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Researchers expand efforts to explore functional landscape of the human genome
Date:10/9/2007

ctivities of promoters. Promoters are regions of DNA that serve as binding sites for proteins that guide the initiation of transcription of genes.

The Data Coordination Center for ENCODE will be led by:

  • W. James Kent, Ph.D.; University of California, Santa Cruz; $5 million (four years); The UCSC ENCODE Data Coordination Center. This group will collect, organize, store, manage and provide access to data from ENCODE and related projects.

The principal investigators chosen to receive technology development grants are:

  • Howard Chang, M.D., Ph.D.; Stanford University, Stanford, Calif.; $1.3 million (three years); Structural Motifs in RNA. These researchers will develop high-throughput methods to predict functional motifs in RNA, to map RNA structure and to assign biological functions to RNA motifs.

  • Michael Dorschner, Ph.D.; University of Washington, Seattle; $1.1 million (three years); High-Definition In Vivo Footprinting via Single Molecule Sequencing. This groups goal is to develop an in vivo method that utilizes single molecule sequencing to identify sites of protein-DNA interaction by differential cleavage sensitivity with ultraviolet light, dimethylsulfate and DNase I.

  • John Greally, Ph.D.; Albert Einstein College of Medicine, Bronx, N.Y.; $1.5 million (three years); Massively Parallel Sequencing Technology for the Epigenome. This team will work to develop high-throughput sequencing methods to analyze methylation of cytosine and to map histone modifications.

  • Xiaoman Li, Ph.D.; Indiana University, Indianapolis; $870,000 (three years); Discovery of Cis-Regulatory Modules in the Human Genome. This team will strive to develop computational methods for identifying conserved cis-regulatory modules in non-protein coding regions of the human genome.

  • Marcelo Nobrega, M.D., Ph.D.; University of Chicago; $1.5 million (three years
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Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

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