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Researchers expand efforts to explore functional landscape of the human genome
Date:10/9/2007

enes and their associated proteins, the ENCODE data indicate the genome is a very complex, interwoven network in which genes are just one of many types of DNA sequences with functional impact.

We learned many valuable lessons from the ENCODE pilot project. Among them was the importance of scientific teamwork, said Elise A. Feingold, Ph.D., program director for ENCODE in NHGRIs Division of Extramural Research. Following the pilots strong example of multi-disciplinary collaboration, we are confident that the scaled-up ENCODE team will succeed in its quest to build a comprehensive catalog of the components of the human genome that are crucial to biological function.

In addition to the research grants to support expansion of the ENCODE project, NHGRI also announced awards today for two pilot-scale projects, the establishment of an ENCODE data coordination center, and six projects to develop novel methods and technologies aimed at helping the ENCODE project achieve its goals.

As was the case for the Human Genome Project and the ENCODE pilot, all of the data generated by the full-scale ENCODE project will be deposited into public databases as soon as they are experimentally verified, said Peter Good. Ph.D., program director for genome informatics in NHGRIs Division of Extramural Research. Free and rapid access to this data will enable researchers around the world to pose new questions and gain new insights into how the human genome functions.

The principal investigators chosen to receive the ENCODE scale-up grants are:

  • Bradley Bernstein, M.D., Ph.D.; Broad Institute of MIT and Harvard, Cambridge, Mass.; $4.8 million (four years); High-Throughput Sequencing of Chromatin Regulatory Elements. Utilizing the technique of chromatin immunoprecipitation followed by high-throughput DNA sequencing, this team will map modifications of histones in various types of human cells. Histones are proteins that play a key role in DNA pac
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Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

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