Navigation Links
Researchers discover mechanism that limits scar formation
Date:6/10/2010

Researchers from the University of Illinois at Chicago have discovered that an unexpected cellular response plays an important role in breaking down and inhibiting the formation of excess scar tissue in wound healing.

Their study was published online this week in Nature Cell Biology.

When an organism suffers severe injury, specialized cells are "recruited" to the wound site that rapidly produce extracellular matrix proteins such as collagen to provide structural support to the tissue, according to Lester Lau, professor of biochemistry and molecular biology at the UIC College of Medicine and principal investigator in the study.

Joon-Il Jun, a postdoctoral fellow working in Lau's lab and first author of the paper, found that fibroblasts recruited to the site of skin wounds were entering a state of reproductive dormancy, or cell-cycle arrest, called senescence.

This was quite unexpected, Jun said. Until now senescence was believed to occur in cells that suffered DNA damage -- to prevent them from proliferating and, possibly, becoming cancerous.

He discovered that the senescent fibroblasts were making proteins that degraded the extracellular matrix and accelerated the breakdown of collagen. The senescent cells also stopped making collagen.

"The accumulation of senescent cells in the wound has the biological effect of inhibiting the formation of excess scar tissue," Jun said.

Jun also discovered that a protein called CCN1 is responsible for turning on the senescent state in fibroblasts. He was able to show that in mice with a mutated, non-functional form of CCN1, the fibroblasts at the site of a skin wound did not become senescent, and the wound developed excessive scar tissue.

Further, Jun was able to "rescue" the mutated mice by applying CCN1 protein topically to the skin wound, triggering fibroblast senescence and limiting the formation of scar tissue.

The discovery that senes
'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify gene linked to hereditary incontinence
2. UCLA stem cell researchers uncover previously unknown patterns in DNA methylation
3. Lasers help researchers predict birds preferred habitat
4. Researchers find gene linked to birth defects
5. Yale researchers develop test to identify best sperm
6. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
7. UCI researchers create retina from human embryonic stem cells
8. Discovery may lead to safer drinking water, cheaper medicine: Queens University researchers
9. Researchers discover new mechanism for clearing blockages from smallest blood vessels
10. Researchers calculate the greenhouse gas value of ecosystems
11. Queens researchers reveal parasitic threat to animals and the environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... , April 2, 2015 ... DERMALOG by far outperforms the strongest competitors, showing ... high accuracy, the system is capable of a ... speed proves up to be ten times faster ... its runner-up performance.      (Photo: ...
(Date:4/2/2015)... , April 2, 2015 According ... 2015 attributed to somewhat higher than 125 MSEK. This ... year-end report 2014 that revenues for Q1 2015 would ... company reported for Q4 2014. The operating result for ... negative. The complete interim report will as previously communicated ...
(Date:4/1/2015)... Conn. , Apr. 1, 2015  NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... of Wocket smart wallets is underway to early access ... access group includes usage at retail outlets including Walmart, ... Pharmacy. Users report Wocket was accepted at all outlets ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Revises Revenues for Q1 2015 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
... helped develop an antioxidant supplement which may slow down ... help those affected by the leading cause of blindness ... found. , Professor Usha Chakravarthy, from Queen,s Centre of ... looked at nutritional supplements for patients with early age-related ...
... and insufficient law enforcement mean that Thailand continues ... Asia, says a new report from the wildlife ... raises concerns that legal provisions governing trade in ... in wild-caught, highly-endangered Asian elephants from both Thailand ...
... tracking polar bears, developed by Queen,s University researchers, will ... and help boost the economy of Canada,s north. ... state-of-the-art genetic DNA analysis, a three-part method developed by ... cheaper and much easier on the bears than the ...
Cached Biology News:New supplement may help slow sight loss in elderly 2Elephant-size loopholes sustain Thai ivory trade 2New tracking approach will help protect polar bears 2
(Date:4/17/2015)... 17, 2015 Reed Technology and ... regulatory data management, preparation, and submission to the U.S. ... of a new Lot Distribution Report (LDR) service for ... remain compliant with the FDA’s new rule on electronic ... to monitor the volume and timing of particular biologics ...
(Date:4/17/2015)... 17, 2015 Global Stem Cells ... Stem Cell Summit 2015 April 27 - 29, 2015 ... developments in all areas of stem cell research including ... cells and regenerative medicine. , The conference will ... well as translational research in stem cell therapies, regenerative ...
(Date:4/16/2015)... 2015 Cambridge Semantics , ... by Semantic Web technology, and Informa , ... services for the academic and scientific, professional and ... solution ‘Smart Data Lake for Clinical Trial and ... 2015 Bio-IT ‘Best of Show’ Award. , ...
(Date:4/16/2015)... (PRWEB) April 16, 2015 Regis Technologies ... American Association for Cancer Research (AACR) annual meeting. Regis ... Convention Center, starting Saturday, April 18, in Philadelphia and ... claim to title of the oldest and largest organization ... fellowships and grants, and partners with survivors to promote ...
Breaking Biology Technology:Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 3Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 2Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 3Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3Regis Technologies Joins American Association for Cancer Research Annual Meeting 2
... Calif., Jan. 7 Nuvelo, Inc.,(Nasdaq: ... Nuvelo have approved,the issuance of Nuvelo Common Stock ... as amended, between Nuvelo, ARCA biopharma and a ... special,stockholder meeting until January 23, 2009, to solicit ...
... Corporation,(Nasdaq: VOLC ), a leader in the ... treatment of coronary and peripheral artery,disease, said today that ... Inc. , Axsun is a ... in medical Optical Coherence Tomography (OCT) imaging systems and,advanced ...
... 7 Cold season has settled in for the,winter ... cause for doctor,appointments and missed days of school and ... boost your immune system. And Immunity Enhanced Beverage is ... Recently introduced by Innovative Beverage Products, Immunity Enhanced,Beverage is ...
Cached Biology Technology:Nuvelo Shareholders Approve Issuance of Common Stock Pursuant to Merger Agreement With ARCA biopharma 2Nuvelo Shareholders Approve Issuance of Common Stock Pursuant to Merger Agreement With ARCA biopharma 3Nuvelo Shareholders Approve Issuance of Common Stock Pursuant to Merger Agreement With ARCA biopharma 4Nuvelo Shareholders Approve Issuance of Common Stock Pursuant to Merger Agreement With ARCA biopharma 5Volcano Announces Closing of Axsun Technologies Acquisition 2Innovative Beverage Products Launches New Product Designed to Enhance the Body's Immune Defense 2
... Solid phase reagent for ... Easy & unique water ... with detergents and chaotropes; ... recover non-envelop viruses while ...
Mouse monoclonal [Ley 37D/G6] to LKB1 ( Abpromise for all tested applications). entrezGeneID: 6794 SwissProtID: Q15831...
Non-Receptor Tyrosine Kinase Sampler Kit 10 mu g each...
Mouse monoclonal [3A7.A11] to Thymidylate Synthase ( Abpromise for all tested applications). entrezGeneID: 7298 SwissProtID: P04818...
Biology Products: