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Researchers expand efforts to explore functional landscape of the human genome
Date:10/9/2007

t sequencing to determine the methylation status of CpG-rich regions of the human genome. Transcription factors are proteins and enzymes that initiate the transcription of a genes DNA sequence into RNA. Methylation refers to a specific chemical modification of DNA, which can silence or reduce the activity of the affected region of DNA.

  • Michael Snyder, Ph.D.; Yale University, New Haven, Conn., $11.5 million (four years); Production Center for Global Mapping of Regulatory Elements. These researchers will identify transcription factor binding sites in the human genome using chromatin immunoprecipitation, followed by high-throughput sequencing.

  • John Stamatoyannopoulos, M.D.; University of Washington, Seattle; $9.7 million (four years); A Comprehensive Catalog of Human DNase I Hypersensitive Sites. This team will map and functionally classify DNase I hypersensitive sites across major human cell lineages. It will do this using digital DNase I and histone modification mapping by high-throughput sequencing. DNAse I is an enzyme that cleaves DNA at sites where it is exposed by regulatory proteins. DNase I hypersensitive sites mark the location of regulatory elements in the human genome.

The principal investigators chosen to receive the ENCODE pilot-scale grants are:

  • Scott Tenenbaum, Ph.D.; University at Albany-State University of New York; $2.2 million (three years); Comprehensive Identification of ENCODE RNA-based, Cis-regulatory Elements. In this pilot project, researchers will strive to identify sites that are targets for RNA-binding proteins through immunoprecipitation coupled with microarrays and high-throughput sequencing.

  • Zhiping Weng, Ph.D.; Boston University; $1.5 million (three years); Identification of Transcriptional Factor-Binding Sites in Human Promoters. This pilot project will aim to computationally predict transcription factor binding sites that determine the a
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Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

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