Navigation Links
Researchers discover how heart arrhythmia occurs
Date:1/19/2014

Researchers have discovered the fundamental biology of calcium waves in relation to heart arrhythmias.

The findings published this month in the January 19 edition of Nature Medicine outlines the discovery of this fundamental physiological process that researchers hope will one day help design molecularly tailored medications that correct the pathophysiology.

Heart arrhythmias cause the heart to beat irregularly, resulting in symptoms such as dizziness and fainting, or in severe cases, sudden arrhythmic death. While many factors contribute to the development of arrhythmias, including genetics, scientists know that a common mechanism of cardiac arrhythmias is calcium overload in the heart, i.e. calcium-triggered arrhythmias that can lead to sudden death. The underlying mechanism of these calcium-triggered arrhythmias has remained a mystery for decades.

Using a combination of molecular biology, electrophysiology, and genetically engineering mice, scientists at the University of Calgary's and Alberta Health Services' Libin Cardiovascular Institute of Alberta (Libin Institute)have discovered that a calcium-sensing-gate in the cardiac calcium release channel (ryanodine receptor) is responsible for initiation of calcium waves and calcium-triggered arrhythmias.

Utilizing a genetically modified mouse model they were able to manipulate the sensor and completely prevented calcium-triggered arrhythmias.

"The calcium-sensing- gate mechanism discovered here is an entirely novel concept with potential to shift our general understanding of ion channel gating, cardiac arrhythmogenesis, and the treatment of calcium-triggered arrhythmias," says SR Wayne Chen, PhD, the study's senior author and University of Calgary- Libin Institute researcher. "These findings open a new chapter of calcium signaling and the discovery fosters the possibilities of new drug interventions."


'/>"/>
Contact: Marta Cyperli
mcyperli@ucalgary.ca
403-210-3835
University of Calgary
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers collaborate to reduce effects of the aging eye
2. 1 step at a time, researchers learning how humans walk
3. Researchers discover that coevolution between humans and bacteria reduces gastric cancer risk
4. Researchers identify key components linking circadian rhythms and cell division cycles
5. Microbes swap for tiny goods in minuscule markets, researchers find
6. New discovery could stimulate plant growth and increase crop yields, researchers say
7. White House lauds ONR-funded researchers for early success
8. KIT researchers develop artificial bone marrow
9. Researchers pursuing arthritis protein
10. Researchers discover a tumor suppressor gene in a very aggressive lung cancer
11. Researchers unveil rich world of fish biofluorescence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... May 23, 2017  Hunova, the first robotic gym for the rehabilitation ... officially launched in Genoa, Italy . The first 30 ... and the USA . The technology was developed and ... by the IIT spin-off Movendo Technology thanks to a 10 million euro ... Release, please click: ...
(Date:5/16/2017)... 2017  Veratad Technologies, LLC ( www.veratad.com ), an ... identity verification solutions, announced today they will participate as ... 15 thru May 17, 2017, in Washington ... Center. Identity impacts the lives of ... quickly evolving digital world, defining identity is critical to ...
(Date:5/16/2017)... May 16, 2017   Bridge Patient Portal ... and MD EMR Systems , an electronic ... for GE, have established a partnership to build ... and the GE Centricity™ products, including Centricity Practice ... These new integrations will allow healthcare ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... ... 25, 2017 , ... Activate Healthcare, a leading provider of ... fastest growing private companies, has selected Twine for its Employee Health Activation Platform. ... transformative model that empowers deep collaboration and behavior change. In randomized controlled trials, ...
(Date:5/26/2017)... ... May 25, 2017 , ... Throughout this ... studies, describing how process development and economic goals were achieved in both industry ... a hollow-fiber bioreactor system, along with techniques for scaling production of mesenchymal stem ...
(Date:5/26/2017)... ... May 25, 2017 , ... Studying biological events ... occurrence. Live cell imaging using fluorescence microscopy is the perfect approach to explore ... microscopy methods will be discussed, from small animal models and tissues to individual ...
(Date:5/26/2017)... ... May 25, 2017 , ... LabRoots , the leading provider ... from around the world, is announcing a new textbook scholarship, the second scholarship in ... graduate students, 17 years or older, pursuing a degree in one of the life ...
Breaking Biology Technology: