Navigation Links
Researchers discover new strategies for antibiotic resistance
Date:8/29/2007

TORRANCE (August 29, 2007) - With infections increasingly resistant to even the most modern antibiotics, researchers at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) report in the September issue of Nature Reviews Microbiology on new clues they have uncovered in immune system molecules that defend against infection.

Drs. Michael R. Yeaman and Nannette Y. Yount present evidence that small proteins in the immune systems of humans and all kingdoms of life share fundamental structural and functional characteristics that enable these molecules to inhibit or kill microbial pathogens even as these pathogens evolve to resist conventional antibiotics.

"These findings reveal that nature uses a recurring molecular strategy to defend against infection," said Dr. Yeaman. "A clearer understanding of this strategy provides new opportunities to develop innovative anti-infective therapies to better prevent or treat life-threatening infections that resist current antibiotics."

Most modern antibiotics work by targeting specific structures or functions in microbial pathogens. If the targets change due to mutation, pathogens can quickly become resistant to the antibiotics. In contrast, immune system molecules have retained the ability to fight infection even as microbes evolve.

"While human ingenuity has thus far created antibiotics that pathogens seem to resist after just a few years, nature has created molecules in our immune systems that retain the ability to defend against infection even after millions of years of evolution," said Dr. Yeaman. "We have a lot to learn from nature."

The September article sheds new light on the molecular basis for the antimicrobial capabilities of these molecules. Drs. Yeaman and Yount report that a structure they discovered in these molecules in 2004 known as the y core allows for "hypermutability," or unusually high rates of mutation or modification at specific sites within these molecules.

To do so, the y core structure often contains a "b bulge" motif a region that affords structural variations otherwise prohibited in protein biochemistry.

"The ability of host defense molecules to change so quickly and with such diversity may be natures way of keeping pace with rapidly evolving infectious microbes and other threats," said Dr. Yount.

These insights may drive new strategies for anti-infective discovery and development. Drs. Yeaman and Yount also said their discoveries significantly advance understanding of immune system evolution. Microbial pathogens are constantly moving targets; in turn immune systems must adapt or lose effectiveness. Understanding how these molecules have continued to ward off infection could also accelerate development of immunotherapeutics to boost the bodys own defenses against infection or other diseases, and reduce the resistance issues that plague todays antibiotics.


'/>"/>
Contact: Laura Mecoy
lmecoy@issuesmanagement.com
310-546-5860
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)
Source:Eurekalert

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. NYU researchers simulate molecular biological clock
5. Researchers reveal the infectious impact of salmon farms on wild salmon
6. Researchers identify target for cancer drugs
7. Vital step in cellular migration described by UCSD medical researchers
8. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
9. UCSD researchers maintain stem cells without contaminated animal feeder layers
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2019)... , ... May 24, 2019 , ... The newest edition ... is now available on the company’s global website. , Crystallography Times is a monthly ... X-ray diffraction. It serves the X-ray analysis community by presenting the latest news and ...
(Date:5/22/2019)... ... May 22, 2019 , ... Leak Detection Associates (LDA), the ... the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is excited to announce ... Ltd has been signed. The agreement will grant exclusive rights for IPP ...
(Date:5/21/2019)... (PRWEB) , ... May 21, 2019 , ... ... technology and biotech companies, turned 20 today, and to celebrate launched a new ... with the foundational tools they need – pre-product – to attract talent and ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... Va. (PRWEB) , ... June 11, 2019 , ... ... microlearning engagement, and Carilion Clinic, a national leader in opioid treatment, announced today ... virtual care. , Mytonomy recently deployed its virtual care platform at ...
(Date:6/6/2019)... Calif. (PRWEB) , ... June 05, 2019 , ... ... biotechnology and medical device industries, announced today that they will be receiving 3 awards ... San Diego, CA. WCCT received 2 awards in the categories of overall Quality and ...
(Date:5/31/2019)... ... 30, 2019 , ... World Compliance Seminars today announced a ... in Boston, MA. This peer recommended interactive workshop is always selected by professionals ... kick off with a compendial treatment of Data Integrity fundamentals. After laying the ...
(Date:5/22/2019)... ... 2019 , ... Artemis (formerly Agrilyst), the leading enterprise Cultivation Management ... co-led by Astanor Ventures and Talis Capital with participation from ... Fund . The company has raised $11.75m to date and will use the new ...
Breaking Biology Technology: