Navigation Links
Researchers engineer functioning small intestine in laboratory experiments
Date:7/5/2011

LOS ANGELES (July 5, 2011) Researchers at The Saban Research Institute of Children's Hospital Los Angeles have successfully created a tissue-engineered small intestine in mice that replicates the intestinal structures of natural intestinea necessary first step toward someday applying this regenerative medicine technique to humans.

The study led by Tracy C. Grikscheit, MD "A Multicellular Approach Forms a Significant Amount of Tissue-Engineered Small Intestine in the Mouse" has been published in the July issue of Tissue Engineering Part A, a premier biomedical journal.

"In this paper, we are able to report that we can grow tissue-engineered intestine in a mouse model, which opens the doors of basic biology to understand how to grow this tissue better," said Dr. Grikscheit, who is also an assistant professor of surgery at the Keck School of Medicine of the University of Southern California.

As a pediatric surgeon, Dr. Grikscheit is concerned with finding solutions for some of her more vulnerable patientsnewborns. Infants born prematurely are at increased risk for a gastrointestinal disease called necrotizing enterocolitis (NEC), which occurs when the intestine is injured. The cause is unknown.

Early treatment of NEC is essential to stop the potentially life-threatening leakage of bacteria into the abdomen. Often, the only solution is surgical removal of the small intestine. However, this option leaves the baby dependent on intravenous feeding and at risk for liver damage from subsequent intravenous nutrition. Organ transplants are possible but not a long-term solution, with only a 50 percent chance the grafted intestine will last past the child's 5th birthday.

Dr. Grikscheit, a member of The Saban Research Institute's Developmental Biology and Regenerative Medicine program, envisions a better solution. "The small intestine is an exquisitely regenerative organ. The cells are constantly being lost and replac
'/>"/>

Contact: Ellin Kavanagh
ekavanagh@chla.usc.edu
323-361-8505
Children's Hospital Los Angeles
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Researchers can predict accurately the outcome of pregnancies threatening to miscarry
2. Researchers decipher protein structure of key molecule in DNA transcription system
3. Geneticist receives Excellence in Science Award from coalition of biomedical researchers
4. Researchers predict locations for deer vs. car collisions
5. UBC researchers invent new drug delivery device to treat diabetes-related vision loss
6. U of M researchers contribute to global plant database, expanding ecosystems research
7. Mount Sinai researchers develop new gene therapy for heart failure
8. UCI, French researchers find master switch for adult epilepsy
9. CU researchers develop new software to advance brain image research
10. Duke researchers learn how lung fibrosis begins and could be treated
11. U of T researchers crack full-spectrum solar challenge
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers engineer functioning small intestine in laboratory experiments 
(Date:9/30/2014)... it comes to using marijuana, new research, involving mice ... Journal of Leukocyte Biology , suggests ... that you should. That,s because a team of Italian ... do serious long-term damage to the immune system. This ... diseases, such as multiple sclerosis, inflammatory bowel disease and ...
(Date:9/30/2014)... with IVF? Here,s some hope: A new research report ... FASEB Journal , explains how scientists developed a ... which induced embryo development in human and mouse eggs ... the sperm cell during fertilization. , "We believe that ... shift in our understanding of human fertilization by providing ...
(Date:9/30/2014)... perilous threats in today,s ocean. From overfishing and ... coral ecosystems are disappearing at unprecedented rates around ... corals surrounding the island of Moorea in French ... environment: coral guard-crabs. New research from the National ... Seabird McKeon and the museum,s predoctoral fellow Jenna ...
Breaking Biology News(10 mins):Adolescent exposure to thc may cause immune systems to go up in smoke 2Synthetic sperm protein raises the chance for successful in vitro fertilization 2Smithsonian scientists discover coral's best defender against an army of sea stars 2
... Scientists have recorded and identified one of the most ... ice as it melts into the sea. The noise, caused ... could provide clues to the rate of glacier melt and ... Geophysicist Erin Pettit, a researcher at the University of Alaska, ...
... international team of scientists, including researchers at Columbia University Medical ... malaria parasites require for survival at each stage of infection ... approach to combating malaria, one of the world,s deadliest diseases. ... the journal Nature . "Perhaps the most ...
... the Graduate School of Excellence "Materials Science in Mainz" ... Tonhauser. Anna Maria Hofmann received the prize for work ... honored for her thesis on functional polyethylene glycols. The ... prize money of EUR 2,000 and has been given ...
Cached Biology News:Glaciers sizzle as they disappear into warmer water 2Study finds new vulnerability in malaria parasite 2MAINZ award for Anna Maria Hofmann and Christine Tonhauser 2
(Date:9/30/2014)... Rainbow Scientific, Inc. (RSI), a ... opened an online store to add customer convenience ... developed and manufactured by Biological Industries, Inc. , ... Industries’ Nutristem® serum-free, xeno-free reagents for human mesenchymal ... (hESC) culture. , The online store also ...
(Date:9/30/2014)... Cambridge MA and Pittsburgh PA (PRWEB) September 30, ... of Clinical Research Nurses ( IACRN), a ... Alliance for Clinical Research Excellence and Safety ... announced the signing of a strategic alliance agreement, ... , IACRN’s vision is to enhance clinical research ...
(Date:9/29/2014)... , Sept. 29, 2014 Research ... "Oligonucleotide Synthesis Market by Product & Services, End-User , ... their offering. The global oligonucleotide synthesis ... from $1,070.7 million in 2014, growing at a CAGR ... synthesis market is categorized on the basis of products ...
(Date:9/29/2014)... 2014 According to ... Product (Modifying Enzymes, DNA Polymerase, Acetylase, Methyltransferase, ... Reagents), by Research Area (Developmental Biology, Oncology), ... 2019", published by MarketsandMarkets, provides a detailed ... current market trends, and strategies impacting the ...
Breaking Biology Technology:Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2IACRN and ACRES to Support Clinical Research Nurses 2IACRN and ACRES to Support Clinical Research Nurses 3Oligonucleotide Synthesis (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) Market - Global Forecast to 2019 2Oligonucleotide Synthesis (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) Market - Global Forecast to 2019 3Epigenetics Market Worth $783.17 Million by 2019 2Epigenetics Market Worth $783.17 Million by 2019 3Epigenetics Market Worth $783.17 Million by 2019 4
... doubled Hectorol sales , Middleton, Wis. Bone ... the work of University of Wisconsin-Madison professor Hector DeLuca, reported ... said its sales of the drug Hectorol were $19.6 million, ... million, despite large theft , Neenah, Wis. ...
... Actor Michael J. Fox plans to visit the Waisman ... Jim Doyle and Fox will hold a media event ... for biotechnology research in Wisconsin. , ,In November, Doyle ... biotechnology and stem cell research, including a collective $750 ...
... wrote about the importance of transparency, which I described ... and maybe even personal perspectives" so that "intelligent consumers ... and write." , ,This transparency puts content in context, ... where the rules of reportorial journalism, more often than ...
Cached Biology Technology:Michael J. Fox coming to UW Waisman Center 2Corporations and blogging 2Corporations and blogging 3
Mouse monoclonal antibody raised against a partial recombinant ST3GAL2. NCBI Entrez Gene ID = ST3GAL2...
... Extraction Kit is manufactured for DNA purification ... byexposure to UV light. The Purification of ... used for DNA-cloning work. The conventional method ... exposure of UV light damages DNA and ...
CleanBox DNA workstation with two 254nm UV lambs & 12-hr timer, 90cm (36-inch)width, single door, 115V (w/crating)...
Mouse monoclonal antibody raised against a full length recombinant PPIL2. NCBI Entrez Gene ID = PPIL2...
Biology Products: