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Researchers discover that gene switches on during development of epilepsy
Date:4/22/2009

within the research community because it shows up in the genetic makeup of some individuals with epilepsy. In other individuals, there is no genetic indication that they are capable of making extra copies of the channel.

"What we've shown is that this gene can be switched on in individuals who don't appear to have inherited the susceptibility," Godwin said.

The good news is that certain drugs can inhibit calcium channels, so, if researchers can determine that the over-expression of this calcium channel is solely responsible for seizure activity, future studies could look into the possibility of selectively inhibiting the channel with drugs, or even nutritional changes. Godwin explained that this study provided vital information but that more work needs to be done to translate the findings to human patients.


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Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center
Source:Eurekalert

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