Navigation Links
Researchers discover how the kissing disease virus hijacks human cells
Date:4/9/2014

This news release is available in French.

University of Montreal researchers have discovered how a component of the Epstein Barr (EBV) virus takes over our cells gene regulating machinery, allowing the virus to replicate itself. The EBV virus causes a variety of diseases such as Hodgkin's lymphoma and Burkitt's lymphoma, with the most prevalent disease being infectious mononucleosis commonly known as "kissing disease" because of its mode of transmission between humans. It turns out that the diseases begin with kiss of a molecular sort; a viral protein contacting the molecules that control our genes.

Viruses such as EBV use sophisticated strategies to subvert human cells during an infection. The viruses cannot survive outside of human cells and for this reason they have developed strategies to mimic key components of human cell function such as the RNA polymerase. "Unraveling the atomic level details of these interactions using structural biology allows us to understand how the virus tricks the human defense systems. Having this knowledge is the first step towards developing new therapeutic treatments for viral infections", explained Dr. James Omichinski, senior author of this work conducted in collaboration with his colleague Dr. Jacques Archambault at the Institut de recherches cliniques de Montral (IRCM).

Using cutting-edge nuclear magnetic resonance techniques at the University of Montreal facility for structural biology in the Department of Biochemistry and Molecular Medicine, the scientists studied how the EBNA2 protein of the EBV virus binds to one of the proteins of the TFIIH complex that helps regulate another protein called RNA polymerase II, a molecule that is responsible for the control of most of our genes. "We were able to unravel the molecular detail
'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-566-3813
University of Montreal
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers say Neanderthals were no strangers to good parenting
2. UNC researchers show how cancer cells may respond to mechanical force
3. Dartmouth researchers identify potential therapeutic target for deadly brain cancer
4. Researchers find arid areas absorb unexpected amounts of atmospheric carbon
5. Researchers receive $1.14 million to study threats to honey bees
6. Swedish researchers show impact of long-term vitamin D insufficiency on fracture risk
7. Guelph researchers solve part of hagfish slime mystery
8. Researchers design trees that make it easier to produce paper
9. Researchers manipulate tiny objects with ultrasound
10. UCSB researchers create first regional Ocean Health Index
11. Researchers identify how zinc regulates a key enzyme involved in cell death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ... today announced sampling of ClearPad ® 4300, ... (TDDI) product targeting smartphones and tablets. This new ... , best-in-class touch controller IP and systems ... in the company,s Japan Design Center. TDDI enables ...
(Date:7/9/2015)... DUBLIN , July 07, 2015 ... has announced the addition of the "Biometrics ... and Forecasts 2015-2020" report to their offering. ... a major contributor to this growth and the ... US$5.5 billion in revenue for companies involved in ...
(Date:7/8/2015)... NEW YORK , July 8, 2015 ... cancer globally, and the fourth most fatal, with a ... year. The poor prognosis of pancreatic cancer patients has ... to treatment, which is not being met by the ... contains an array of products with varying molecule types ...
Breaking Biology News(10 mins):Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3
... airborne-laser technology, and ground-based plot surveys, scientists from ... colleagues from the World Wildlife Fund and in ... (MINAM), have revealed the first high-resolution maps of ... emitted by land-use practices. These new maps pave ...
... September 6 issue of the Journal of Cell Biology ( ... protein, CEP290. The results could be applied toward targeted gene ... CEP290 cause cilia-related disorders that range in severity from isolated ... Meckel syndrome, Joubert syndrome, and NPHPthe most common syndromic form ...
... projects in Human Genetics has been launched today: Epitwin ... differences between 5,000 twins on a scale and depth ... development of drug treatments. The project is ... based at King,s College London, and BGI, one of ...
Cached Biology News:Carbon mapping breakthrough 2Carbon mapping breakthrough 3Largest ever epigenetics project launched 2
(Date:7/29/2015)... ... July 29, 2015 , ... Brady (NYSE:BRC), ... GHS Label Guide . To align chemical container labeling with OSHA’s updated Hazard ... of label components, an example of an accurate label, and pictogram uses and ...
(Date:7/29/2015)...  Therapath Neuropathology ( www.Therapath.com ), a leader ... and Military Medical centers both domestically and worldwide.  ... Sweat Gland Nerve Fiber Density (SGNFD) for the ... Demonstration of a reduction in ... skin biopsy is a highly sensitive and specific ...
(Date:7/29/2015)... -- Indivior PLC (LON: INDV) today announced that the New ... and received Priority Review by the U.S. Food and ... This naloxone nasal spray comes as a pre-filled device ... the nasal mucosa. 1 The device has been ... better equipped to help an opioid overdose victim. ...
(Date:7/29/2015)... - RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSX.V: RP), ... announce that the final design specifications of its ... for industrial and regulatory testing will now be ... mark clearance to market the injector in ... (Photo: http://photos.prnewswire.com/prnh/20150729/248373 )  The RCI-02 ...
Breaking Biology Technology:Brady Announces a New GHS Label Guide 2Neuropathology services for VA and Military health systems 2Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 2Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 3Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 4Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 5RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 3RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 4RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 5
... fight against neglected tropical diseasesWASHINGTON, April 22 ... as members of Congress, the African Diplomatic Corps and ... a delegation of senior African health officials to Washington, ... delegation presented a tribute to President Jimmy Carter and ...
... to sustainabilityLAS VEGAS, April 22 Bayer CropScience ... tomorrow today through its sustainability efforts. Today, John ... CropScience, presented Tom Lovelace, United Fresh Produce Association ... the next four years to create the Center ...
... 22 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (TSX: AEZ; ... company focused on endocrine therapy and oncology, today ... its orally-active tubulin and topoisomerase II inhibitor compound, ... lymphoma, which may potentially provide a new therapeutic ...
Cached Biology Technology:African Health Delegates Welcomed to Washington 2Bayer CropScience Donates $1.1 Million to United Fresh Research & Education Foundation to Create the Center for Global Produce Sustainability 2Bayer CropScience Donates $1.1 Million to United Fresh Research & Education Foundation to Create the Center for Global Produce Sustainability 3Bayer CropScience Donates $1.1 Million to United Fresh Research & Education Foundation to Create the Center for Global Produce Sustainability 4AEterna Zentaris Presents Phase 1 Results for AEZS-112 in Patients with Advanced Cancer and Lymphoma at AACR Annual Meeting in Denver 2AEterna Zentaris Presents Phase 1 Results for AEZS-112 in Patients with Advanced Cancer and Lymphoma at AACR Annual Meeting in Denver 3
Immunogen: Recombinant full length protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
... Immunogen: Synthetic peptide derived from ... and bovine Math-2. Specificity: Specific ... Human Rat (positive controls: human U251 ... lysates and rat brain homogenates)Storage: Store ...
...
Biology Products: