Navigation Links
Researchers discover genetic link between immune system, Parkinson's disease
Date:8/15/2010

A team of researchers has discovered new evidence that Parkinson's disease may have an infectious or autoimmune origin. "Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease" appears online in Nature Genetics.

The study was conducted by the NeuroGenetics Research Consortium, an international team of researchers led by Haydeh Payami, research scientist at the New York State Department of Health Wadsworth Center. The clinical directors for the study were Dr. Cyrus Zabetian, associate professor of neurology at the University of Washington and VA Puget Sound Health Care System, Stewart Factor at Emory University and John Nutt at Oregon Health and Sciences University.

The research team studied more than 2,000 Parkinson's disease patients and 2,000 healthy volunteers from clinics in Oregon, Washington, New York and Georgia, assessing clinical, genetic and environmental factors that might contribute to the development and progression of Parkinson's disease and its complications. Some of the research subjects were tracked for nearly two decades.

"Over the years, there have been subtle hints that immune function might be linked to Parkinson's disease" said Zabetian. "But now we have much more convincing evidence of this and a better idea of which parts of the immune system might be involved."

In the study, researchers detected a new association with the HLA (human leukocyte antigen) region, which contains a large number of genes related to immune system function in humans. With the new findings, and link to HLA, researchers will now be encouraged to take a fresh look at the possible role of infections, inflammation and autoimmunity in Parkinson's disease.

HLA genes are essential for recognizing foreign invaders from the body's own tissues. Similarly, HLA molecules are supposed to recognize a body's own tissue as itself and prevent immune reactions against them.
'/>"/>

Contact: Mary Guiden
mguiden@uw.edu
206-616-3192
University of Washington
Source:Eurekalert

Page: 1 2

Related biology news :

1. Ben-Gurion U. researchers receive US-AID MERC grant for water project with the Palestinian authority
2. Illinois researchers use pyrosequencing to study canine intestinal bacteria
3. Researchers find that one type of stem cell creates a niche for another type in bone marrow
4. VIB and UGent researchers identify key mechanisms of cell division in plants
5. Rutgers researchers assess severity of prostate cancers using magnetic resonance imaging
6. Carnegie Mellon researchers turn up brightness on fluorescent probes
7. Researchers demonstrate highly directional terahertz laser rays
8. Hebrew University researchers identify gene related to chronic pain
9. UC Riverside researchers measure diesel emissions on the freeway
10. Windy cities: Researchers invent new tool to calculate hurricane risk
11. NSF funds Virginia Tech program to train researchers at intersection of engineering, biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... stress-related psychiatric disorders are associated with increased ... mechanisms underlying this relation are unknown. Understanding ... of targeted preventive strategies and new or ... work is presented at the European College ... international group of researchers from Germany and ...
(Date:10/17/2014)... – Accurate knowledge regarding Ebola is critical and pertinent ... of hazardous global outbreak and epidemic. The Journal, ... a special issue, Ebola Virus and Public Health, to ... knowledge in this critical societal moment. , On ... Ebola for Clinicians . The primer was prepared by ...
(Date:10/17/2014)... is available in German . ... very few drugs. When treating overdoses, doctors are often limited ... difficult if there is a combination of drugs involved. So ... accidentally swallows his grandmother,s pills? ETH professor Jean-Christophe Leroux from ... find an answer to this question. "The task was to ...
Breaking Biology News(10 mins):Researchers find why depression and aging linked to increased disease risk 2Emergency aid for overdoses 2Emergency aid for overdoses 3
... Evergreen State College currently advises a team of ... prison-issued garb rather than the lab coats and ... team composed of such apparently iconoclastic researchers? Because ... Creek Corrections Center, a medium security prison in ...
... Reducing the number of deer in forests and ... and insects in that area, new research suggests. ... University and National Park Service found that higher deer ... of several species of snakes, salamanders, and invertebrates studied, ...
... 2008 -- The widespread use of pesticides across the United ... of the long-term effects on the nation,s groundwater. ... taken from over 300 wells across the US have not ... a result of a decadal long study to assess the ...
Cached Biology News:Inmates conduct ecological research on slow-growing mosses 2Snakes, salamanders and other creatures thrive in areas with higher deer populations 2Snakes, salamanders and other creatures thrive in areas with higher deer populations 3Pesticide concentrations decreasing 2
(Date:10/19/2014)... The Asian Automatic patient billing report defines ... forecast of revenue. The Automatic patient billing market in ... by 2018, at a developing CAGR of 7.2% from ... the Asian Automatic patient billing market, to get an ... a glimpse of the segmentation of this market in ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The report ... Market Share, Trade, Prices, Geography Trend and Forecast (2011 ... sales category, and geography and studies the major market ... North America, Europe, and Asia. , The global chocolate ... 2010.to $98.3 billion in 2016 at an estimated CAGR ...
(Date:10/19/2014)... October 19, 2014 The report ... & Homeland Security), Technology, Payload, Type & by ... segments the global unmanned ground vehicle market into ... forecasting of market sizes. The report also identifies ... opportunities impacting it along with the adoption trends. ...
(Date:10/18/2014)... The “Human Insulin Market- by Product Type, [Human ... Insulin (Rapid Acting, Long Acting, Premixed)], by Brand ... Forecast to 2018” provides a detailed overview of ... trends, and strategies impacting the global human insulin ... the revenue and share analysis. , The global ...
Breaking Biology Technology:The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5
... KUNMING, China, Feb. 7 /Xinhua-PRNewswire/ -- China ... (Amex:,KUN), which is engaged in the research, ... and cosmetic products,in the People,s Republic of ... its 12Ways(R) Skin Care products in the ...
... (Nasdaq:,DNDN) today announced that Mitchell H. Gold, M.D., chairman ... update at the 10th,Annual BIO CEO & Investor Conference ... 1:15 p.m. ET., A live audio webcast of ... of the Dendreon website, http://www.dendreon.com . If you are ...
... ROCKVILLE, Md. and MONROVIA, Calif., Feb. 7 ,Human ... Xencor, Inc. today announced,a collaboration agreement under which ... technologies to enhance the,pharmacologic properties of monoclonal antibodies ... HGS., (Logo: http://www.newscom.com/cgi-bin/prnh/20010612/HGSLOGO ), ...
Cached Biology Technology:China Shenghuo to Market 12Ways(R) Skin Care Products in the U.S. through Agreement with Home Shopping Group 2China Shenghuo to Market 12Ways(R) Skin Care Products in the U.S. through Agreement with Home Shopping Group 3Human Genome Sciences and Xencor Announce Antibody Collaboration 2Human Genome Sciences and Xencor Announce Antibody Collaboration 3Human Genome Sciences and Xencor Announce Antibody Collaboration 4
...
... bioinformatics software that has changed the way ... design of BioNumerics allows for integration and ... data employed for the characterization of organisms ... protein gels, HPLC, VNTR, MLST, SNP, fatty ...
Request Info...
Cultrex 3D Culture Matrix Rat Collagen I....
Biology Products: