Navigation Links
Researchers discover novel anti-viral immune pathway in the mosquito

As mosquito-borne viral diseases like West Nile fever, dengue fever, and chikungunya fever spread rapidly around the globe, scientists at Virginia Tech are working to understand the mosquito's immune system and how the viral pathogens that cause these diseases are able to overcome it to be transmitted to human and animal hosts.

In nearly every part of the world, humans and animals experience high levels of morbidity and mortality after being bitten by mosquitoes infected with viruses. More than 100 different viruses transmitted by blood feeding arthropods like mosquitoes have been associated with human or animal disease.

Two especially prolific vectors are the yellow fever mosquito (Aedes aegypti) and Asian tiger mosquito (Aedes albopictus), which is easy to spot because of its striped patterning. Although native to Africa and Asia, these insects can spread through the western world by hitching rides in used tires, which trap water to create a perfect breeding site.

Virginia Tech researchers have identified a novel anti-viral pathway in the immune system of culicine mosquitoes, the insect family to which both vectors belong. Kevin Myles and Zach Adelman, both associate professors of entomology in the College of Agriculture and Life Sciences, lead the research, which is published in the Jan . 5 PLoS Pathogens article, "Production of Virus-Derived Ping-Pong-Dependent piRNA-like Small RNAs in the Mosquito Soma," by Elaine M. Morazzani and Michael R. Wiley, Ph.D. students in entomology; Marta G. Murreddu, research associate in entomology; and Adelman; and Myles.

"We have previously shown that an antiviral response directed by small interfering RNAs (siRNAs) is present in culicine mosquito vectors. However, we show here that another class of virus-derived small RNAS, exhibiting many similarities with ping-pong-dependent piwi-interacting RNAs (piRNAs) is also produced in the soma of culicine mosquitoes," the authors explain. Myles, Adelman, and co-workers made use of a technique called next generation sequencing to aid in their discovery.

The newly discovered antiviral pathway appears to act redundantly to the previously described small interfering RNA (siRNA) pathway, indicating a robust immune system, said Myles. Thus, understanding how viruses get around the mosquito's dual antiviral responses poses an increasingly interesting challenge to scientists.

"In the case of mosquito-borne pathogens, our health depends as much on the mosquito's immune response as it does on our own immune response, yet surprisingly little is known about the immune system of the mosquito," Myles said.


Contact: Lindsay Key
Virginia Tech

Related biology news :

1. MU researchers find unique protein organization in arteries associated with cardiovascular disease
2. Frogs use calls to find mates with matching chromosomes, University of Missouri researchers find
3. Viagra against heart failure: Researchers at the RUB and from Rochester throw light on the mechanism
4. DOE researchers achieve important genetic breakthroughs to help develop cheaper biofuels
5. Drugs used to overcome cancer may also combat antibiotic resistance: McMaster researchers
6. Researchers develop new method of cleaning toxins from the oilsands
7. Researchers discover a way to significantly reduce the production costs of fuel cells
8. San Diego Zoo researchers contribute to project using mummy DNA to differentiate croc species
9. Researchers create living neon signs composed of millions of glowing bacteria
10. Georgetown researchers lead discovery expected to significantly change biomedical research
11. 4 UC Riverside researchers receive national recognition
Post Your Comments:
Related Image:
Researchers discover novel anti-viral immune pathway in the mosquito
(Date:6/15/2016)... 15, 2016 Transparency Market ... Recognition Market by Application Market - Global Industry Analysis Size ... to the report, the  global gesture recognition market ... and is estimated to grow at a CAGR ... 2024.  Increasing application of gesture recognition ...
(Date:6/3/2016)... 3, 2016 Das ... Nepal hat ein 44 ... geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, ... Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte ... Januar teilgenommen, aber Decatur wurde als konformste ...
(Date:6/1/2016)... , June 1, 2016 ... in Election Administration and Criminal Identification to Boost Global ... a recently released TechSci Research report, " Global Biometrics ... Region, Competition Forecast and Opportunities, 2011 - 2021", the ... billion by 2021, on account of growing security concerns ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the leading software as ... Clinical Reach Virtual Patient Encounter CONSULT module which enables both audio and video ... trial team. , Using the CONSULT module, patients and physicians can schedule a face ...
(Date:6/27/2016)... , June 27, 2016  Liquid Biotech ... the funding of a Sponsored Research Agreement with ... tumor cells (CTCs) from cancer patients.  The funding ... CTC levels correlate with clinical outcomes in cancer ... data will then be employed to support the ...
(Date:6/24/2016)... SAN DIEGO , June 24, 2016 /PRNewswire/ ... that more sensitively detects cancers susceptible to PARP ... individual circulating tumor cells (CTCs). The new test ... of HRD-targeted therapeutics in multiple cancer types. ... therapies targeting DNA damage response pathways, including PARP, ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a leader ... “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research professionals, ... providing practical tips, tools, and strategies for clinical researchers. , “The landscape of ...
Breaking Biology Technology: