Navigation Links
Researchers discover potential cause of chronic painful skin
Date:6/8/2011

June 6, 2011 (Rensselaer, N.Y., USA) A new study may explain why only 50% of patients experiencing chronic nerve pain achieve even partial relief from existing therapeutics. The study, published in the June 6 online version of the international research journal PAIN, reveals that certain types of chronic pain may be caused by signals from the skin itself, rather than damage to nerves within the skin, as previously thought.

A Medical Mystery

For years, researchers have known that increased amounts of a molecule called Calcitonin Gene-Related Peptide (CGRP) is found in the skin of chronic pain patients. The source of the increased CGRP was thought to be certain types of sensory nerve fibers in the skin that normally make and release a type or "isoform" called CGRP-alpha. Curiously, however, the authors of the current study found that nerve fibers containing CGRP-alpha are actually reduced under painful conditions leading them to investigate where the increased CGRP in the skin came from.

The answer, surprisingly, was that the skin cells themselves generate increased amounts of a lesser-known "beta" isoform of CGRP. This skin cell-derived CGRP-beta is increased in painful conditions and may be sending pain signals to remaining sensory nerve fibers in the skin. The discovery of CGRP-beta as a therapeutic target presents a potentially important new treatment approach.

"Since CGRP-alpha normally plays an important role in both the regulation of blood flow and normal inflammatory responses, targeting this molecule as a treatment for chronic pain could cause undesired side-effects on circulation," said the paper's corresponding author, Phillip J. Albrecht, Ph.D., Assistant Professor of Neuroscience at Albany Medical College and Vice President at Integrated Tissue Dynamics, LLC, whose team conducted the research. "However, since we know that these two forms of CGRP are derived from separate genes, we may be able to
'/>"/>

Contact: Alex Brownstein
alexb@intidyn.com
866-610-7581 x104
Integrated Tissue Dynamics (INTIDYN)
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers discover potential cause of chronic painful skin
(Date:2/5/2015)... Calif. , Feb. 3, 2015 ... technology, demand from industries such as consumer electronics, ... market for surface mount technology (SMT) screen printers. ... to automatic control will push the adoption curve ... will remain steady as glue dispensers are indispensable ...
(Date:1/22/2015)... MELBOURNE, Fla. , Jan. 13, 2015  Today, ... wearable technology, launched its crowdfunding campaign on Fundable, ... accelerate the build of production capacity to meet ... Photo - http://photos.prnewswire.com/prnh/20150113/168790 ...
(Date:1/22/2015)... (NASDAQ: NXTD and NXTDW) a biometric authentication company focused ... the Wocket™ smart wallet at CES 2015 in Las Vegas ... of the "11 Hot Products at CES" in a review published in ... by Newseveryday.com and "The top 10 gadgets from CES 2015" by ...
Breaking Biology News(10 mins):End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 2End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 3FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... MADISON People get type 2 diabetes. So do cats. ... in the shape of proteins protect some and endanger others. ... it only differs a little bit from species to species," ... mammals that get type 2 diabetes, their amylin proteins aggregate ...
... Energy is making good on the second phase of a plant ... by Dr. Joshua Yuan, Texas A&M AgriLife Research plant pathologist., ... Yuan, who was granted $1.8 million for Phase I by the ... source., The scientist said his research is moving ahead so quickly ...
... the Earth has reached the limits of its biophysical ... and social norms relating to material production and consumption ... functioning of our planet,s life support systems. ... pivotal role to play in this transition. This timely ...
Cached Biology News:New look identifies crucial clumping of diabetes-causing proteins 2Plant fuel project moves to second phase under US Energy Department grant 2
(Date:3/2/2015)... March 2, 2015 VG Life Sciences, ... for autoimmune and infectious diseases, announced that the ... an important new composition of matter patent covering ... targeting of CLIP. U.S. Patent ... VG Life Sciences, VG1177, a synthetic peptide which ...
(Date:3/2/2015)... Global Stem Cells Group.com has ... Bioengineering Co., Ltd. and its Chinese-American founder Mingjie ... stem cells training course in the City of ... Shenzhen HANK is a biotechnology company established in ... virologist, to integrate research, development, production, and sales ...
(Date:3/1/2015)... 01, 2015 Market Publishers Ltd ... quality market research promotion on Internet. MarketPublishers.com is ... worked out by DataGroup Booksellers. , Natalie Aster, ... Ltd, commented on the recent partnership agreement as ... in our team of publishers. Since 1974, the ...
(Date:2/27/2015)... Halifax, Nova Scotia (PRWEB) February 27, 2015 ... has been made aware of a fraudulent press release ... GlobeNewswire, purporting to be from Immunovaccine. This press release ... with Gilead Science, Inc. The press release did ... to the information contained within the press release. ...
Breaking Biology Technology:VG Life Sciences Granted Key Composition Of Matter Patent 2VG Life Sciences Granted Key Composition Of Matter Patent 3Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 2Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 3Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 2Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 3Immunovaccine Disclaims Hoax Press Release 2
... As adjunctive therapy Keppra XR(TM) offers significant partial onset ... ... heritage, ATLANTA, Sept. 15 press release, regulated information:,UCB ... has,approved Keppra XR(TM) (levetiracetam extended-release tablets) for use as,an add-on ...
... Diagnostics, Inc. today,announced the appointment of Johan Skog, ... Dr. Skog will oversee the research program that,underlies ... can,identify cancer-specific genetic mutations., Dr. Skog is ... technology that has been licensed exclusively to the ...
... milestone payments and promotional investment totaling up to ... $385 million ... CV Therapeutics,Inc. (Nasdaq: CVTX ) announced today that it ... prolonged release,tablets) in Europe and other countries to the Menarini ...
Cached Biology Technology:Video: Keppra XR(TM) Approved in the U.S. 2Video: Keppra XR(TM) Approved in the U.S. 3Video: Keppra XR(TM) Approved in the U.S. 4CV Therapeutics Announces License Agreement for Ranexa(R) in Europe With Menarini Group 2CV Therapeutics Announces License Agreement for Ranexa(R) in Europe With Menarini Group 3CV Therapeutics Announces License Agreement for Ranexa(R) in Europe With Menarini Group 4CV Therapeutics Announces License Agreement for Ranexa(R) in Europe With Menarini Group 5
Bovine Serum Albumin Peroxidase Stabilizer Solution, 1 L...
... an agarose-digesting enzyme isolated from Pseudomonas ... bonds in agarose producing carbohydrate molecules ... remaining carbohydrate molecules will not interfere ... with Gelzyme enzyme can be used ...
...
Coverslips for Microarrays, 1. *Category: MICROARRAY ACCESSORIES....
Biology Products: