Navigation Links
Researchers find 2 more genetic risk factors for Alzheimer's disease
Date:9/6/2009

St. Louis, Sept. 6, 2009 An international team of scientists has identified two more genetic risk factors for Alzheimer's disease. The findings are reported in the online edition of the journal Nature Genetics.

The group, led by investigators from the School of Medicine at Cardiff in the United Kingdom and including scientists from Washington University School of Medicine in St. Louis, completed the largest genome-wide association study ever involving patients with Alzheimer's disease. The study pooled DNA samples from more than 19,000 older European and U.S. residents. Seven thousand had Alzheimer's disease, and the others had no clinical symptoms of the disorder.

Prior to this study, only four genes had been definitively associated with Alzheimer's disease. Three genetic mutations have been identified as causes of rare, inherited forms of early-onset Alzheimer's. The fourth gene, APOE4, is the only one previously linked to the more common late-onset form of the disease.

By looking at more than 600,000 common DNA markers, researchers on the current study were able to identify two new genes that appeared to be involved in elevated risk for Alzheimer's and confirmed the importance of APOE4.

"There's good evidence that these new genes may be novel risk factors, the first discovered since APOE in 1993," says Washington University researcher and co-author Alison M. Goate, D.Phil. "So it's a very important observation because this study is the first to provide such significant evidence of novel genetic risk factors for the most common form of Alzheimer's disease."

Goate, who in 1991 led a team in England that identified the first early-onset Alzheimer's mutation in the APP gene on chromosome 21, is now the Samuel and Mae S. Ludwig Professor of Genetics in Psychiatry and professor of neurology at Washington University. She says the new genes identified in this study are APOJ, also called clustrin on chromosome 8, and PICALM on chro
'/>"/>

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers restore missing protein in rare genetic brain disorder
2. Mayo Clinic researchers find that protein believed to protect against cancer has a Mr. Hyde side
3. Species diversity helps ASU researchers refine analyses of human gene mutations
4. UT Southwestern researchers examine mechanisms that help cancer cells proliferate
5. Marine biomedicine researchers decode structure of promising sea compound
6. Researchers report gene associated with language, speech and reading disorders
7. Bats use love songs during mating, researchers say
8. Idaho researchers win grant to explore DNA frontier
9. UCSF researchers identify 2 key pathways in adaptive response
10. Disrupting a destructive duo: U of T Mississauga researchers inhibit cancer proteins
11. Researchers boost production of biofuel that could replace gasoline
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... , April 20, 2015 ...   Glenbeigh Records Management (GRM), Ireland,s ... with Dubai Islamic Bank. Having built up an impressive track ... now a leading player within the records management sector in ... expects to double is GCC staffbase and employ a further ...
(Date:4/13/2015)... YORK , April 13, 2015 ... by TechSci Research, "Global Biometrics Market Forecast & Opportunities, ... register a CAGR of around 14% till 2020. ... governments for large scale implementation and review of ... and launch of new products with greater efficiency, ...
(Date:4/8/2015)...  Infinisource, a leading provider of SaaS-based Human Capital ... leading supplier of biometric identification and security solutions, ... advanced biometrically-enabled time clock, the companies announced today. ... setting a bold, new standard for the collection ... and mid-size employer. When connected to the iSolved ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... global leader in forming a proactive response to climate change, ... to the challenges and opportunities the changing climate presents. The ... City Panel on Climate Change (NPCC) and published in the ... outline the measures the city will take to proactively respond ...
... Mass. Since the 1990s, a green fluorescent protein known ... a Pacific Northwest jellyfish, GFP allows scientists to visualize proteins ... their business. Two years ago, biologists who discovered and developed ... for their work. However, using GFP as a fluorescent ...
... May 2010 Red blood cells, the delivery men that ... lives. To keep enough of them in circulation, the human ... even more in response to challenges like severe blood ... of Experimental Medicine , scientists at the European Molecular Biology ...
Cached Biology News:How New York City is preparing for climate change 2How New York City is preparing for climate change 3MIT chemists design new way to fluorescently label proteins 2Making enough red blood cells 2
(Date:4/17/2015)... , April 17, 2015  Centrillion Technologies, ... SBIR grant from the National Human Genome ... of Health (NIH). The grant will help ... the development of breakthrough genomic technologies, including ... fabricated substrates. Centrillion has been developing this ...
(Date:4/17/2015)... April 17, 2015 CIO Review ( ... its 20 Most Promising Pharma and Life Science Technology ... MediSpend global compliance software platform for life sciences companies. ... by a panel of experts and members of CIO ... “MMIS’s MediSpend Platform has been on our radar for ...
(Date:4/17/2015)... -- Guggenheim Securities, the investment banking and capital markets division ... William Tanner as a Managing Director and senior ... work at Guggenheim in May 2015 in the firm,s ... "Bill brings a wealth of biotech experience, in both ... acclaimed healthcare team," said Matthew Johnson , Senior ...
(Date:4/17/2015)... April 17, 2015 Global Stem ... GTCbio Stem Cell Summit 2015 April 27 - 29, ... latest developments in all areas of stem cell research ... stem cells and regenerative medicine. , The conference ... as well as translational research in stem cell therapies, ...
Breaking Biology Technology:MMIS Chosen by CIO Review as Top 20 Most Promising Pharma and Life Science Technology Solution Providers 2015 2Guggenheim Securities Hires Biotech Analyst William Tanner in Expansion of Healthcare Coverage 2Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 2Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 3
... Net Loss Per Share, SAN JOSE, Calif., April ... a leading provider of medical devices,for the minimally invasive ... the first quarter ended March 31, 2008., Net ... to $18.9,million compared with $15.6 million for the first ...
... Available Online at DiscoverTesting.com, Test Kit Developed in Response to ... Consumer ... Silver Lake Research unveils,its newest Watersafe product this week, addressing ... Well Water Test Kit tests for ten contaminants with easy-to-use,at-home ...
... DIEGO, April 21 /PRNewswire-FirstCall/ - MIGENIX Inc.,(TSX: MGI, ... infectious,diseases, has appointed Pieter Dorsman to its Board ... of Redpeaks Management, Inc., a,financial consulting firm in ... development, legal structure and overall business,strategies. Prior to ...
Cached Biology Technology:VNUS Medical Technologies Reports First-Quarter 2008 Results: 21% growth in Net Revenues and 51% Growth in Unit Sales 2VNUS Medical Technologies Reports First-Quarter 2008 Results: 21% growth in Net Revenues and 51% Growth in Unit Sales 3VNUS Medical Technologies Reports First-Quarter 2008 Results: 21% growth in Net Revenues and 51% Growth in Unit Sales 4VNUS Medical Technologies Reports First-Quarter 2008 Results: 21% growth in Net Revenues and 51% Growth in Unit Sales 5VNUS Medical Technologies Reports First-Quarter 2008 Results: 21% growth in Net Revenues and 51% Growth in Unit Sales 6VNUS Medical Technologies Reports First-Quarter 2008 Results: 21% growth in Net Revenues and 51% Growth in Unit Sales 7Silver Lake Research Unveils Watersafe(R) Well Water Test Kit 2MIGENIX Appoints Pieter Dorsman to Board of Directors 2
Active GST Protein...
Cyno macaque plasma and serum - various quantities available...
adult...
Natural Mouse Laminin is purified from the Engelbreth-Holm-Swarm (EHS) sarcoma and is provided in Tris-buffered saline....
Biology Products: