Navigation Links
Researchers discover weak link in Alzheimer's drug candidates
Date:4/1/2010

Some current therapies being investigated for Alzheimer's disease may cause further neural degeneration and cell death, according to a breakthrough discovery by UC San Diego researchers. By combining three dimensional computer simulations with high resolution atomic force microscopy membrane protein and cell imaging, electrical recording and various cellular assays, UCSD nano-biophysicist Ratnesh Lal and his colleagues investigated the structure and function of truncated peptides, known as nonamyloidgenic peptides, formed by some Alzheimer's drug candidates. The researchers found that the nonamyloidgenic peptides formed active ion channels that caused the cells to take in very high levels of calcium ions, which damaged synaptic efficiency and eventually killed neurons, neurons that are linked to memory loss in human brain.

As a result of their current findings and related previous work, Lal and his colleagues believe that aggregate-forming amyloidogenic peptides promote neurological diseases by forming holes or channels in cell membranes, disturbing ionic homeostasis by allowing unwanted ion flow in-and-out of cells, and most importantly allowing toxic amounts of calcium ions into neural cells. Truncated, shorter non-amyloidogenic peptide fragments that also form ion channels and alter neuronal viability, are assumed by biomedical researchers to be non-toxic and are currently targeted to treat Alzheimer's disease patients. Details of their research were recently published in a paper entitled "Truncated β-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome" in the Proceedings of the National Academy of Sciences.

"There are several drugs to treat Alzheimer's in Trials I and II, but we don't believe that they will be adopted for clinical usage," said Lal, a joint professor in the UCSD Jacobs School of Engineering's Department of Mechanical and Aerospace Engineering and Bioengineering. We belie
'/>"/>

Contact: Andrea Siedsma
asiedsma@soe.ucsd.edu
858-822-0899
University of California - San Diego
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers discover weak link in Alzheimer's drug candidates
(Date:4/23/2014)... and German . ... the difference between sexes depends on one single element of the ... the two sexual chromosomes are X and Y, whereas women have ... the morphological and physiological differences between males and females. , But ... ago, the X and Y were identical, until the Y started ...
(Date:4/23/2014)... is available in French and Spanish ... 23 April 2014Today, the CEC released its Conservation Assessment ... Approach to Conservation, which identifies 29 priority conservation areas ... includes 11 different protected areas in the states of ... diverse arid and semi-arid habitats inhabited by rare and ...
(Date:4/23/2014)... People who have had a stroke, often suffer motor ... a study conducted in Taiwan, that will be published ... but is currently freely available on-line as an unedited ... when one group of stroke victims had their own ... brain and a similar group did not, those who ...
Breaking Biology News(10 mins):Male or female? 2Male or female? 3Conservation priorities released for several protected areas along US-Mexico border 2Conservation priorities released for several protected areas along US-Mexico border 3Autologous stem cell therapy improves motor function in chronic stroke victims 2
... YORK (Feb. 28, 2013) The Democratic Republic of ... Okapi Faunal Reserve (OFR), has declined by 37 percent in ... according to wildlife surveys by WCS and DRC officials. ... DRC continues unabated, the species could be nearly extinguished from ...
... source of great controversyparticularly in Europebut acts of vandalism ... the health and ecological impacts of those crops hard ... for use in GM crop studies could serve as ... crop biotechnology, according to an article published in ...
... 2,778 bees while retracing the muddy steps of a scientist ... than a century ago. Occasionally stung, but considering herself ... guided her field work, the Montana State University ecologist and ... ." "It,s exciting," Burkle said as the Feb. 28 ...
Cached Biology News:Elephants are vanishing from DRC's best-run reserve 2Elephants are vanishing from DRC's best-run reserve 3Elephants are vanishing from DRC's best-run reserve 4Fighting GM crop vandalism with a government-protected research site 2Old records, new bees result in 'Science' paper for MSU ecologist 2Old records, new bees result in 'Science' paper for MSU ecologist 3
(Date:1/15/2014)... VA (PRWEB) January 15, 2014 Two ... have continued their sponsorship of an annual competition for ... in, and access to, innovative STEM study. The competition ... TEAMS: Tests of Engineering Aptitude, Mathematics, and Sciences ...
(Date:1/15/2014)... Toronto, ON (PRWEB) January 15, 2014 ... an experimental new therapy for the treatment of tinnitus. ... unique tinnitus frequency, and over a period of weeks to ... Notched Sound Therapy in two forms: Notched Music and Notched ...
(Date:1/14/2014)... provider of strategic communications services to corporations and organizations preparing for ... United States and Europe , today ... to the firm,s Washington, D.C. office. ... years of service as Associate Commissioner for the Office of External ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management software, today ... In this role, Michelle will work with current and potential ... development of iLab products. Her main goal will be to ... scientific community by offering the most advanced, user-friendly, and high-impact ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... , which has promised Milwaukee that it can provide citywide ... reprieve by the Milwaukee Common Council after falling ... give Midwest Fiber until June 7 to hook up the ... The company was to have the area hooked up by ...
... this, about half of all Americans required to do so are scurrying ... in Sunday's Arizona Republic . For a lot of folks like ... back by two days this year, was indeed upon us. And we'd ... of tax laws changed this year. , ,The realization that Tax Day ...
... stuff of legends. Sit in any presentation by one ... PowerPoint slide you'll likely be convinced that the methodology ... itself, and eventually bring about world peace in our ... unique and special. When they are questioned about the ...
Cached Biology Technology:Turbo Tax Online can teach new Web concepts a business lesson 2Turbo Tax Online can teach new Web concepts a business lesson 3With tech implementations, it's NOT the methodology, stupid 2With tech implementations, it's NOT the methodology, stupid 3
... Novagen's HT96 Isothermal Block is an ... hold HT96 plates and to provide efficient ... plate. This new design of the HT96 ... offers an enhanced product design allowing for ...
Umbilical cord blood neutrophils, For immunohistochemistry (IHC)...
...
Adjustable tilt angle 0 to 20 Adjustable speed of 3-25 RPM Load capacity: 2.7 kg (6 lbs.) Ambient temperature range 4C to 65C Low voltage power is supplied by wall mount transformer...
Biology Products: