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Researchers discover weak link in Alzheimer's drug candidates
Date:4/1/2010

ve we are providing the most direct mechanism of Alzheimer's disease and Down Syndrome pathology. Through our research we have provided a structure and mechanism (an ion channel) that can account for the pathology. The strategy to control the activity of this structure the opening and closing of the channel should be targeted for an effective treatment."

Lal and his colleagues are now working on a 3D structural model of the ion channel using their data to identify the domains (or sites) of the channel for designing effective therapeutics. Lal said the use of advanced nanotechnology and biology combined with a multi disciplinary approach, aided in the researchers' breakthrough discovery.

"Without advances in technology and a multi disciplinary approach this kind of complex research would not move forward," said Lal, a trained physicist and neurobiologist who joined the UCSD faculty in January 2010 from the University of Chicago. ""My goal is to provide practical solutions for effective human health management using advances in nanoscience and technology with a multidisciplinary and multi-scale (nano-to-translational) integrated approach," he added.


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Contact: Andrea Siedsma
asiedsma@soe.ucsd.edu
858-822-0899
University of California - San Diego
Source:Eurekalert  

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