Navigation Links
Researchers discover how the kissing disease virus hijacks human cells
Date:4/9/2014

This news release is available in French.

University of Montreal researchers have discovered how a component of the Epstein Barr (EBV) virus takes over our cells gene regulating machinery, allowing the virus to replicate itself. The EBV virus causes a variety of diseases such as Hodgkin's lymphoma and Burkitt's lymphoma, with the most prevalent disease being infectious mononucleosis commonly known as "kissing disease" because of its mode of transmission between humans. It turns out that the diseases begin with kiss of a molecular sort; a viral protein contacting the molecules that control our genes.

Viruses such as EBV use sophisticated strategies to subvert human cells during an infection. The viruses cannot survive outside of human cells and for this reason they have developed strategies to mimic key components of human cell function such as the RNA polymerase. "Unraveling the atomic level details of these interactions using structural biology allows us to understand how the virus tricks the human defense systems. Having this knowledge is the first step towards developing new therapeutic treatments for viral infections", explained Dr. James Omichinski, senior author of this work conducted in collaboration with his colleague Dr. Jacques Archambault at the Institut de recherches cliniques de Montral (IRCM).

Using cutting-edge nuclear magnetic resonance techniques at the University of Montreal facility for structural biology in the Department of Biochemistry and Molecular Medicine, the scientists studied how the EBNA2 protein of the EBV virus binds to one of the proteins of the TFIIH complex that helps regulate another protein called RNA polymerase II, a molecule that is responsible for the control of most of our genes. "We were able to unravel the molecular details of the interaction between these proteins", explains Dr. Omichinski.

To unravel the molecular details of this interaction, the lead author Philippe Chabot labeled the EBNA2 protein and TFIIH with stable isotopes and determined the molecular structure of their interaction using NMR spectroscopy. "This type of instrumentation costs several millions dollars, but thanks to generous investments made by the Canada Foundation for Innovation (CFI) we are able to conduct such studies with the most modern equipment", explained Dr. Omichinski. A direct benefit of this work is that the "kissing" interaction between EBNA2 proteins and TFIIH could be a target for drug development to better treat kissing disease and cancers caused by EBV viruses in future.


'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-566-3813
University of Montreal
Source:Eurekalert

Related biology news :

1. Researchers say Neanderthals were no strangers to good parenting
2. UNC researchers show how cancer cells may respond to mechanical force
3. Dartmouth researchers identify potential therapeutic target for deadly brain cancer
4. Researchers find arid areas absorb unexpected amounts of atmospheric carbon
5. Researchers receive $1.14 million to study threats to honey bees
6. Swedish researchers show impact of long-term vitamin D insufficiency on fracture risk
7. Guelph researchers solve part of hagfish slime mystery
8. Researchers design trees that make it easier to produce paper
9. Researchers manipulate tiny objects with ultrasound
10. UCSB researchers create first regional Ocean Health Index
11. Researchers identify how zinc regulates a key enzyme involved in cell death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/14/2016)... , Nov. 14, 2016  Based on ... market, Frost & Sullivan recognizes FST Biometrics ... Award for Visionary Innovation Leadership. FST Biometrics ... biometric identification market by pioneering In Motion ... for instant, seamless, and non-invasive verification. This ...
(Date:6/22/2016)... 2016 On Monday, the Department of Homeland ... share solutions for the Biometric Exit Program. The Request ... Protection (CBP), explains that CBP intends to add biometrics ... the United States , in order to deter ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/15/2016)... York , June 15, 2016 ... new market report titled "Gesture Recognition Market by Application ... Forecast, 2016 - 2024". According to the report, the  ... 11.60 billion in 2015 and is estimated to ... USD 48.56 billion by 2024.  Increasing ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... NORWALK, Conn. , Dec. 2, 2016  The ... research presentations from the MMRF CoMMpass Study SM —the ... and accelerating precision medicine in multiple myeloma—will be presented ... (ASH) Annual Meeting & Exposition in San ... are helping to optimize treatment strategies, as well as ...
(Date:12/2/2016)... Research and Markets has announced the addition of ... to their offering. ... , , An ... is anticipated. Nanotechnology will be applied at all stages of ... applications in clinical trials. Many of the assays based on ...
(Date:12/2/2016)... ... December 01, 2016 , ... Aerocom ... North American hospitals, will present its chain-of-custody solution for tracking and securing medications ... Vegas, Nev., Dec. 4-8, 2016. , Aerocom has a proven solution for tracking ...
(Date:12/2/2016)... ... 2016 , ... DrugDev believes the only way to achieve real ... All three tenets were on display at the 2nd Annual DrugDev User Summit (hosted ... CRO and site organizations to discuss innovation and the future of clinical research. ...
Breaking Biology Technology: