Navigation Links
Researchers examine developing hearts in chickens to find solutions for human heart abnormalities
Date:1/21/2009

COLUMBIA, Mo. When it is head versus heart, the heart comes first. The heart is the first organ to develop and is critical in supplying blood to the rest of the body. Yet, little is known about the complex processes that regulate the heartbeat. By studying chickens' hearts, a University of Missouri researcher has identified certain proteins within the heart muscle that play an important regulatory role in embryonic heartbeat control. Understanding these components and how they interact will give researchers a better understanding of heart development and abnormalities in humans.

VIDEO: In the early stages of heart development, the heart is a tube that has uniform shape and does not have a clear atrium or ventricle. As development progresses, a single...

Click here for more information.

lign="left">

VIDEO: In the early stages of heart development, the heart is a tube that has uniform shape and does not have a clear atrium or ventricle. As development progresses, a single...

Click here for more information.

In the study, researchers examined embryonic chickens' hearts, which develop morphologically and functionally similarly to humans' hearts, and tested the electrical activity present in the cardiac muscle cells over a period of 24 hours. They found that changes in local proteins have important effects on embryonic heart beat control.

"Electrical activity in the heart appears in very early stages of development," said Luis Polo-Parada, assistant professor in the Department of Medical Pharmacology and Physiology in the MU School of Medicine and investigator in the Dalton Cardiovascular Research Center. "This study determined the role of the heart microenvironment in regulating electrical activity in cardiac cells that are required for normal cardiac function. Understanding exactly how a heart is made and how it begins to function will allow us to significantly improve therapies for a wide range of cardiac anomalies, injuries and diseases such as hypertension, cardiac fibrosis, cardiac hypertrophy and congestive heart failure."

Cardiac function depends on appropriate timing of contraction in various regions of the heart. Fundamental to the control of the heart are the electrical signals that arise within the heart cells that initiate contraction of the heart muscle. The upper chambers of the heart, the atria, must contract before the lower chambers, the ventricles, to obtain a coordinated contraction that will propel the blood throughout the body. While scientists understand the gross actions of the electrical signals that drive cardiac contraction, little is known about changes in the local environment of the embryonic and adult heart cells that influence these contractions.


'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Related biology news :

1. JDRF-funded researchers discover proteins regulating human beta cell replication
2. Researchers to use K-States BSL-3 Lab for $1 million study of fungus threatening wheat crops
3. Researchers identify potential new weapon in battle against HIV infection
4. U-M researchers discover new genes that fuse in cancer
5. Researchers first to see reactive oxygen species in vital enzyme
6. Dartmouth researchers find new protein function
7. Burnham researchers discover on switch for cell death signaling mechanism
8. Salk researchers develop novel glioblastoma mouse model
9. New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics
10. The gold standard: Biodesign Institute researchers use nanoparticles to make 3-D DNA nanotubes
11. Researchers engineer pancreatic cell transplants to evade immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2016)... This BCC Research report provides an overview ... Sequencing (RNA Seq) market for the years 2015, 2016 ... reagents, data analysis, and services. Use this ... market such as RNA-Sequencing tools and reagents, RNA-Sequencing data ... each segment and forecast their market growth, future trends ...
(Date:3/8/2016)... 2016   Valencell , the leading innovator ... has secured $11M in Series D financing. The ... venture fund being launched by UAE-based financial services ... investors TDF Ventures and WSJ Joshua Fund. Valencell ... triple-digit growth and accelerate its pioneering innovation in ...
(Date:3/3/2016)... and DE SOTO, Kansas ... U.S.-based Stroke Detection Plus® to offer Oncimmune,s Early ... assessment and early detection of lung cancer ... employers, unions and individuals. --> Early CDT®-Lung ... and individuals. --> Oncimmune, a leader in ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... York, NY (PRWEB) , ... April 28, 2016 ... ... QuickSTAT has made significant investments in recruiting top industry experts, and expanding its ... Platform, which provides industry-leading tools for clients to manage their clinical trial projects. ...
(Date:4/27/2016)... ... 2016 , ... Shimadzu Scientific Instruments (SSI) will be showcasing ... Conference and Expo. Shimadzu’s high-performance instruments enable laboratories to test cannabis products for ... stop by booth 1021 to learn how Shimadzu’s instruments can help improve QA/QC ...
(Date:4/27/2016)... Columbia , April 27, 2016 ... "NanoStruck") (CSE: NSK) (OTCPink: NSKQB) ( Frankfurt ... Anschluss an ihre Pressemitteilung vom 13. August 2015 ... hat, ihre Finanzen um zusätzliche 200.000.000 Einheiten auf ... Kanadische Dollar zu bringen. Davon wurden 157.900.000 Einheiten ...
(Date:4/27/2016)... VIRGINIA (PRWEB) , ... April 27, 2016 , ... ... today that Jon Clark has joined the company as an Expert Consultant. ... responsible for industry collaborations and managing the development of small molecule monographs based ...
Breaking Biology Technology: