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Researchers discover the mechanism that determines cell position in the intestinal epithelium
Date:7/31/2011

ADAM10, which destroys the binding between distinct cell types, such as between cells from the bottom and surface of crypts. It is the destruction of these binding between cells from distinct compartments that prevents cell mixing, thus impeding once cell type from entering the wrong territory. In the words of Guiomar Solanas, first author of the article, "we have found the molecular mechanisms by which EphB receptors and their ligands tell each cell where it has to be throughout its life: from its generation from stem cells in the crypt bottom until its differentiation".

The loss of cell organization in a tissue is often associated with cancer. In addition to the loss of EphB receptor function in tumors is associated with a worse prognosis for patients. This new regulatory mechanism of affinity between cells types and territory maintenance could be key to our understanding of how less aggressive tumors evolve into malignant ones.


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Contact: Nuria Noriega
nuria.noriega@irbbarcelona.org
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert

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