Navigation Links
Researchers discover novel anti-viral immune pathway in the mosquito
Date:1/10/2012

As mosquito-borne viral diseases like West Nile fever, dengue fever, and chikungunya fever spread rapidly around the globe, scientists at Virginia Tech are working to understand the mosquito's immune system and how the viral pathogens that cause these diseases are able to overcome it to be transmitted to human and animal hosts.

In nearly every part of the world, humans and animals experience high levels of morbidity and mortality after being bitten by mosquitoes infected with viruses. More than 100 different viruses transmitted by blood feeding arthropods like mosquitoes have been associated with human or animal disease.

Two especially prolific vectors are the yellow fever mosquito (Aedes aegypti) and Asian tiger mosquito (Aedes albopictus), which is easy to spot because of its striped patterning. Although native to Africa and Asia, these insects can spread through the western world by hitching rides in used tires, which trap water to create a perfect breeding site.

Virginia Tech researchers have identified a novel anti-viral pathway in the immune system of culicine mosquitoes, the insect family to which both vectors belong. Kevin Myles and Zach Adelman, both associate professors of entomology in the College of Agriculture and Life Sciences, lead the research, which is published in the Jan . 5 PLoS Pathogens article, "Production of Virus-Derived Ping-Pong-Dependent piRNA-like Small RNAs in the Mosquito Soma," by Elaine M. Morazzani and Michael R. Wiley, Ph.D. students in entomology; Marta G. Murreddu, research associate in entomology; and Adelman; and Myles.

"We have previously shown that an antiviral response directed by small interfering RNAs (siRNAs) is present in culicine mosquito vectors. However, we show here that another class of virus-derived small RNAS, exhibiting many similarities with ping-pong-dependent piwi-interacting RNAs (piRNAs) is also produced in the soma of culicine mosquitoes," the authors explain. Myles, Adelman, and co-workers made use of a technique called next generation sequencing to aid in their discovery.

The newly discovered antiviral pathway appears to act redundantly to the previously described small interfering RNA (siRNA) pathway, indicating a robust immune system, said Myles. Thus, understanding how viruses get around the mosquito's dual antiviral responses poses an increasingly interesting challenge to scientists.

"In the case of mosquito-borne pathogens, our health depends as much on the mosquito's immune response as it does on our own immune response, yet surprisingly little is known about the immune system of the mosquito," Myles said.


'/>"/>

Contact: Lindsay Key
ltkey@vt.edu
540-231-6594
Virginia Tech
Source:Eurekalert  

Related biology news :

1. MU researchers find unique protein organization in arteries associated with cardiovascular disease
2. Frogs use calls to find mates with matching chromosomes, University of Missouri researchers find
3. Viagra against heart failure: Researchers at the RUB and from Rochester throw light on the mechanism
4. DOE researchers achieve important genetic breakthroughs to help develop cheaper biofuels
5. Drugs used to overcome cancer may also combat antibiotic resistance: McMaster researchers
6. Researchers develop new method of cleaning toxins from the oilsands
7. Researchers discover a way to significantly reduce the production costs of fuel cells
8. San Diego Zoo researchers contribute to project using mummy DNA to differentiate croc species
9. Researchers create living neon signs composed of millions of glowing bacteria
10. Georgetown researchers lead discovery expected to significantly change biomedical research
11. 4 UC Riverside researchers receive national recognition
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers discover novel anti-viral immune pathway in the mosquito
(Date:3/22/2016)... , March 22, 2016 ... report "Electronic Sensors Market for Consumer Industry by Type ... Others), Application (Communication & IT, Entertainment, Home ... Global Forecast to 2022", published by MarketsandMarkets, ... expected to reach USD 26.76 Billion by ...
(Date:3/17/2016)... March 17, 2016 ABI Research, the ... the global biometrics market will reach more than ... increase from 2015. Consumer electronics, particularly smartphones, continue ... sensors anticipated to reach two billion shipments by ... Dimitrios Pavlakis , Research Analyst at ABI Research. ...
(Date:3/14/2016)... HANOVER , Allemagne, March 14, 2016 /PRNewswire/ ... http://www.apimages.com ) - --> - ... ) - --> ... les solutions biométriques, fournit de nouveaux lecteurs d,empreintes ... lecteur LF10 de DERMALOG sera utilisé pour produire ...
Breaking Biology News(10 mins):
(Date:5/24/2016)... ... 2016 , ... Last week, Callan Capital, an integrated wealth management firm specializing ... of San Diego Life Science event at the Estancia La Jolla Resort and Spa. ... with speakers Dr. Rich Heyman, former CEO of Aragon and Seragon, and Faheem Hasnain, ...
(Date:5/23/2016)... ... 23, 2016 , ... The need for blood donations in South Texas and across the nation ... Blood & Tissue Center, blood donations are on the decline. In fact, donations across the ... 21 percent in South Texas in the last four years alone. , There is no ...
(Date:5/23/2016)... , May 23, 2016 Zimmer Biomet Holdings, ... healthcare, today announced that its Board of Directors has approved ... the second quarter of 2016. The cash ... about July 29, 2016 to stockholders of record as of ... of dividends are subject to approval of the Board of ...
(Date:5/23/2016)... LONDON , May 23, 2016 ... Efficiency by 40% - Frontage Implement a Single Platform ... Quality, Compliance and Traceability Within the Bioanalytical lab Frontage ... the United States and China ... across its laboratory facilities. In addition to serving as the global ...
Breaking Biology Technology: