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Researchers discover new strategies for antibiotic resistance
Date:8/29/2007

pecific sites within these molecules.

To do so, the y core structure often contains a "b bulge" motif a region that affords structural variations otherwise prohibited in protein biochemistry.

"The ability of host defense molecules to change so quickly and with such diversity may be natures way of keeping pace with rapidly evolving infectious microbes and other threats," said Dr. Yount.

These insights may drive new strategies for anti-infective discovery and development. Drs. Yeaman and Yount also said their discoveries significantly advance understanding of immune system evolution. Microbial pathogens are constantly moving targets; in turn immune systems must adapt or lose effectiveness. Understanding how these molecules have continued to ward off infection could also accelerate development of immunotherapeutics to boost the bodys own defenses against infection or other diseases, and reduce the resistance issues that plague todays antibiotics.


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Contact: Laura Mecoy
lmecoy@issuesmanagement.com
310-546-5860
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)
Source:Eurekalert

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