Navigation Links
Researchers discover mechanism that limits scar formation
Date:6/10/2010

Researchers from the University of Illinois at Chicago have discovered that an unexpected cellular response plays an important role in breaking down and inhibiting the formation of excess scar tissue in wound healing.

Their study was published online this week in Nature Cell Biology.

When an organism suffers severe injury, specialized cells are "recruited" to the wound site that rapidly produce extracellular matrix proteins such as collagen to provide structural support to the tissue, according to Lester Lau, professor of biochemistry and molecular biology at the UIC College of Medicine and principal investigator in the study.

Joon-Il Jun, a postdoctoral fellow working in Lau's lab and first author of the paper, found that fibroblasts recruited to the site of skin wounds were entering a state of reproductive dormancy, or cell-cycle arrest, called senescence.

This was quite unexpected, Jun said. Until now senescence was believed to occur in cells that suffered DNA damage -- to prevent them from proliferating and, possibly, becoming cancerous.

He discovered that the senescent fibroblasts were making proteins that degraded the extracellular matrix and accelerated the breakdown of collagen. The senescent cells also stopped making collagen.

"The accumulation of senescent cells in the wound has the biological effect of inhibiting the formation of excess scar tissue," Jun said.

Jun also discovered that a protein called CCN1 is responsible for turning on the senescent state in fibroblasts. He was able to show that in mice with a mutated, non-functional form of CCN1, the fibroblasts at the site of a skin wound did not become senescent, and the wound developed excessive scar tissue.

Further, Jun was able to "rescue" the mutated mice by applying CCN1 protein topically to the skin wound, triggering fibroblast senescence and limiting the formation of scar tissue.

The discovery that senescence is a normal wound-healing response in the skin; that senescence in the wound serves an anti-fibrotic function; and that CCN1 is the critical protein that controls this process may prove important in understanding a wide range of pathological conditions related to tissue scarring, said Lau.

"For example, chronic injury to the liver from a number of causes, including viral infections, alcoholism, diabetes and obesity, leads to fibrosis and may progress to cirrhosis," Lau said. "After a heart attack, accumulation of scar tissue in the heart impairs its ability to pump efficiently."

The ability to control the formation of scar tissue, or fibrosis, has important implications for future therapies for treating wound-healing disorders, including organ damage where functional tissue is replaced with scar tissue, Lau said.


'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Related biology news :

1. Researchers identify gene linked to hereditary incontinence
2. UCLA stem cell researchers uncover previously unknown patterns in DNA methylation
3. Lasers help researchers predict birds preferred habitat
4. Researchers find gene linked to birth defects
5. Yale researchers develop test to identify best sperm
6. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
7. UCI researchers create retina from human embryonic stem cells
8. Discovery may lead to safer drinking water, cheaper medicine: Queens University researchers
9. Researchers discover new mechanism for clearing blockages from smallest blood vessels
10. Researchers calculate the greenhouse gas value of ecosystems
11. Queens researchers reveal parasitic threat to animals and the environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access System ... over the next decade to reach approximately $1,580 million by 2025. ... forecasts for all the given segments on global as well as ...
(Date:3/22/2017)... NEW YORK , March 21, 2017 /PRNewswire/ ... Customer Marketing Cloud used by retailers such as ... in its platform — Product Recommendations and Replenishment. Using ... to give more personalized product and replenishment recommendations ... purchases, but also on predictions of customer intent ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... As part ... the series will explore the laboratory testing for DIC in order to illuminate this ... disorder which can occur in hospitalized patients resulting in a high degree of morbidity ...
(Date:4/25/2017)... ... 25, 2017 , ... Covalent Metrology has two ... unit provides high-quality data to clients, both faster and cheaper than competing ... are no price premiums, and customers are welcome to participate in the measurements ...
(Date:4/21/2017)... ... April 21, 2017 , ... Having worked on the design ... is pleased to introduce it to top lab design architects from around the country ... and VP of Industrial Design and Engineering Greg Casey will be at the show, ...
(Date:4/21/2017)... ... April 21, 2017 , ... Frederick ... a range of emerging technology-based businesses, recently earned a $77,518 grant from the ... , Founded in 2004, FITCI is Frederick’s first incubator. A non-profit corporation, FITCI ...
Breaking Biology Technology: