Navigation Links
Researchers discover how heart arrhythmia occurs
Date:1/19/2014

Researchers have discovered the fundamental biology of calcium waves in relation to heart arrhythmias.

The findings published this month in the January 19 edition of Nature Medicine outlines the discovery of this fundamental physiological process that researchers hope will one day help design molecularly tailored medications that correct the pathophysiology.

Heart arrhythmias cause the heart to beat irregularly, resulting in symptoms such as dizziness and fainting, or in severe cases, sudden arrhythmic death. While many factors contribute to the development of arrhythmias, including genetics, scientists know that a common mechanism of cardiac arrhythmias is calcium overload in the heart, i.e. calcium-triggered arrhythmias that can lead to sudden death. The underlying mechanism of these calcium-triggered arrhythmias has remained a mystery for decades.

Using a combination of molecular biology, electrophysiology, and genetically engineering mice, scientists at the University of Calgary's and Alberta Health Services' Libin Cardiovascular Institute of Alberta (Libin Institute)have discovered that a calcium-sensing-gate in the cardiac calcium release channel (ryanodine receptor) is responsible for initiation of calcium waves and calcium-triggered arrhythmias.

Utilizing a genetically modified mouse model they were able to manipulate the sensor and completely prevented calcium-triggered arrhythmias.

"The calcium-sensing- gate mechanism discovered here is an entirely novel concept with potential to shift our general understanding of ion channel gating, cardiac arrhythmogenesis, and the treatment of calcium-triggered arrhythmias," says SR Wayne Chen, PhD, the study's senior author and University of Calgary- Libin Institute researcher. "These findings open a new chapter of calcium signaling and the discovery fosters the possibilities of new drug interventions."


'/>"/>
Contact: Marta Cyperli
mcyperli@ucalgary.ca
403-210-3835
University of Calgary
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers collaborate to reduce effects of the aging eye
2. 1 step at a time, researchers learning how humans walk
3. Researchers discover that coevolution between humans and bacteria reduces gastric cancer risk
4. Researchers identify key components linking circadian rhythms and cell division cycles
5. Microbes swap for tiny goods in minuscule markets, researchers find
6. New discovery could stimulate plant growth and increase crop yields, researchers say
7. White House lauds ONR-funded researchers for early success
8. KIT researchers develop artificial bone marrow
9. Researchers pursuing arthritis protein
10. Researchers discover a tumor suppressor gene in a very aggressive lung cancer
11. Researchers unveil rich world of fish biofluorescence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2015)... This report provides market analysis of the ... It contains an analysis of the drivers, challenges, and ... from the short, medium, and long term perspective landscapes. ... and technology trends that currently, prevail in the market. ... to efficiently manage the increasing marine traffic and increasing ...
(Date:6/24/2015)... Research and Markets( ... "Huawei Ascend Mate 7 Fingerprint Sensor - ... Huawei,s technological choice for the fingerprint ... Apple,s and Samsung,s one. The Ascend Mate 7 ... Cards, a main actor in capacitive sensing human ...
(Date:6/23/2015)... Minn. , June 23, 2015   ... company that supports the entire spectrum of clinical ... iMedNet ™ , the company,s intuitive, ... been awarded a Silver 2015 Stevie® Award by ... Health Products & Services Website category.  The American ...
Breaking Biology News(10 mins):Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2
... second generation biofuels made from inedible plant material, ... and numerous scientific studies have shown them to ... our transportation needs. However, before we can begin ... grassoline, numerous barriers must be overcome, starting with ...
... has pledged $50,000 to fund the work of University ... who are working to develop a computer program that ... Wii video game console. Students James McKee, Jack ... the project as seniors at UAB. Along with faculty ...
... A new unique work published by Springer, the ... the influence of complexity and system science to a ... In eleven volumes, available in print and electronically, ... applying the concepts of complexity theory together with the ...
Cached Biology News:New technique can fast-track better ionic liquids for biomass pre-treatments 2New technique can fast-track better ionic liquids for biomass pre-treatments 3New technique can fast-track better ionic liquids for biomass pre-treatments 4UAB students' Nintendo Wii CPR earns American Heart Association support 2A complete view of complexity in science and society in a new authoritative reference work 2
(Date:7/1/2015)... Indianapolis, IN (PRWEB) , ... July 01, 2015 , ... ... the 2015 BIO International Convention in Philadelphia, PA. , The presentation took ... milestones and outlined the plans for the development of APX3330 for the treatment of ...
(Date:6/30/2015)... ... 2015 , ... Students and faculty from Beijing City University ... “Integrative Biotechnology,” an applied biotechnology course team-taught by faculty members from both institutions. ... from both universities and is taught on both continents. , “Our alliance with ...
(Date:6/30/2015)... -- Juniper Pharmaceuticals, Inc. (Nasdaq: JNP ), a specialty ... unmet medical needs in women,s health, today announced ... at the Cantor Fitzgerald Inaugural Healthcare Conference as ... PM EDTLocation: , Le Parker Meridien Hotel, New ... under  ,Investor, or  click here The ...
(Date:6/30/2015)... ... June 30, 2015 , ... Noblis, ... government, announced in a paper published this week in the scientific journal Viruses ... the diagnostic techniques currently used to detect the Ebola virus. Noblis worked with ...
Breaking Biology Technology:Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2Rivier University and Beijing City University Academic and Cultural Exchanges Begin 2Juniper Pharmaceuticals to Present at Cantor Fitzgerald Inaugural Healthcare Conference on July 8, 2015 2Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 2Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 3Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 4
... , , , , Introduction ... , , , , , ... is an important part of your application. Many variables must be considered, , ... evaporation, and accessory chiller—so it's no surprise to find more , ...
... , , , Katherine A. Borkovich ... University of Texas-Houston Medical Center, , , ... Kimberly Vollmer, Brinkmann™ Instruments Inc., BioSystems Application , ... , , , INTRODUCTION: , ...
... , , , , ... due to a hypoosmolar buffer system and short pulses in the s-range. , ... of sample resistance (patent pending)., , , ... , Two cell lines (mouse fibroblast cells, human T-lymphocytes) ...
Cached Biology Technology:Optimizing Büchi® Rotary Evaporator Applications 2Optimizing Büchi® Rotary Evaporator Applications 3Optimizing Büchi® Rotary Evaporator Applications 4Optimizing Büchi® Rotary Evaporator Applications 5Optimizing Büchi® Rotary Evaporator Applications 6Optimizing Büchi® Rotary Evaporator Applications 7Optimizing Büchi® Rotary Evaporator Applications 8Efficient Transfection of Neurospora Crassa 2Efficient Transfection of Neurospora Crassa 3Efficient Transfection of Neurospora Crassa 4Efficient Transfection of Neurospora Crassa 5
...
p21 Ras Immunogen: Recombinant C-H-ras p21(val-12). Storage: 4 C...
Rabbit polyclonal to Myosin VIIa (rating: *****) ( Abpromise for all tested applications). entrezGeneID: 4647 SwissProtID: Q13402...
Rabbit polyclonal to GPCR G2A ( Abpromise for all tested applications). entrezGeneID: 29933 SwissProtID: Q9UNW8...
Biology Products: