Navigation Links
Researchers discover mechanism that limits scar formation
Date:6/10/2010

Researchers from the University of Illinois at Chicago have discovered that an unexpected cellular response plays an important role in breaking down and inhibiting the formation of excess scar tissue in wound healing.

Their study was published online this week in Nature Cell Biology.

When an organism suffers severe injury, specialized cells are "recruited" to the wound site that rapidly produce extracellular matrix proteins such as collagen to provide structural support to the tissue, according to Lester Lau, professor of biochemistry and molecular biology at the UIC College of Medicine and principal investigator in the study.

Joon-Il Jun, a postdoctoral fellow working in Lau's lab and first author of the paper, found that fibroblasts recruited to the site of skin wounds were entering a state of reproductive dormancy, or cell-cycle arrest, called senescence.

This was quite unexpected, Jun said. Until now senescence was believed to occur in cells that suffered DNA damage -- to prevent them from proliferating and, possibly, becoming cancerous.

He discovered that the senescent fibroblasts were making proteins that degraded the extracellular matrix and accelerated the breakdown of collagen. The senescent cells also stopped making collagen.

"The accumulation of senescent cells in the wound has the biological effect of inhibiting the formation of excess scar tissue," Jun said.

Jun also discovered that a protein called CCN1 is responsible for turning on the senescent state in fibroblasts. He was able to show that in mice with a mutated, non-functional form of CCN1, the fibroblasts at the site of a skin wound did not become senescent, and the wound developed excessive scar tissue.

Further, Jun was able to "rescue" the mutated mice by applying CCN1 protein topically to the skin wound, triggering fibroblast senescence and limiting the formation of scar tissue.

The discovery that senescence is a normal wound-healing response in the skin; that senescence in the wound serves an anti-fibrotic function; and that CCN1 is the critical protein that controls this process may prove important in understanding a wide range of pathological conditions related to tissue scarring, said Lau.

"For example, chronic injury to the liver from a number of causes, including viral infections, alcoholism, diabetes and obesity, leads to fibrosis and may progress to cirrhosis," Lau said. "After a heart attack, accumulation of scar tissue in the heart impairs its ability to pump efficiently."

The ability to control the formation of scar tissue, or fibrosis, has important implications for future therapies for treating wound-healing disorders, including organ damage where functional tissue is replaced with scar tissue, Lau said.


'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Related biology news :

1. Researchers identify gene linked to hereditary incontinence
2. UCLA stem cell researchers uncover previously unknown patterns in DNA methylation
3. Lasers help researchers predict birds preferred habitat
4. Researchers find gene linked to birth defects
5. Yale researchers develop test to identify best sperm
6. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
7. UCI researchers create retina from human embryonic stem cells
8. Discovery may lead to safer drinking water, cheaper medicine: Queens University researchers
9. Researchers discover new mechanism for clearing blockages from smallest blood vessels
10. Researchers calculate the greenhouse gas value of ecosystems
11. Queens researchers reveal parasitic threat to animals and the environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/25/2016)... , Jan. 25, 2016  Glencoe Software, the ... pharma and publication industries, will provide the data management ... Centre (NPSC). ... Phenotypic analysis measures ... whole organisms, allowing comparisons between states such as health ...
(Date:1/21/2016)... , January 21, 2016 ... to a new market research report "Emotion Detection and ... Others), Software Tools (Facial Expression, Voice Recognition and ... - Global forecast to 2020", published by MarketsandMarkets, ... expected to reach USD 22.65 Billion by 2020, ...
(Date:1/20/2016)... Jan. 20, 2016  Synaptics Incorporated (NASDAQ: ... solutions, today announced sampling of S1423, its newest ... and small screen applications including smartwatches, fitness trackers, ... round and rectangular shapes, as well as thick ... with moisture on screen, while wearing gloves, and ...
Breaking Biology News(10 mins):
(Date:2/6/2016)... ... 06, 2016 , ... The Center for Excellence in Education (CEE) will sponsor ... on Wednesday February 10, 2016. This Bite of Science session, hosted by the ... at 1500 Remount Road in Front Royal, VA from 5:00 p.m. to 8:00 p.m. ...
(Date:2/5/2016)... 2016  In the pharmaceutical industry the medical affairs ... launch activities including the identification and engagement of key ... especially high in the oncology therapeutic area where most ... the Role of Medical Affairs in Oncology Launch Excellence ... therapies find better ways to utilize medical affairs to ...
(Date:2/5/2016)... 5, 2016 Australian-US drug discovery and development company, ... appointment of a new Chairman, Mr John O,Connor , ... immediately. James Garner , has also been ... former Acting CEO, Mr Iain Ross , will resume ... --> James Garner , has also been formally appointed ...
(Date:2/4/2016)... , Feb. 4, 2016  Sangamo BioSciences, Inc. ... editing, announced today that Edward Lanphier , Sangamo,s ... on the progress of Sangamo,s ZFP Therapeutic ® ... strategy at 2:40 pm ET on Thursday, February 11, ... Global Healthcare Conference. The conference is being held in ...
Breaking Biology Technology: