Navigation Links
Researchers discover protein that controls bone growth
Date:12/19/2007

A research team led by Dr. Pierre Moffatt of the Shriners Hospital for Children in Montreal and McGill Universitys Department of Human Genetics has uncovered the molecular mechanism by which the protein osteocrin controls bone growth a discovery that may have important implications for people suffering from bone diseases affecting skeletal growth. The teams findings appear in the December 14 edition of the Journal of Biological Chemistry.

Osteocrin is a small protein produced by the bodys bone-forming cells, or osteoblasts. In this study, mice that were genetically engineered to over-express osteocrin developed hunchbacks and elongated bones. This led Dr. Moffatt and his colleagues to the discovery that osteocrin locally controls the bone's supply of a hormone known as CNP, which plays an important role in the regulation of bone growth.

The osteocrin gene was discovered as part of a project to identify novel bone genes that might have possible therapeutic actions, explained Dr. Moffatt. "The project focused on the identification of classes of genes which are particularly attractive to medical researchers because they can be potentially exploited to develop new drug-based therapies."

Most of the research was initially carried out at Phenogene and Enobia Pharma, two Montreal-based biotech companies, but it was finalized in Dr. Moffatts lab at the Shriners Hospital for Children in Montreal.

This fundamental research could pave the way to the rationalized design of new molecules which could have beneficial effects in various disorders that impair bone growth, particularly in children, said Dr. Moffatt.


'/>"/>

Contact: Mark Shainblum
mark.shainblum@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... April 24, 2017 Janice Kephart ... with  Identity Strategy Partners, LLP (IdSP) , today ... without President Trump,s March 6, 2017 Executive ... , refugee vetting can be instilled with greater confidence, ... now, all refugee applications are suspended by until ...
(Date:4/13/2017)... April 13, 2017 According to a new market ... Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, ... Market is expected to grow from USD 14.30 Billion in 2017 to ... of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), Biometrics, Card-Based ... & Logistics, Government & Public Sector, Utilities / Energy ... Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality & ... for a definitive report on the $27.9bn Access Control ... ...
Breaking Biology News(10 mins):
(Date:6/26/2017)... ... June 26, 2017 , ... The Workgroup for Electronic Data Interchange (WEDI) ... efficiencies in healthcare information exchange and a statutory advisor to the U.S. Department of ... federal Office of the National Coordinator for Health Information Technology, will deliver the keynote ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... the latest version of LimitLIS®, its rapidly growing Laboratory Information System. , LimitLIS® ... adoption, ensure installation integrity, and provide more customization options. Each of these has ...
(Date:6/23/2017)... ... 2017 , ... The Academy of Model Aeronautics (AMA), the ... (UAA), the unifying voice for collegiate aviation education, are launching a joint UAS ... success through a STEM-based education platform. , Much like the program currently available ...
(Date:6/22/2017)... ... June 21, 2017 , ... Building on the success of the inaugural ... on the very latest developments in radical life extension. RAADfest combines cutting edge science ... the empowerment of personal development, making it the largest most comprehensive and inclusive super ...
Breaking Biology Technology: