Navigation Links
Researchers discover trigger to early, effective antibody response
Date:7/6/2010

Dr. Torres and Cristina L. Swanson PhD, a postdoctoral fellow in his lab, studied a process that contains elements of both innate and adaptive immunity, known as the T-cell independent antibody response. While B cells are most widely recognized for their contributions to the adaptive immune response, some begin producing antibodies soon after an infection begins. Instead of detecting a single specific protein associated with the invader, they detect repetitive molecules linked together, such as those found in a bacterial cell wall or viral capsid.

This process has been studied for many years using synthetic molecules as model antigens. Drs. Torres Swanson thought that experiments using just the synthetic antigens did not accurately reflect what occurs in the real world. They reasoned that B cells would almost never encounter a bacterial cell wall or viral capsid alone; an intact cell wall would almost always also contain other molecules that activate the innate immune response as well. So the researchers decided to inject mice with the synthetic antigen plus a molecule that binds an innate receptor, known as TLR ligand. Dr. Swanson performed the majority of the experiments as part of her doctoral thesis work.

Striking results

The results were striking. Early antibody levels doubled when the TLR ligand was added. The mix of antibodies shifted as well, from 61 percent IgM to 82 percent IgG, which is a highly effective weapon against disease-causing organisms. The IgG levels remained elevated in mice for 182 days, as long as the researchers measured them. The long-lived persistence of this effective antibody suggests that the observations could be adapted to make more effective vaccines.

The researchers found that the TLR ligand spurred other cells to release type I interferon. That, in turn, activated follicular B cells to release the IgG antibodies. Prior to that, scientists had believed that follicular B cells partic
'/>"/>

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... California , 23 de septiembre de ... lanzamiento del Sistema 1290 Infinity II LC, ... de Infinity en su portafolio de cromatografía ... científicos y directores de laboratorio que alcancen ... excepcional, facilidad de uso y capacidad de ...
(Date:9/22/2014)... A new American Cancer Society study suggests that ... previously known as the food stamp program, had ... non-participants. The authors say the findings emphasize the ... dietary quality of SNAP participants. , The SNAP ... with the resources to obtain a nutritionally adequate ...
(Date:9/22/2014)... also known as tapioca, has large starch-filled roots and ... Asia, and Latin America where corn and sugarcane are ... and processes designed to break down tapioca starch into ... such as glucose, fructose, or maltose syrup, tapioca may ... a Review article in Industrial Biotechnology , a ...
Breaking Biology News(10 mins):Agilent Technologies anuncia el lanzamiento del Sistema 1290 Infinity II LC 2Agilent Technologies anuncia el lanzamiento del Sistema 1290 Infinity II LC 3Federal food program puts food on the table, but dietary quality could be improved 2
... menstruating have a weakening in the quality of their bone ... getting plenty of weight-bearing exercise, a new study finds. The ... Annual Meeting in Boston. "Given the high number of ... fact that up to 24% of young female athletes may ...
... Using the only microscope of its kind in Australia, ... see the inner workings of T-cells, the front-line troops that ... germs and other invaders in our bloodstream. The discovery ... T-cells into action a breakthrough that could lead to ...
... 2011 The International Development Research Centre (IDRC) together with ... Sciences and Engineering Research Council of Canada (NSERC), and ... (SSHRC) today announce that five research teams have been ... International Research Initiative on Adaptation to Climate Change (IRIACC). ...
Cached Biology News:Athletic girls more likely to have impaired bone structure if menstrual cycle stops 2Scientists use super microscope to pinpoint body’s immunity 'switch' 2International research initiative on adaptation to climate change announces research awards 2International research initiative on adaptation to climate change announces research awards 3
(Date:9/23/2014)... Sept. 23, 2014 News Facts ... India devoted to genome-based research for human health ... is taking a bite out of oral cancer with ... in India with the help of ... DataDirect Networks (DDN). , To fuel its cutting-edge cancer ...
(Date:9/23/2014)... , September 23, 2014 ... Closed System Transfer     Devices  (CSTD) ... partnership with Taiwanese distributor MedFront Medical Technology Corporation.  Equashield,s leading ... Taiwan , China ... the company continues to expand globally, and throughout ...
(Date:9/23/2014)... 2014 The Minnesota High Tech ... cellular modems , platforms and application-specific remote ... category for the 2014 Tekne Awards. The ... Minneapolis Convention Center on Thursday, November 13th. The ... have shown superior technology innovation and leadership. ...
(Date:9/22/2014)... DUBLIN , September 22, 2014 ... has announced the addition of the "Global ... offering.      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... are added to a system to detect and ... Reagents are generally used in laboratories to prepare, ...
Breaking Biology Technology:National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 2National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 3National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 4National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 5Equashield Enters Taiwan Following Expansion to Australia, Japan, China 2NimbeLink Named Finalist for 15th Annual Tekne Awards 2NimbeLink Named Finalist for 15th Annual Tekne Awards 3Global Biotechnology Reagents Market 2014-2018: Key Vendors are Agilent, BD Biosciences, Bio-Rad, F. Hoffmann-La Roche, Sigma-Aldrich and Thermo Fisher 2Global Biotechnology Reagents Market 2014-2018: Key Vendors are Agilent, BD Biosciences, Bio-Rad, F. Hoffmann-La Roche, Sigma-Aldrich and Thermo Fisher 3
... Oconomowoc-based IT services provider, announced Tuesday a new market ... July 1, the campaign will expand the PDS presence ... recently received Specialized Technology Partner Certifications from Cisco in ... partner; IP Communications, IP Communications Express, and Wireless. In ...
... When Hurricane Dennis reached landfall in the Florida ... surprising a development. Weather Central Inc. , a ... almost the exact location two days earlier. , ,On ... a service used by more than 100 television stations ...
... incubates a branding process, which can result in a random ... extreme name identity, whereupon a major advertising process kicks in. ... that's how we refer to today's trendy branding. To avoid ... various branding tricks and become aware of the bigger risks. ...
Cached Biology Technology:Accidental naming 2Accidental naming 3Accidental naming 4
ANXA11 Immunogen: ANXA11 (NP_001148, 406 a.a. ~ 506 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Anti-ADAM-12 (Meltrin Alpha); carboxy terminal end; rabbit host...
Anti-Flavocytochrome b Monoclonal, FITC Labeled Research Focus: other Storage: 4C Shipping Temperature: 4C...
Goat polyclonal to CHMP5 ( Abpromise for all tested applications). Antigen: Synthetic peptide: C-NKDGVLVDEFGLPQ, corresponding to C terminal amino acids 202-215 of Human CHMP5 Entrez GeneID: ...
Biology Products: