Navigation Links
Researchers find a missing component in effort to create primitive, synthetic cells
Date:11/28/2013

A team of Massachusetts General Hospital (MGH) investigators working to create "protocells" primitive synthetic cells consisting of a nucleic acid strand encased within a membrane-bound compartment have accomplished an important step towards their goal. In the November 28 issue of Science, the investigators describe a solution to what could have been a critical problem the potential incompatibility between a chemical requirement of RNA copying and the stability of the protocell membrane.

"For the first time, we've been able to do nonenzymatic RNA copying inside fatty acid vesicles," says Jack Szostak, PhD, of the MGH Department of Molecular Biology and the Center for Computational and Integrative Biology. "We've found a solution to a longstanding problem in the origin of cellular life: RNA copying chemistry requires the presence of the magnesium ion Mg2+, but high Mg2+ levels can break down the simple, fatty acid membranes that probably surrounded the first living cells."

Szostak's team has been working for more than a decade to understand how the first cells developed from a "primordial soup" of chemicals into living organisms capable of copying their genetic material and reproducing. Part of that work is developing a model protocell made from components probably present in the primitive Earth environment. They have made significant progress towards developing cell membranes from the kind of fatty acids that would have been abundant and naturally form themselves into bubble-like vesicles when concentrated in water. But the genetic component an RNA or DNA molecule capable of replication has been missing.

Since the primitive environment in which such cells could have developed would not have had the kind of complex enzymes that modern cells use in replicating nucleic acids, Szostak and lead author Katarzyna Adamala, PhD, then a graduate student in Szostak's lab, investigated whether simple chemical processes could
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... OXFORD, Conn. , July 7, 2015 NXT-ID, Inc. ... company focused on the growing mobile commerce market announces a revised ... airing this week. The commercial will air on CNBC in ... Los Angeles and San Francisco ... The commercial focuses on Wocket,s ability to replace all the ...
(Date:7/2/2015)... 2015 Fingerprint Cards has received an ... FPC1155 from the distributor World Peace Industrial Group (WPI), part ... Asia . Deliveries are planned to take ... used by smartphone manufacturers in Asia . ... communicated revenue guidance of approximately 2,200 MSEK for 2015. ...
(Date:6/29/2015)... Research and Markets( http://www.researchandmarkets.com/research/zj7h4f/latin_america ... America Biomedical Sensors Market - Growth, Trends & Forecasts ... Latin America Biomedical Sensors market is estimated at $0.65 ... the period 2014-2020 The near future will ... formulation of each individual. These sensors can be set ...
Breaking Biology News(10 mins):Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 2Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 3FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2Latin America Biomedical Sensors Market Report 2015-2020 2
... The U.S. Food & Drug Administration (FDA) has granted Investigational ... clinical trial evaluating Alpha-1 Antitrypsin (AAT) in type 1 diabetics, ... University of the Negev. This is the first time ... AAT is an FDA-approved off-patent drug currently used to treat ...
... The Netherlands believe they are on the verge of ... able to detect accurately chromosomal abnormalities in the developing ... this is through amniocentesis or chorionic villus sampling, both ... triggering a miscarriage. Dr Suzanna Frints, a clinical ...
... wildfires and influxes of pollutants create disturbances that ... Ecologists had believed that at times like these, ... struggle to survive. But a new laboratory ... of acoustic disturbance now challenges that assumption ...
Cached Biology News:FDA approves trial for type 1 diabetes treatment by Ben-Gurion U. and U. Colorado 2Cheap, simple, noninvasive blood test may replace invasive diagnostic techniques in early pregnancy 2Cheap, simple, noninvasive blood test may replace invasive diagnostic techniques in early pregnancy 3Study challenges long-held assumption about competition in disturbed ecosystems 2Study challenges long-held assumption about competition in disturbed ecosystems 3Study challenges long-held assumption about competition in disturbed ecosystems 4
(Date:7/28/2015)... July 28, 2015 CSL Behring ... has accepted for review the company,s Biologics License Application ... (rVIII-SingleChain) for the treatment of hemophilia A. In the ... Hemophilia A is a congenital ... nearly all affected patients are male. People with hemophilia ...
(Date:7/28/2015)... ZIONA, Israel , ... Ltd. (TASE:CLPT; OTC:CQPTY), a regenerative medicine company utilizing ... products, today announced that Shomrat Shurtz has been ... 20, 2015.      (Photo: http://photos.prnewswire.com/prnh/20150728/246955 ... over 25 years of experience in marketing, regulatory ...
(Date:7/27/2015)... Tenn. , July 27, 2015  Capella ... care services and one of the largest for-profit ... its parent company and sole stockholder, Capella Holdings, ... Properties Trust, Inc. ("MPT") (NYSE: MPW ) ... The transaction is expected to be finalized during ...
(Date:7/27/2015)... ... 27, 2015 , ... Production of high tenacity filament yarn of viscose rayon ... EU. For instance, it surpassed the EUR 106 million mark (in value terms) in ... is a major producer, while Italy is a key consumer. , The high ...
Breaking Biology Technology:U.S. FDA Accepts for Review CSL Behring's Biologics License Application for Its Novel rVIII-SingleChain Therapy for Patients with Hemophilia A 2U.S. FDA Accepts for Review CSL Behring's Biologics License Application for Its Novel rVIII-SingleChain Therapy for Patients with Hemophilia A 3CollPlant Names Shomrat Shurtz Senior Director of Business Development 2Capella Healthcare Announces Agreement With Medical Properties Trust, Inc. 2Capella Healthcare Announces Agreement With Medical Properties Trust, Inc. 3Capella Healthcare Announces Agreement With Medical Properties Trust, Inc. 4Capella Healthcare Announces Agreement With Medical Properties Trust, Inc. 5High Tenacity Filament Yarn of Viscose Rayon Consumption to Grow Swiftly in the EU, Forecasts BAC Reports in New Study Available at MarketPublishers.com 2
... A new Oak Ridge National Laboratory initiative could ... and also lead to more information about climate change. ... will be implemented in Gulfport, Miss., Memphis, and Charleston, ... for, respond to and quickly recover from natural and ...
... combining two materials to make a composite material with ... a mainstay of the marine industry for decades and ... carbon nanotubes (CNT) are getting in on the act ... for polymers in an ideal manner. , Researchers ...
... Calif., Nov. 21 Accuray,Incorporated (Nasdaq: ARAY ), ... that its president and chief executive officer, Euan S.,Thomson, ... Piper,Jaffray,s Health Care Conference at the Pierre Hotel in ... p.m. EST (9:30 a.m. PST)., A live webcast ...
Cached Biology Technology:ORNL 'resilience' plan to help Tennessee, Mississippi and South Carolina communities beat disaster 2Accuray Incorporated's CEO to Speak at Piper Jaffray 19th Annual Health Care Conference 2Accuray Incorporated's CEO to Speak at Piper Jaffray 19th Annual Health Care Conference 3
... with a variety of motion options - ... one unit. Shake, rock, roll and rotate ... for hybridization and blotting procedures requiring different ... upper chamber uses a roller action to ...
... Concentrator, the SPD series takes the 'Classic' ... twist., The SPD121P SpeedVac comes equipped with ... runs; preventing samples from freezing; and allowing ... end-users preset level., Standard features on the ...
... are designed to create the ideal environment for ... to 99.9C) , Variable speed control (10 ... whether it be for washing or hybridizing ... temperature inside the chamber, ,is situated above a ...
... Express is the latest edition to the ... has an extra large diameter exhaust port ... display panel allows precise setting and control ... for handling large quantities and samples ...
Biology Products: