Navigation Links
Researchers discover the mechanism that determines cell position in the intestinal epithelium
Date:7/31/2011

How do cells know where to position themselves and where to accumulate in order to carry out their functions correctly within each organ? Researchers with the Colorectal Cancer Lab at IRB Barcelona have revealed the molecular mechanisms responsible for organizing the intestinal epithelium into distinct comportments, defined by frontiers or territories. The study, headed by Eduard Batlle, coordinator of the Oncology Programme at IRB Barcelona and ICREA Research Professor, is published in today's online version of the Journal Nature Cell Biology, part of the prestigious editorial group Nature.

The organization of tissues and organs in the human body can be compared to a very complex and sophisticated engine, whose structure is maintained by positioning its components (cells) in a very precise way. Errors in the assembly (location) of the components might lead to changes in the function of the engine (tissue or organ).

New protein complexes that position cells in the right place

Complex tissues and organs require the separation of diverse cells types into separate zones in order to maintain their architecture. In the case of the intestinal epithelium, the lower part of the invaginations formed by the epithelium, called crypts, contains stem cells that regenerate tissue, while the upper part holds differentiated cells that are responsible for nutrient absorption.

The so-called EphB receptors, present in the cells at the bottom of the crypts, bind to Ephrin ligands located mainly in differentiated cells in the upper part of the intestinal epithelium. The ligand-receptor binding occurs at the frontier between the two cell populations and controls cell positioning in the tissue. However, until now, the way in which these ligand-receptor bindings instruct cells to position themselves in one place or another was unknown.

The results of this study demonstrate that EphB-ephrin bindings activate the metaloprotease
'/>"/>

Contact: Nuria Noriega
nuria.noriega@irbbarcelona.org
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert

Page: 1 2

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 22, 2014  The 2014 Holiday Season may ... as Acuity Market Intelligence reports that the long ... open. Acuity forecasts that intensifying demand for smart ... biometrics will drive a global market of 2.5 ... by 2020.   According to ...
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ... "Samsung Galaxy S5 - Home Button Synaptics Fingerprint ... http://photos.prnewswire.com/prnh/20130307/600769 ... than the iPhone 5S, Samsung introduces for the ... The Galaxy S5 home button presents ...
(Date:12/17/2014)... , Dec. 16, 2014  Automation is fundamentally ... more evident than at international borders. Over the ... scanners have allowed veteran travelers to self process ... Control (APC) Kiosks at an increasing number of ... According to Maxine Most ...
Breaking Biology News(10 mins):First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... men with hypertension found that men who drank moderately had reduced ... of wine, or a shot of liquor each counts as one ... linked to a lower risk of heart disease. But, since alcohol ... who have high blood pressure? , The new study, published ...
... for Allergy & Immunology (LIAI) announced today the results of ... worldwide on influenza A virus antibody and T cell epitopes. ... a virus that are the targets of the immune response, ... combat infectious disease. The study, using information from a ...
... 2005, the overall cost of patients' time spent on cancer care ... a new study in the January 3 issue of the ... the 11 cancers studied and for different phases of cancer care ... direct medical costs of cancer care, but few have attempted to ...
Cached Biology News:LIAI completes world's most comprehensive analysis on influenza virus data 2LIAI completes world's most comprehensive analysis on influenza virus data 3LIAI completes world's most comprehensive analysis on influenza virus data 4Study calculates patient time costs associated with cancer care 2Study calculates patient time costs associated with cancer care 3
(Date:12/19/2014)... Calif. , Dec. 19, 2014  Roche (SIX: ... of Bina Technologies, Inc. (Bina), a privately held ... , USA. Bina provides a big data ... generation sequencing (NGS) data. Bina,s proprietary on-market Genomic ... and academic researchers to perform fast and scalable ...
(Date:12/19/2014)... Arkansas (PRWEB) December 18, 2014 ... to locate its pilot production facility and future ... develop and produce innovative new materials that safely ... chosen not only because of its historic, strong ... leaders’ efforts to attract leading edge, technology-based companies ...
(Date:12/19/2014)... 19, 2014 In contrast to traditional ... with various colors, Valoya uses proprietary LED technology to ... best possible uniformity which is critical in low proximity ... spectral accuracy throughout its lifetime which is up to ... , "The investment cost was clearly higher when ...
(Date:12/19/2014)...   ISN has released its third annual ... publication series. With data aggregated from over eight ... within its online contractor management platform, ISNetworld, this three-part ... (KPI) statistics. The Contractor ... is available in two industry specific volumes: Oil ...
Breaking Biology Technology:Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3
... Caliper Life Sciences, Inc. (NASDAQ: CALP ... an innovative sequencing service provider based in Gaithersburg, Md. ... 5500xl, SOLiD 4, and Ion Torrent Personal Genome Machine ... initially focus on sample preparation for exome, whole genome, ...
... EMERYVILLE, Calif., June 27, 2011 MedeAnalytics, a ... announced the launch of its Patient Access Resource ... the front end of the revenue cycle, the ... performance indicators and industry trends, as well as ...
... 2011 Mediabrands, IPG Media Lab and Affectiva ... Festival, the results of the first annual Neuromarketing ... able to record and measure viewers, tacit, non-verbal ... individual,s facial features are established and are then ...
Cached Biology Technology:EdgeBio Selects Caliper's Sample Preparation Suite for High Throughput and Benchtop Sequencing Workflows 2The IPG Media Lab and Affectiva Announce Winners of First Annual Neuromarketing Awards 2The IPG Media Lab and Affectiva Announce Winners of First Annual Neuromarketing Awards 3
... of Total Canine Endostatin. Canine ... Science products include a line of ... and reagents used for multiple research ... kits are ultra-sensitive, quick and dependable ...
... Kit is a very sensitive immunohistochemical tool ... containing both anti-von Willebrand Factor and anti-CD31 ... variety of species. This AP kit provides ... of frozen and paraffin-embedded sections in human ...
... Many modifications of Eagle's ... the original formulation. The most ... Modified Eagle's,Medium. DME is a ... Eagle [MEM] that contains a ...
... OligoMix or individual RNA sequences from high throughput ... small RNAs from LC Sciences. These products provide ... millions) of DESIGNED sequences delivered in a microtube ... containing a single verified RNA sequence. This is ...
Biology Products: