Navigation Links
Researchers discover how vitamin D inhibits inflammation
Date:2/23/2012

oduced high levels of cytokines IL-6 and TNF-α, major actors in the inflammatory response. Cells incubated in 30 ng/ml vitamin D and above showed significantly reduced response to the LPS. The highest levels of inflammatory inhibition occurred at 50 ng/ml.

Through a complex series of experiments, the researchers identified a new location where the vitamin-D receptor appears to bind directly to DNA and activate a gene known as MKP-1. MKP-1 interferes with the inflammatory cascade triggered by LPS, which includes a molecule known as p38, and results in higher levels of IL-6 and TNF-α.

"This newly identified DNA-binding site for the vitamin-D receptor, and the specific pathways inhibited by higher levels of vitamin D provide a plausible mechanism for many of the benefits that have been associated with vitamin D," said Dr. Goleva. 'The fact that we showed a dose-dependent and varying response to levels commonly found in humans also adds weight to the argument for vitamin D's role in immune and inflammatory conditions."


'/>"/>

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Purdue researchers reveal role of protein mutation in Parkinsons disease
2. UVic researchers among presenters at global science conference
3. Researchers develop better control for DNA-based computations
4. Researchers warn nanoparticles in food, vitamins could harm human health
5. Worlds top technology researchers coming to Queens for TEI 2012
6. Researchers make living model of brain tumor
7. MDC researchers reveal molecular mechanism underlying severe anomalies of the forebrain
8. Grass to gas: UGA researchers genome map speeds biofuel development
9. Researchers develop new method for creating tissue engineering scaffolds
10. No entry without protein recycling: RUB researchers discover new coherence in enzyme transport
11. Biodiversity enhances ecosystems global drylands -- Ben-Gurion U researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... FOREST, Calif. , March 3, 2015 ... the leading provider of advanced cryogenic logistics ... markets including immunotherapies, stem cells, cell lines, ... and reproductive medicine, today announced the expansion ... Cancer Research Centers, ("Fred Hutch") Clinical ...
(Date:3/2/2015)... , March 2, 2015   Neurotechnology , a ... introduced the SentiGaze Software Development Kit (SDK). ... applications that use off-the-shelf webcams to track eye movements ... at a monitor. Heatmaps can be used for applications ... of online advertising. The SDK can also be used ...
(Date:2/24/2015)... This report analyzes the worldwide markets for Face and ... and Voice Biometrics. The report provides separate comprehensive analytics for the ... Europe , Asia-Pacific , ... and Latin America . Annual estimates and forecasts ... historic analysis is provided for these markets. Market data and analytics ...
Breaking Biology News(10 mins):Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16
... animals a unique fish that lives on land and can ... and complex social life, a new study has found., The odd ... been detailed for the first time in research findings that throw ... land., The Pacific leaping blenny is a marine fish yet is ...
... could protect crucial habitat for the vast majority of ... according to researchers at Stanford University and the National ... the Aug. 16 edition of the Proceedings of ... 129 species of marine mammals on Earth, including seals, ...
... August 29, 2011 Collaborating researchers at Stanford ... compounds that show promise as potential therapeutics for a ... together of a protein known as transthyretin (TTR). ... TTR protein, work by holding the protein together in ...
Cached Biology News:Landlubber fish leap for love when tide is right 2Preserving 4 percent of the ocean could protect most marine mammal species, study finds 2Preserving 4 percent of the ocean could protect most marine mammal species, study finds 3Scientists find new drug candidates for set of protein-folding diseases 2Scientists find new drug candidates for set of protein-folding diseases 3
(Date:3/4/2015)... March 4, 2015 AcelRx Pharmaceuticals, Inc. ... company focused on the development and commercialization of ... breakthrough pain, today announced that it will release ... market close on Monday, March 9th, 2015. AcelRx ... 4:30 p.m. Eastern Time (1:30 p.m. Pacific Time) ...
(Date:3/4/2015)... March 4, 2015 ... Paris en décembre 2011, l,étude ...   », qui compare   l es ...   sorafénib dans le carcinome hépatocellulaire avancé, a ... du foie avancé   ; les résultats sont ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 Experts and ... schedules for one event: the Alltech REBELation exploring innovation, ... May 17-20. Now in its 31st year, Alltech’s annual ... 70 countries, and the opportunity to join the REBELation ... 7 at 11:59 p.m. EST, at which point the ...
(Date:3/3/2015)... , March 3, 2015 Adaptive Biotechnologies ... CFO, is joining its Board of Director as Chair ... officer at Zillow Group, Chad oversees all finance, treasury ... built the company,s core finance, treasury and accounting functions, ... and nine acquisitions. In 2013, he was named Puget ...
Breaking Biology Technology:AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 2AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 3Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 2Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 3Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 4Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 5Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 6World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 3World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 4Adaptive Biotechnologies adds Chad Cohen, Zillow Group CFO, to Board of Directors 2
... announced that the first patient has received an initial ... first oncology product, MM-121, a,fully human monoclonal antibody and ... receptor., ErbB3 is a receptor in the ErbB ... signaling. With the initiation of the Phase 1 trial, ...
... Aug. 11 /Xinhua-PRNewswire-FirstCall/ -- China,Bionanometer Industries Corporation ... the bionanometer industry, has promoted a new ... thorough period of,scientific verification, research and experiments. ... over six months in the northeast region ...
... at The University of Texas at San Antonio (UTSA) South ... Texas Health Science Center at San Antonio (UTHSCSA) have identified ... the early infectious process against Francisella tularensis, a ... tularemia. The findings will be released this week in a ...
Cached Biology Technology:Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1 Study of MM-121, an ErbB3 Antagonist 2Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1 Study of MM-121, an ErbB3 Antagonist 3China Bionanometer Industries Corporation Promotes New Product 'Beauty Look' in China 2UTSA/UTHSCSA publish results on bio-threat agent 2
... a high-throuput screening of a biological systems ... induced changes in the expression levels of ... detected, studied, classified and compared to each ... at a glance. Automatized scanning of the ...
... agitation and temperature control for microbiology and ... independently and is suitable for DASGIP bioreactors ... volume. Its temperature ranges from approximately 10 ... is equipped with an individual electrical heating ...
... stain is a sensitive nucleic acid gel ... RNA and low background in gels, making it ... gels using laser scanners or standard UV transilluminators. ... unit size (S-7564) and a special packaging (S-7586) ...
Sirtuin 7 (SIRT7) Rabbit anti-Human Polyclonal Antibody Immunogen: Synthetic peptide - KLH conjugated Family: Other Recommended Storage: Long term: -20C; Short term: +4C...
Biology Products: