, a new PC operating system that will be ... and it may be installed,through Windows Update later. , ...
... Hospital,s Weight Control and Diabetes Research Center (WCDRC) recently received ... totaling more than $12 million in funding that will ... treatment of obesity. Rena R. Wing, PhD, director ... behavior at The Warren Alpert Medical School of Brown University, ...
Cached Biology News:Treatment not testicular cancer poses greatest risk to survivors' long-term health 2Treatment not testicular cancer poses greatest risk to survivors' long-term health 3Futronic Windows 7 Biometric Framework Driver is Signed by Microsoft 2Miriam Hospital researcher receives more than $12 million to study weight control 2Miriam Hospital researcher receives more than $12 million to study weight control 3
(Date:8/21/2014)... , Aug. 21, 2014 Mathematic studies at ... Harvard University , and funded by the Jeffrey Epstein ... within tumors can be visually identified for elimination. These aggressive ... The study, which shows a topological map of what to ... in cancer research, for while tumor cells can be extracted ...
(Date:8/21/2014)... August 21, 2014 Pursuit Solutions ... optimization technology and services for Life Sciences sales ... Pharma’s Use of New Commercial Sales Models” by ... Analytics. , The article examines some innovative models ... are being tested in the pharmaceutical market. Robinson ...
(Date:8/21/2014)... 21, 2014 On Wednesday of last week ... use Redox Signaling molecules, became available for purchase in Australia ... "The way that RENU 28 works is, if you think ... of the rate of cellular renewal within your body. If ... of that rate of cellular renewal. What RENU 28 does ...
(Date:8/20/2014)... have succeeded in measuring vibrational motion of a single ... how vibration of a single molecule differs from the ... was performed at the University of California, Irvine, where ... works as a visiting fellow under professor Vartkess A. ... team was lead by Professor Eric O. Potma. The ...
Breaking Biology Technology:Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2RENU 28 Skin Care Now Available in Australia and New Zealand 2Seeing a molecule breathe 2
... BUCHS/AARAU, Switzerland, Feb. 2, 2012 Swisslog and JBT ... and manufacture state-of-the-art AGVs for hospitals. ... be jointly developed and marketed from 2013 onwards. The ... of logistics solutions for hospitals. JBT will supply all ...
... of the incredible strength of spider silk, the robust ... webs survive multiple tears and winds that exceed hurricane ... of spider webs with complex computer simulations has shown ... but on how the overall web design compensates for ...
... N.J., Feb. 1, 2012 Unigene Laboratories, Inc. ... the 2012 Drug Delivery Partnerships™ ("DDP") Innovation Award in ... 2011 clinical advances in the oral delivery of peptides.  ... voted on and selected by conference attendees, including leading ...
Cached Biology Technology:JBT Corporation and Swisslog Enter Into Partnership for Automated Guided Vehicles 2JBT Corporation and Swisslog Enter Into Partnership for Automated Guided Vehicles 3A spider web's strength lies in more than its silk 2A spider web's strength lies in more than its silk 3A spider web's strength lies in more than its silk 4Unigene Receives 2012 Drug Delivery Partnerships Industry Achievement Award 2Unigene Receives 2012 Drug Delivery Partnerships Industry Achievement Award 3Unigene Receives 2012 Drug Delivery Partnerships Industry Achievement Award 4Unigene Receives 2012 Drug Delivery Partnerships Industry Achievement Award 5
... The Experion Pro260 analysis kit for 10 ... to perform protein analysis with the Experion ... Pro260 microfluidic chips, 3 x 520 microliters ... microliters Pro260 ladder (10-260 kD), 400 microliters ...
Experion Pro260 chips are the microfluidic chips used to perform protein analysis with the Experion automated electrophoresis system. Each chip has the capacity to run 10 protein samples. Supplied as...
... discovery system miniaturizes, integrates and automates ... LabChip technology, the LabChip 3000 performs ... flow fashion. LabChip assays are separations-based, ... what is achievable in homogenous, well-based ...
... in the submicron range are part of ... and control of particle size is important ... can reliably detect the component populations in ... Particle Size Analyzer uses Photon Correlation Spectroscopy ...
Biology Products: