Navigation Links
Researchers find a better way to culture central nervous cells
Date:1/29/2013

PROVIDENCE, R.I. [Brown University] A protein associated with neuron damage in people with Alzheimer's disease is surprisingly useful in promoting neuron growth in the lab, according to a new study by engineering researchers at Brown University. The findings, in press at the journal Biomaterials, suggest a better method of growing neurons outside the body that might then be implanted to treat people with neurodegenerative diseases.

The research compared the effects of two proteins that can be used as an artificial scaffold for growing neurons (nerve cells) from the central nervous system. The study found that central nervous system neurons from rats cultured in apolipoprotein E-4 (apoE4) grew better than neurons cultured in laminin, which had been considered the gold standard for growing mammalian neurons in the lab.

"Most scientists assumed that laminin was the best protein for growing CNS (central nervous system)," said Kwang-Min Kim, a biomedical engineering graduate student at Brown University and lead author of the study, "but we demonstrated that apoE4 has substantially better performance for mammalian CNS neurons."

Kim performed the research under the direction of Tayhas Palmore, professor of engineering and medical science and Kim's Ph.D. adviser. Also involved in the project was Janice Vicenty, an undergraduate from the University of Puerto Rico, who was working in the Palmore lab as a summer research fellow through the Leadership Alliance.

The results are surprising partly because of the association of apoE4 with Alzheimer's. Apolipoproteins are responsible for distributing and depositing cholesterols and other lipids in the brain. They come in three varieties: apoE2, apoE3 and apoE4. People with the gene that produces apoE4 are at higher risk for amyloid plaques and neurofibrillary tangles, the hallmarks of Alzheimer's. But exactly how the protein itself contributes to Alzheimer's is not known.


'/>"/>

Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers find a better way to culture central nervous cells
(Date:4/20/2015)... Huntington Memorial Hospital is the first facility ... miniaturized, wireless monitoring sensor to manage heart failure (HF). ... FDA-approved heart failure monitoring device that has been proven ... to manage heart failure. The CardioMEMS HF ... pulmonary artery (PA) during a non-surgical procedure to directly ...
(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
(Date:4/14/2015)... OXFORD, Conn. , April 14, 2015 ... "Company"), a biometric authentication company focused on the growing ... has been nominated for the 2015 New York Design ... The Design100, New York City Design Awards are ... are based on over 2,500 ratings from the marketplace, ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... Amsterdam, 2 November, 2010 - An investigation conducted in the ... Relevance to Humans, Animals and Ecosystems, demonstrates for the first ... is widespread. In the course of the Summer ... was sampled by mothers who had given birth at the ...
... School meal programs play a significant role in ... comprehensive school nutrition services that improve children,s nutritional ... updated joint position paper from the Society for ... the School Nutrition Association (SNA). The updated ...
... NEW YORK, Nov. 2, 2010 The Online Publishers Association ... Effectiveness of the OPA Ad Unit," that found that 90 ... 10 seconds of being on a webpage and users who ... were as emotionally engaged with the advertising as with the ...
Cached Biology News:Exposure of humans to cosmetic UV filters is widespread 2Exposure of humans to cosmetic UV filters is widespread 3Comprehensive nutrition services vital to children's health 2Online Publishers Association Unveils Biometric and Eye Tracking Research to Assess the Effectiveness of New OPA Ad Units 2Online Publishers Association Unveils Biometric and Eye Tracking Research to Assess the Effectiveness of New OPA Ad Units 3
(Date:4/23/2015)... April 23, 2015  Metanome, Inc., an industry ... company has changed its name to Diversigen, Inc.  ... as the single commercial source for the myriad ... on the diverse opportunities of the microbiome.  From ... accepts – including those that are difficult to ...
(Date:4/23/2015)... /PRNewswire/ - Crystal Research Associates, LLC announced today that ... (EIO) on Aeterna Zentaris Inc. (NASDAQ: AEZS ) (TSX: ... Research Associates, website at www.crystalra.com ... www.aezsinc.com . Aeterna Zentaris ("Aeterna" or "the ... oncology, endocrinology, and women,s health. With a focus on ...
(Date:4/23/2015)... SAN FRANCISCO, CA (PRWEB) April 23, 2015 ... drug delivery, today announced that the United States Patent ... on the Company’s NANOPOR™ technology. US ... and covers Delpor’s microfabricated drug delivery device ... uses Delpor’s proprietary NANOPOR™ technology for the sustained (zero-order) ...
(Date:4/22/2015)... , April 22, 2015  Sangamo BioSciences, Inc. (NASDAQ: ... financial results and accomplishments. For the first ... net loss of $5.3 million, or $0.08 per share, ... $0.12 per share, for the same period in 2014. ... cash equivalents, marketable securities and interest receivable of $226.1 ...
Breaking Biology Technology:Metanome Announces Corporate Name Change to Diversigen 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 3Delpor, Inc. Announces the Issuance of 2 New US Patents Based on its Nanopore Technology which Enables the Sustained Release of Drugs from a Small Implant Device 2Delpor, Inc. Announces the Issuance of 2 New US Patents Based on its Nanopore Technology which Enables the Sustained Release of Drugs from a Small Implant Device 3Sangamo BioSciences Reports First Quarter 2015 Financial Results 2Sangamo BioSciences Reports First Quarter 2015 Financial Results 3Sangamo BioSciences Reports First Quarter 2015 Financial Results 4Sangamo BioSciences Reports First Quarter 2015 Financial Results 5Sangamo BioSciences Reports First Quarter 2015 Financial Results 6Sangamo BioSciences Reports First Quarter 2015 Financial Results 7Sangamo BioSciences Reports First Quarter 2015 Financial Results 8
... ... Addressing Dynamic Needs of Growing World , ... Wilmington, DE (Vocus) July 9, 2010 -- The world’s population ... than 12 years -- with more than 9 billion people expected on earth before ...
... ... be present at the Process Expo 2010 in Chicago from July 18 ... designing and manufacturing of industrial wastewater treatment systems for the food processing ... technology and that FRC is a major well-known and respected DAF (Dissolved ...
... from microelectronics to power lines because of their ballistic ... those electrons in their tracks? Rice physicist Junichiro ... effect -- the interaction between electrically charged particles and ... nanotubes. While doing so, they came to the ...
Cached Biology Technology:United Nations' World Population Day Calls Attention to Key Global Issues 2United Nations' World Population Day Calls Attention to Key Global Issues 3United Nations' World Population Day Calls Attention to Key Global Issues 4United Nations' World Population Day Calls Attention to Key Global Issues 5FRC Systems International State-of-the-art Industrial Wastewater Treatment Systems 2FRC Systems International State-of-the-art Industrial Wastewater Treatment Systems 3Magnets trump metallics 2
... This CLS number is a new ... Cornings product number. If showing no ... old Sigma-Aldrich number (Z71,405-4) or contact ... diam. 60 mm volume diam. ...
... sets of glass plates, bar clamp, and ... features of these units are:, safety interlock ... reservoirs , upper and lower reservoirs have ... safe disposal of buffer solutions , leveling ...
... stain. Reproducible color staining. ... reversers needed. Stains proteins, ... Linear protein-to-stain color intensity. ... per tray. Packaged as ...
Rabbit polyclonal to Quinaldic Acid ( Abpromise for all tested applications). Antigen: Synthetic peptide Quinaldic Acid conjugated to a protein carrier....
Biology Products: