Navigation Links
Researchers embark on work to control the prion epidemic affecting deer in the USA
Date:5/19/2010

ics Unit of the CIC bioGUNE, which started its work earlier this year in 2010 at the Bizkaia Technology Park under the direction of Joaqun Castilla, a researcher hired by the IkerBasque Agency, with the main objective of furthering knowledge of transmissible spongiform encephalopathies (TSEs).

The role of prion strains

The findings of the CIC bioGUNE researchers, who were part of an international team coordinated by the University of Kentucky, studied the role of the various properties of the prion strains in the transmission and spreading of a prion disease in depth, something which until now was unknown.

For this study, transgenic mice susceptible to prion disease in cervids were designed and generated. For the first time, these animals helped identify two biologically distinguishable strains of CWD prions, which has led to the conclusion that both prion strains are interrelated. Whilst the transgenic mice, designed to replicate Canadian deer prions, showed a stable propagation of each one of the prion strains, the transgenic mice designed to replicate prions from mule deer propagated an unstable mixture of CWD strains, preventing their separation through their biochemical properties.

The significance of this study is due to the fact that it is the first time that a single difference in the primary sequence of amino-acids of the protein responsible for prion diseases (Canadian deer versus mule deer) is shown, allowing the selection of prion strains. This discovery shows new data on the possibility of controlling the stability of some prion strains by means of modification of the primary structure of the protein responsible. For the first time, the study also shows the existence of at least two types of CWD strains with clearly distinct pathogenic behaviours.

In this last decade much has been achieved in the understanding of prions. In this regard, the epidemic of the bovine spongiform disease in Europe ("mad cow" dis
'/>"/>

Contact: Oihane Lakar
o.lakar@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... museums of the world are billions of animal and ... mushrooms and grasses, all stacked, stored and preserved in ... collections could be critical to understanding how the Earth,s ... human footprint if only the information were easily ... with the help of a team from the University ...
(Date:5/23/2013)... reveal the interplay of brain chemicals which help us ... and BBSRC. , By changing the way neurons ... While these changes can affect the strength of a ... that response. , Lead author Alex Thiele, ... others, you can make yourself better heard by speaking ...
(Date:5/22/2013)... 22, 2013 U.S. Forest Service scientists are part ... funding from the TKF Foundation, will examine how collaborative ... individuals recover from tragedy. , The TKF Foundation announced ... projects selected for grant funding. In addition to research ... in recovery and resiliency, the 3-year, $585,000 grant will ...
Breaking Biology News(10 mins):CU-Boulder helps tap crowds to digitize museum records of bugs and plants 2CU-Boulder helps tap crowds to digitize museum records of bugs and plants 3CU-Boulder helps tap crowds to digitize museum records of bugs and plants 4'Landscapes of Resilience' to study how people use nature as a source of recovery 2
... from oil palm plantations has calculated a more than ... than previously thought and warned that the demand ... The study from the University of Leicester was conducted ... think tank that wished to assess the greenhouse gas ...
... the number of burgers served has eclipsed the billion ... Genome Institute (JGI) will now serve up trillions of ... to feed the data-hungry worldwide research community. ... researchers to submit proposals for projects that advance capabilities ...
... share the most up-to-date news on the determinants of human ... current topics at The Gerontological Society of America ,s ... the largest interdisciplinary conference in the field of aging ... GSA extends complimentary registration to working representatives of the ...
Cached Biology News:New study suggests EU biofuels are as carbon intensive as petrol 2New study suggests EU biofuels are as carbon intensive as petrol 3New study suggests EU biofuels are as carbon intensive as petrol 4Trillions served: Massive, complex projects for DOE JGI 2012 Community Sequencing Program 2Trillions served: Massive, complex projects for DOE JGI 2012 Community Sequencing Program 3Trillions served: Massive, complex projects for DOE JGI 2012 Community Sequencing Program 4Trillions served: Massive, complex projects for DOE JGI 2012 Community Sequencing Program 5Register now! Boston meeting will showcase latest aging discoveries 2Register now! Boston meeting will showcase latest aging discoveries 3
(Date:5/24/2013)... Quincy Bioscience, a leading research company ... proteins to support healthy living, is pleased to ... apoaequorin in Food and Chemical Toxicology ... Industrial Biological Research Association. , The objective ... effects, if any, of apoaequorin, in rats following ...
(Date:5/23/2013)...  BioScrip, Inc. (NASDAQ: BIOS ) today ... 2013 Global Healthcare Conference to be held June 3-6, ... Richard Smith , President and Chief ... Chief Financial Officer, will present on Monday, June 3, ... About BioScrip BioScrip, Inc. provides comprehensive infusion ...
(Date:5/23/2013)... 2013 PuraMed BioScience ® , Inc., ... over-the-counter (OTC) medicinal and healthcare products, announced that ... company based on low market capitalization valuation. ... Natural Product to Treat Migraine Headaches , ... Competitor , Currently Available Nationwide at Walgreen,s ...
(Date:5/23/2013)... May 23, 2013 VG Energy, an ... with DAK Renewable Research to conduct field trials ... VG Energy is a majority owned subsidiary of ... VG Energy,s exclusively licensed compound LipidMax selectively ... yield in plants, possessing a wide variety of ...
Breaking Biology Technology:Safety Assessment Study of Apoaequorin Published in Food and Chemical Toxicology 2PuraMed BioScience (PMBS) Issued Alert Based on Market Cap of $721,756 2PuraMed BioScience (PMBS) Issued Alert Based on Market Cap of $721,756 3VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials 2VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials 3
... - OncoGenex Technologies Inc. and Isis,Pharmaceuticals, Inc. (NASDAQ: ... amended their agreement and OncoGenex has elected to ... amended agreement,OncoGenex is solely responsible for all future ... Isis will no longer be,responsible for funding 35% ...
... XI,AN, China, July 3 /Xinhua-PRNewswire-FirstCall/ -- Huifeng,Bio-Pharmaceutical ... leading,developer and producer of plant extracts and ... and food production in China,announced today that ... via,Standard & Poor,s Market Access Program, an ...
... July 3 Nabriva Therapeutics, a,specialist in antibiotics ... as Chief Executive Officer of the Company., ... years of industry,experience serving most recently as Vice ... oncology business unit at Novartis. In this,position he ...
Cached Biology Technology:OncoGenex increases economic interest in lead cancer drug OGX-011 2OncoGenex increases economic interest in lead cancer drug OGX-011 3OncoGenex increases economic interest in lead cancer drug OGX-011 4Huifeng Bio-Pharmaceutical (HFGB) Information to Be Available Through Standard & Poor's Market Access Program 2Nabriva Therapeutics Announces Appointment of New CEO 2
... Mouse Antibody to Human Cytokeratin TYPE ... Basic (Type II) keratins. Including epidermal cell ... at 58kD, 65kD and 67kD. Broad keratin ... oesophagus and cornea. Immunogen: ...
BD BioCoat Fibronectin 150 mm Culture Dishes...
... a new product number, created to easily ... availability yet, please order under the old ... for assistance. ID clarifier: tissue-culture ... 500 cm 2 D H ...
... maximum packaging efficiencies of cDNA and genomic DNA ... a test insert with Novagen's l vector arms, ... 10^8 pfu/g ligated l control DNA) are typically ... use; simply add up to 5 g of ...
Biology Products: