Navigation Links
Researchers discover genetic link between immune system, Parkinson's disease
Date:8/15/2010

But the system doesn't always work perfectly. HLA genes are highly variable from individual to individual. Certain variants of the genes are associated with increased risk or protection against infectious disease, while other variants can induce autoimmune disorders in which the immune system attacks the body's own tissues. Multiple sclerosis, a neurological disease caused by autoimmunity, is also associated with HLA-DR. The genetic variant that is associated with Parkinson's disease is in the same region as the one associated with multiple sclerosis.

People who take non-steroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen) have a reduced risk of developing Parkinson's disease, which also supports an immune-related mechanism. The protective effect of NSAIDs is not the same for everyone, likely because of genetic differences, and NSAIDs can have side effects. Pursuing the connection between Parkinson's disease and inflammation, especially in the context of variable genetic makeup, may lead to better, more selective drugs for treating Parkinson's disease.

Consortium leaders recognize the study would not have been possible without the precious help from volunteer patients. "This type of research could not be done if it weren't for the willing and dedicated individuals who volunteer as research subjects," said Payami, who acknowledged that some study subjects participated for nearly two decades.

What's next for the team? "Our results also pointed to several other genes that might play a role in developing Parkinson's disease, and these findings need to be confirmed, so we have a lot of work ahead of us" said Zabetian. He and others in the consortium will now mine the data even more for gene-environment interactions, with a goal of finding environmental triggers and protectors to develop genetically-personalized therapeutics for treatment and prevention of Parkinson's disease.


'/>"/>

Contact: Mary Guiden
mguiden@uw.edu
206-616-3192
University of Washington
Source:Eurekalert

Page: 1 2

Related biology news :

1. Ben-Gurion U. researchers receive US-AID MERC grant for water project with the Palestinian authority
2. Illinois researchers use pyrosequencing to study canine intestinal bacteria
3. Researchers find that one type of stem cell creates a niche for another type in bone marrow
4. VIB and UGent researchers identify key mechanisms of cell division in plants
5. Rutgers researchers assess severity of prostate cancers using magnetic resonance imaging
6. Carnegie Mellon researchers turn up brightness on fluorescent probes
7. Researchers demonstrate highly directional terahertz laser rays
8. Hebrew University researchers identify gene related to chronic pain
9. UC Riverside researchers measure diesel emissions on the freeway
10. Windy cities: Researchers invent new tool to calculate hurricane risk
11. NSF funds Virginia Tech program to train researchers at intersection of engineering, biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... stark warning on the possible effects of gases such ... times that of carbon dioxide. Now a team of ... fully regenerable electron acceptors which helps explain why large ... being released to the atmosphere. However, there are worries ... into a vicious cycle to release large amounts of ...
(Date:4/17/2014)... genetic information of DNA is used to manufacture ... different functions in living organisms. Messenger RNA (mRNA) ... by relating the genetic information of DNA to ... , By examining the different types and amounts ... a given time, researchers can determine which specific ...
(Date:4/17/2014)... a new way the immune system may fight cancers ... use immune cells to treat illness. , The research, ... equivalent of "neighborhood police" specialized squads of defenders ... of an entire city, the body. , Scientists at ... shown that the liver, skin and uterus each has ...
Breaking Biology News(10 mins):Methane climate change risk suggested by proof of redox cycling of humic substances 2Rapid and accurate mRNA detection in plant tissues 2Some immune cells defend only 1 organ 2
... Georgia researchers are working to understand why the nation,s ... northern California,s Sacramento-San Joaquin Bay Delta, an environmentally endangered ... Doug Peterson and Robert Bringolf, both with the UGA ... work on the one-year, $200,000 joint project funded by ...
... now watch molecules move in living cells, literally millisecond ... scientists at the European Molecular Biology Laboratory (EMBL) in ... , the new technique provides insights into processes that ... and single molecule spectroscopy, the new microscope can record ...
... one-quarter of male scientists at the nation,s top research universities ... children as they had wanted, according to a new study ... The study, "Scientists Want More Children," was authored by sociologists ... and appears in the current issue of the journal ...
Cached Biology News:UGA researchers study threats to white sturgeon 2UGA researchers study threats to white sturgeon 3Live from the scene: Biochemistry in action 2Many top US scientists wish they had more children 2Many top US scientists wish they had more children 3
(Date:1/15/2014)... This webinar will focus on EMA ... assessment in biosimilars. , Regulatory frameworks are evolving many ... however the complex nature of biopharmaceuticals makes the demonstration ... extremely challenging. Based on the specific aspects of biosimilar ...
(Date:1/15/2014)... 2014 More than 5 million Americans ... in 3 seniors will die with Alzheimer’s or another ... figures have shocked many Americans into looking for ways ... these tragic age-related cognitive disorders. Jonathan Weisman, president of ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how latent ... viruses is the Epstein Barr Virus (EBV), and one of ... a chronic inflammatory disease that destroys the body’s joints. As ... have high concentrations of EBV DNA in their bodies (1). ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 2013 was ... Scottsdale’s Brain State Technologies®. They saw continued independent research ... Center who were awarded a $1 million grant from ... in “Brain and Behavior” a peer reviewed journal, Amy ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... Management Form Company ... Podiatry Markets, FAIRFIELD, N.J., May 13 Medimetriks ... led by the founder and the key Senior Management ... will develop, license and,commercialize innovative prescription products for the ...
... 13 /PRNewswire-FirstCall/ - AEterna Zentaris Inc.,(NASDAQ: ... company focused on,endocrine therapy and oncology, today ... 2 study of subcutaneously,administered LHRH antagonist cetrorelix ... has been accepted for publication in an,upcoming ...
... SAN DIEGO and TUCSON, Ariz., May 12 ,University-affiliated ... creating opportunities for sustainable development and,innovation within economies ... in La Jolla on June 16 to share ... maximizing the effectiveness of parks,specializing in biotechnology development., ...
Cached Biology Technology:Medimetriks Pharmaceuticals, Inc. Begins Operations 2AEterna Zentaris: Article on Phase 2 Trial with Cetrorelix in BPH to be Published in European Urology Journal 2AEterna Zentaris: Article on Phase 2 Trial with Cetrorelix in BPH to be Published in European Urology Journal 3AEterna Zentaris: Article on Phase 2 Trial with Cetrorelix in BPH to be Published in European Urology Journal 4AEterna Zentaris: Article on Phase 2 Trial with Cetrorelix in BPH to be Published in European Urology Journal 5AEterna Zentaris: Article on Phase 2 Trial with Cetrorelix in BPH to be Published in European Urology Journal 6University Research and Science Parks Create Sustainable Innovation 2
...
...
...
... Sepharose High Performance, 5 ml. The ... in HiTrap Streptavidin columns for fast, ... packing into Tricorn 5/50 GL, XK ... scale purifications are required.Extremely useful for ...
Biology Products: