Navigation Links
Researchers explain why some wound infections become chronic
Date:12/17/2013

RIVERSIDE, Calif. Chronic wounds affect an estimated 6.5 million Americans at an annual cost of about $25 billion. Further, foot blisters and other diabetic ulcers or sores account for the vast majority of foot and leg amputations in the United States today.

Why does treating chronic wounds cost so much? What complicates chronic wound infections, making healing difficult?

Manuela Martins-Green, a professor of cell biology at the University of California, Riverside, reports that two biological activities are out of control in chronic wound infections. These are reactive oxygen species (ROS), which are chemically reactive molecules formed by the partial reduction of oxygen, and biofilms that are formed by selective invading bacteria.

ROS is the natural byproduct of the normal oxygen metabolism and plays a role in cell signaling and homeostasis. However, excessive ROS can induce chronic inflammation, a key characteristic of wounds that do not heal. The biofilms are bacterial defense mechanisms. Together they create a toxic environment that can resist efforts to heal and close a chronic wound.

"By decreasing ROS levels within a chronic wound in a diabetic mouse model, my lab was able to normalize conditions and heal the wound," Martins-Green said. "Indeed, we saw significant improvement in healing the wound."

She announced her findings on Dec. 17 in New Orleans, La., at the 53rd annual meeting of the American Society for Cell Biology.

To identify the central role of ROS in maintaining chronic wound infection, Martins-Green's lab inhibited two antioxidan
'/>"/>

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Stanford researchers take a step toward developing a universal flu vaccine
2. Researchers engineer a hybrid 5 times more effective in delivering genetic material into cells
3. New organization brings together top researchers to sequence genomes of invertebrates
4. Bonefish spawning behavior in the Bahamas surprises researchers, should aid conservation
5. Where water is limited, researchers determine how much water is enough
6. Researchers at Penn help develop a dynamic model of tissue failure
7. Leibniz Prizes 2014: DFG honors 11 outstanding researchers
8. Researchers named to National Academy of Inventors
9. Researchers at Penn show optimal framework for heartbeats
10. University researchers observe surprising bonefish spawning behavior in the Bahamas
11. ASU researchers discover chameleons use colorful language to communicate
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers explain why some wound infections become chronic
(Date:9/18/2014)... global cycles of carbon and nitrogen comprise all ... and environmental systems have caused imbalances and perturbations ... gases (GHGs). Increased GHGs result in climate changes ... ecosystems, oceans and the atmosphere. Understanding these feedback ... branch of environmental science during the past three ...
(Date:9/18/2014)... are too stressed they are often grouchy, grumpy, nasty, ... (BMI) at EPFL have just highlighted a fundamental synaptic ... the loss of social skills and cognitive impairment. When ... molecule in the brain. This was revealed by a ... Carmen Sandi,s team went to look for answers in ...
(Date:9/18/2014)... probably the ultimate form of camouflage: you don,t just ... strategy is not as uncommon as you might think. ... USA, explains that the larval life stages of many ... of the anatomy that most creatures cannot make transparent. ... to shield each individual eye unit with an opaque ...
Breaking Biology News(10 mins):Greenhouse gas research enters a new era 2How stress tears us apart 2Transparent larvae hide opaque eyes behind reflections 2
... fibrosis (CF), a chronic disease that clogs the lungs ... a genetic defect in a chloride channel called cystic ... fully understand how or why this defect occurs, a ... (SickKids) in Toronto, Ontario, Canada has found a promising ...
... Oncology (ESMO) has honored three of Europe,s leading medical ... care and research. "The eminent oncologists we ... contributions to the care of patients with cancer," said ... thank them for their unstinting efforts on behalf of ...
... SALT LAKE CITY, Sept. 19, 2011 University ... through walls now are aiming the technology at a ... adults with sleep apnea and babies at risk of ... uses off-the-shelf wireless transceivers similar to those used in ...
Cached Biology News:Unraveling a new regulator of cystic fibrosis 2Oncologists recognized by ESMO for outstanding contributions to cancer research and treatment 2Catching a breath -- wirelessly 2Catching a breath -- wirelessly 3Catching a breath -- wirelessly 4Catching a breath -- wirelessly 5
(Date:9/19/2014)... Barnhardt Manufacturing Company has ... Organic Cotton . The USDA Certified Biobased Product ... ingredients meets or exceeds levels set by USDA. Biobased ... or in significant part of agricultural, forestry, or marine ... cotton to be immediately identified as a USDA certified ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Bipartisan passage ... a bill designed to stimulate development and commercialization of ... being praised by leaders of SPIE, the international ... Revitalizing American Manufacturing and Innovation (RAMI) Act, now moves ... authors have said they are optimistic that it will ...
(Date:9/18/2014)... , Sept. 18, 2014  Health Enhancement Products, Inc. (OTCQB: ... early-stage algae bioactive compounds and metabolic processes, is pleased to ... board of directors. Ms. Nola E. Masterson , a ... joined the board effective September 17, 2014. ... to join our board," states Andrew Dahl , President ...
(Date:9/18/2014)... , Sept. 18, 2014 ... of the "Global N-acetylcysteine Industry Report 2014" ... The Global N-acetylcysteine Industry Report 2014 is a ... of the global N-acetylcysteine industry. The ... including definitions, classifications, applications and industry chain structure. ...
Breaking Biology Technology:Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2Global N-acetylcysteine Industry Report 2014 2
... 2011 StriVectin®, the clinical anti-aging expert, was one ... 2011 Skin Sense Award Tuesday night at The Plaza. ... exceptional achievement in skin health.  The company was recognized ... rooted in 30 years of research into DNA repair ...
... YORK, Oct. 12, 2011 Reportlinker.com announces ... available in its catalogue: ... Annual Subscription ... Twelfth Five-Year Plan of Biotechnology Industry to ...
... officials announced today a five-year agreement with K.S.R. Educational ... training in nanomedicine and nanotechnology. "We are very ... 16 institutions of higher education in Tamil Nadu, India," ... has the same commitment to deliver quality education to ...
Cached Biology Technology:StriVectin® Receives Annual Skin Sense Award 2Industrial Biotechnology China News 1109 - Annual Subscription 2Industrial Biotechnology China News 1109 - Annual Subscription 3MU signs academic agreement with K.S.R. Educational Institutions of India 2
... routine binary separations. Excellent detection is provided ... variable wavelength detector. Ultra-fine control of the ... highly accurate and precise, high pressure dual piston ... may be plotted on a printer or an ...
... Human Raji cells were cultured in RPMI ... at the log phase of growth. In ... forms, cells were fixed in acetone-methanol. The ... adhesive coated slide, with each wells surface specifically ...
Mouse polyclonal antibody to REXO4 - XPMC2 prevents mitotic catastrophe 2 homolog (Xenopus laevis)...
... Plus Microsphere/Microarray Stabilizer is an aqueous solution ... other non-toxic chemicals in a PBS buffer ... This product contains a combination of ... preservative. StabilCoat Plus Stabilizer provides optimum ...
Biology Products: