Navigation Links
Researchers discover genetic differences between lethal and treatable forms of leukemia
Date:1/7/2010

l role in determining the responsiveness of the disease to therapy," says Dr. Melnick.

Traditionally, AML patients are treated with first-line chemotherapy drugs. If they fail, patients are classified as having a more severe and difficult-to-treat disease, and are then given a more aggressive therapy, like a bone marrow transplant. Being able to tell which patients are most likely to fail standard treatments could lead to the administration of more precise therapies at the outset of treatment.

They also concluded that a set of 15-gene DNA methylation biomarker was highly predictive of overall patient survival. "The findings have the potential to tell physicians whether or not a patient has a relatively easy or difficult disease to treat, and tailor a patient's therapy accordingly," explains Dr. Melnick. "This saves time trying therapies that will eventually prove to have no effect."

In addition, the investigators discovered a set of 45 genes that are almost universally methylated in AML patients. Methylation of these genes was far more common than any genetic mutation associated with AML, and could provide new ways to more effectively therapeutically target AML in the future.

"Investigators from the Sackler Center at Weill Cornell are leaders in the field of decoding epigenetic information from human tumors and ascertaining their clinical impact," says Dr. Andrew I. Schafer, chairman of the Department of Medicine at NewYork-Presbyterian Hospital/Weill Cornell Medical College. "Such findings will lead to the development of new therapies that give hope to cancer patients who are now without effective treatment."


'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2

Related biology news :

1. U of Alberta researchers find mechanism that could prevent or treat deadly peroxisome diseases
2. Researchers pin down long-elusive protein thats essential to life as we know it
3. Researchers use new acoustic tools to study marine mammals and fish
4. Researchers to investigate the genetics of congenital heart disease
5. Researchers design a tool to induce controlled suicide in human cells
6. Researchers work on vaccine to improve immune system in newborns
7. IUPUI researchers tackle protein mechanisms behind limb regeneration
8. MDC researchers identify a scaffold regulating protein disposal
9. UCLA researchers engineer bacteria to turn carbon dioxide into liquid fuel
10. Berkeley Lab researchers participate in Homeland Security study of subway airflow
11. Hebrew University, American researchers show trigger to stem cell differentiation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... -- Research and Markets has announced the ... Industry Analysis Size Share Growth Trends and Forecast to ... http://photos.prnewswire.com/prnh/20130307/600769 The rising number ... for high level security in both private and public ... username and passwords, tokens etc. are vulnerable to attacks. ...
(Date:7/11/2014)... de Janeiro, Brazil- In the brains of all ... that allows an electric or chemical signal to ... Chemical synapses, which are the most abundant type ... Synapse formation is crucial for learning, memory, perception ... inhibitory synapses critical for brain function. For ...
(Date:7/10/2014)... , June 27, 2014  The American Academy ... Institute of Standards and Technology (NIST) and the ... academic research and forensic science expert members to ... is an element of the NIST,s Organization of ... among the first appointments made to the new ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2Blame it on the astrocytes 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3
... reduces spoilage explains a scientist at the Society for ... explains how ozone treatment could be a safe, effective ... foods. It is estimated that up to 30% ... spoilage. Dr Singleton from Newcastle University explains that low ...
... being able to develop a computer model of the brain ... functions of nerve cells in the brain together for the ... in the neuroscience known as ,connectomics,. With parallels to genomics, ... the brain,s connections (known as ,synapses,). By mapping these connections ...
... Lee, a graduate student in Cornell University,s Dyson School of ... known as "the halo effect" for some time. Psychologists have ... of a person can be influenced by how we perceive ... the fact that a person has a positive attribute can ...
Cached Biology News:Ozone reduces fungal spoilage of fruits and vegetables 2Mapping the brain: New technique poised to untangle the complexity of the brain 2Mapping the brain: New technique poised to untangle the complexity of the brain 3The health halo effect: Don't judge a food by its organic label 2
(Date:7/10/2014)... OMICS Group’s 5th International conference and ... 2014 at Double Tree by Hilton Beijing, China is ... Analytical & Bioanalytical research methods only to facilitate improved ... occasion, Dr. Srinubabu Gedela, MD of OMICS Group Inc ... remarkable one in bringing a unique and international mix ...
(Date:7/10/2014)... POINT, Ind. , July 10, 2014 ... expanded its use of capnography for respiratory ... growing group of healthcare leaders in embracing ... measures how effectively patients are breathing and ... depression occurs. By measuring the amount of ...
(Date:7/10/2014)... Utah , July 10, 2014 /PRNewswire-iReach/ ... annotation and interpretation, today announced an agreement ... (NGS) analytics for Lineagen,s NextStep Dx ... of neurodevelopmental and neurological disorders, currently offers ... microarray (CMA) testing service used by healthcare ...
(Date:7/10/2014)... to the International Atomic Energy Agency (IAEA) the ... acquiring sufficient quantities of plutonium or highly enriched ... device. The IAEA also notes that most cases ... which can be challenging to detect with most ... appearing this week in the Journal of ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Sensitive detection method may help impede illicit nuclear trafficking 2
... , DURHAM, N.C., Nov. 27 Cromoz ... nanotube-based cancer drug delivery system in Hyderabad, India. The water-soluble ... allows for conjugation with cancer drugs, was developed in partnership ... nanotubes serves as a drug delivery vehicle with the ability ...
... of ultrasmall transistors and more powerful computer chips using ... after a key discovery by researchers at IBM, Purdue ... The researchers have learned how to create nanowires ... at the atomic level, which is a critical requirement ...
... ... of Canada , ... (Vocus) November 25, 2009 -- Ambassador to Speak at Economic Club of Canada., , , ... Invest in France Agency ,To view a biography of David Appia go to www.investinfrance.org ...
Cached Biology Technology:North Carolina Based Cromoz Inc. Launches Carbon Nanotechnology for Target Drug Delivery System in Cancer Treatment in Hyderabad, India 2Nanowires key to future transistors, electronics 2Nanowires key to future transistors, electronics 3French Ambassador for International Investment to Visit Toronto December 11 2
... Provides up to 30 minutes of walkaway time. Automatic Calibration. Five minute cooldown ... port. ... ... ...
Vybrant® Multidrug Resistance Assay Kit...
...
... culture systems provide an integrated set-up ... and imaging. Each system uses medical-grade ... coverslips in cell culture plates. The ... ready to use. Individual chambered coverslips ...
Biology Products: