Navigation Links
Researchers discover that gene switches on during development of epilepsy
Date:4/22/2009

WINSTON-SALEM, N.C. A discovery made by researchers at Wake Forest University School of Medicine while studying mice may help explain how some people without a genetic predisposition to epilepsy can develop the disorder.

In a study published this month in the Journal of Neuroscience, senior researcher Dwayne W. Godwin, Ph.D., a professor of neurobiology and anatomy, and colleagues, report discovering that a gene, already known to predispose people who inherit an active form of it to certain forms of epilepsy, can actually be "switched on" in animals that do not appear to have inherited the active form, and therefore a genetic predisposition, to the condition. The gene codes a calcium channel in the brain that underlies seizures, so the finding may reveal a mechanism by which epilepsy develops in those with no apparent genetic predisposition to it.

"Epilepsy is a terrible disorder that affects millions of kids and adults all over the world," Godwin said. "There are many different forms of epilepsy with different symptoms. We don't know why some people acquire epilepsy the cause isn't always clear from the person's genetic makeup. We do know that in some forms of epilepsy, once someone has a seizure they tend to have more. Our findings from this study suggest that something about the brain changes that can lead to this increased tendency to have a seizure. Our study shows that an important change occurs in calcium channels that help to transmit this abnormal activity throughout the brain."

Calcium channels come in a variety of forms throughout the body and are responsible for several key functions, depending on their placement and quantity. The calcium channels in the brain are normally embedded within the membrane of brain cells, where they allow passage of calcium ions into the cell and are responsible for the electrical activity of the brain. The passage of calcium ions into cells determines how excitable the cells are, and
'/>"/>

Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... captive black rhino reproduction in Europe highlights how ... programmes. , Researchers from Chester Zoo, The University ... out a six-year study which encompassed 90% of ... Edwards led the research as part of her ... "Although some black rhinoceros breed well in captivity, ...
(Date:8/22/2014)... CAEveryone,s heard of the birds and the bees. ... that are being fertilized. The fertilization process for ... communication between the male and female reproductive cells. ... Regensburg, Heidelberg, and Munich, and including Carnegie,s Wolf ... in the chemical signaling process that guides flowering ...
(Date:8/21/2014)... , Aug. 21, 2014 Nxt-ID, Inc. ... growing mobile commerce market, announced today that its shares ... stock to be issued in its proposed underwritten public ... for listing on The Nasdaq Capital Market, subject to ... common stock and warrants, and will trade under the ...
Breaking Biology News(10 mins):Hormone analysis helps identify horny rhinos 2Calcium and reproduction go together 2Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3
... A research team led by LSU Associate Professors of Biological ... of a combined field and laboratory study showing the effects ... Louisiana marshes. , The study, funded in part ... of Mexico Research Initiative is being published in the journal ...
... ... Presidential Early Career Award for Scientists and Engineers (PECASE). The award ... scientists and engineers in the early stages of their careers. ... significant award," said Jane Lubchenco, Ph.D., under secretary of commerce for ...
... , ASHEVILLE, NC A recent analysis of two ... (FIA) data shows the live volume of hemlocks in ... of hemlock woolly adelgid. FIA scientists from the Forest ... (NRS) published the information as an SRS e-Science Update ...
Cached Biology News:LSU researchers find impact of oil spill in marsh fish species 2President to honor high achieving, early career NOAA scientists 2Hemlocks still abundant despite adelgid infestations 2
(Date:8/22/2014)... August 22, 2014 Nerium International, ... is in the spotlight again. Nerium will showcase ... its NeriumFirmTM Body Contouring Cream to Hollywood’s elite ... Creations during the 66th Primetime Emmy® Awards. , ... extract, third-party clinical trials show that NeriumAD night ...
(Date:8/22/2014)... “Our nation's healthcare system is broken, ... Furthermore, every governmental and professional entity that has ... of unorganized dysfunction shares in that enormous blame. ... as a device to use in an effort ... have accumulated through the years leading to the ...
(Date:8/21/2014)... Hershey, PA & Rockville, MD (PRWEB) August 21, 2014 ... Inc. (ITI) is making progress in its development ... allergy to Japanese red cedar pollen. Phase IC studies ... to a real solution to hay fever. , The ... in over 35 million people in Japan. Mountain Cedar ...
(Date:8/21/2014)... including DESY scientists has observed tiny quantum vortices in ... the journal Science that the exotic vortices ... It is the first time that the quantum vortices, ... what is known as superfluid helium, have been detected ... says Andrey Vilesov of the University of Southern California, ...
Breaking Biology Technology:Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 35 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4Scientists observe quantum vortices in cold helium droplets 2
... - 11:00 a.m. ET; 8:00 a.m. PT, VANCOUVER ... (TSX: MGI; OTC: MGIFF), a clinical-stage developer of drugs ... on Tuesday,September 11, 2007 at 11:00 a.m. ET (8:00 ... quarter ended July 31, 2007. An update on,company activities ...
... Keynote Emphasizes Generic Industry Readiness and Questions Fiscal ... Social Responsibility of Delaying Biogenerics -, WASHINGTON, Sept. ... crossroads as decades-old patents,expire, and generic companies stand ready ... time to pass legislation enabling the U.S.,Food and Drug ...
... Sept. 6 NPS,Pharmaceuticals, Inc. (Nasdaq: NPSP ) ... for any and all of its outstanding 3.0% Convertible,Notes ... Eastern Time on,October 4, 2007, unless extended. The tender ... and the related letter of transmittal, is not,subject to ...
Cached Biology Technology:MIGENIX First Fiscal Quarter 2008 Financial Results Conference Call & Webcast Notification 2Biogenerics Will Save Billions, Says Hospira CEO 2Biogenerics Will Save Billions, Says Hospira CEO 3Biogenerics Will Save Billions, Says Hospira CEO 4NPS Pharmaceuticals Commences Tender Offer for 3.0% Convertible Notes Due 2008 2NPS Pharmaceuticals Commences Tender Offer for 3.0% Convertible Notes Due 2008 3NPS Pharmaceuticals Commences Tender Offer for 3.0% Convertible Notes Due 2008 4
...
... ISOQUANT(R) Isoaspartate Detection Kit is intended for ... proteins and peptides, which can result from ... rearrangement of aspartic acid residues during storage ... depend on the monitoring of charge differences ...
...
...
Biology Products: