Navigation Links
Researchers examine developing hearts in chickens to find solutions for human heart abnormalities
Date:1/21/2009

COLUMBIA, Mo. When it is head versus heart, the heart comes first. The heart is the first organ to develop and is critical in supplying blood to the rest of the body. Yet, little is known about the complex processes that regulate the heartbeat. By studying chickens' hearts, a University of Missouri researcher has identified certain proteins within the heart muscle that play an important regulatory role in embryonic heartbeat control. Understanding these components and how they interact will give researchers a better understanding of heart development and abnormalities in humans.

VIDEO: In the early stages of heart development, the heart is a tube that has uniform shape and does not have a clear atrium or ventricle. As development progresses, a single...

Click here for more information.

lign="left">

VIDEO: In the early stages of heart development, the heart is a tube that has uniform shape and does not have a clear atrium or ventricle. As development progresses, a single...

Click here for more information.

In the study, researchers examined embryonic chickens' hearts, which develop morphologically and functionally similarly to humans' hearts, and tested the electrical activity present in the cardiac muscle cells over a period of 24 hours. They found that changes in local proteins have important effects on embryonic heart beat control.

"Electrical activity in the heart appears in very early stages of development," said Luis Polo-Parada, assistant professor in the Department of Medical Pharmacology and Physiology in the MU School of Medicine and investigator in the Dalton Cardiovascular Research Center. "This study determined the role of the heart microenvironment in regulating electrical activity in cardiac cells that are required for normal cardiac function. Understanding exactly how a heart is made and how it begins to function will allow us to significantly improve therapies for a wide range of cardiac anomalies, injuries and diseases such as hypertension, cardiac fibrosis, cardiac hypertrophy and congestive heart failure."

Cardiac function depends on appropriate timing of contraction in various regions of the heart. Fundamental to the control of the heart are the electrical signals that arise within the heart cells that initiate contraction of the heart muscle. The upper chambers of the heart, the atria, must contract before the lower chambers, the ventricles, to obtain a coordinated contraction that will propel the blood throughout the body. While scientists understand the gross actions of the electrical signals that drive cardiac contraction, little is known about changes in the local environment of the embryonic and adult heart cells that influence these contractions.


'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Related biology news :

1. JDRF-funded researchers discover proteins regulating human beta cell replication
2. Researchers to use K-States BSL-3 Lab for $1 million study of fungus threatening wheat crops
3. Researchers identify potential new weapon in battle against HIV infection
4. U-M researchers discover new genes that fuse in cancer
5. Researchers first to see reactive oxygen species in vital enzyme
6. Dartmouth researchers find new protein function
7. Burnham researchers discover on switch for cell death signaling mechanism
8. Salk researchers develop novel glioblastoma mouse model
9. New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics
10. The gold standard: Biodesign Institute researchers use nanoparticles to make 3-D DNA nanotubes
11. Researchers engineer pancreatic cell transplants to evade immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... 2016 The new GEZE SecuLogic ... web-based "all-in-one" system solution for all door components. It ... the door interface with integration authorization management system, and ... The minimal dimensions of the access control and the ... installations offer considerable freedom of design with regard to ...
(Date:4/15/2016)... DUBLIN , April 15, 2016 ... of the,  "Global Gait Biometrics Market 2016-2020,"  report ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait ... CAGR of 13.98% during the period 2016-2020. ... movement angles, which can be used to compute ...
(Date:4/13/2016)...  IMPOWER physicians supporting Medicaid patients in ... standard in telehealth thanks to a new partnership with ... IMPOWER patients can routinely track key health measurements, such ... and, when they opt in, share them with IMPOWER ... local retail location at no cost. By leveraging this ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... YM (Yeast and Mold) microbial test has received AOAC Research Institute approval 061601. ... microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory and ...
(Date:6/23/2016)... FRANCISCO , June 23, 2016   EpiBiome ... has secured $1 million in debt financing from Silicon ... ramp up automation and to advance its drug development ... its new facility. "SVB has been an ... beyond the services a traditional bank would provide," said ...
(Date:6/23/2016)... ... 23, 2016 , ... In a new case report published today in STEM ... who developed lymphedema after being treated for breast cancer benefitted from an injection of ... dealing with this debilitating, frequent side effect of cancer treatment. , Lymphedema ...
(Date:6/23/2016)... , June 23, 2016 ... Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published ... the peer-reviewed journal from touchONCOLOGY, Andrew D ... cost of cancer care is placing an increasing ... of expensive biologic therapies. With the patents on ...
Breaking Biology Technology: