Navigation Links
Researchers discover gene that causes obesity in mice

AURORA, Colo. (March 5, 2013) Researchers have discovered that deleting a specific gene in mice prevents them from becoming obese even on a high fat diet, a finding they believe may be replicated in humans.

"When fed a diet that induces obesity these mice don't get fat," said Prof. James McManaman, Ph.D., lead author of the study and vice-chairman of research for Obstetrics and Gynecology at the University of Colorado School of Medicine. "It may be possible to duplicate this in humans using existing technology that targets this specific gene."

The two-year study, funded by the National Institutes of Health and the U.S. Department of Agriculture, was published last month in the Journal of Lipid Research.

The research team created a strain of mice without the Plin2 gene which produces a protein that regulates fat storage and metabolism. They immediately found that the mice were resistant to obesity.

Usually, mice fed a high fat diet will eat voraciously, yet these showed an unusual restraint. Not only did they eat less, they were more active.

Their fat cells were also 20 percent smaller than typical mice and did not show the kind of inflammation usually associated with obesity, the study said. Obesity-associated fatty liver disease, common in obese humans and rodents, was absent in the mice without the Plin2 gene.

"The mice were healthier," McManaman said. "They had lower triglyceride levels, they were more insulin-sensitive, they had no incidents of fatty liver disease and there was less inflammation in the fat cells."

The absence of the gene may cause fat to be metabolized faster, he said.

"Now we want to know why this works physiologically," McManaman said. "We want to better understand how this affects food consumption."

According to the study, understanding how Plin2 is involved in the control of energy balance will provide new insights into "the mechanisms by which n

Contact: David Kelly
University of Colorado Denver

Page: 1 2

Related biology news :

1. U of M researchers utilize genetically corrected stem cells to spark muscle regeneration
2. Researchers id queens, mysterious disease syndrome as key factors in bee colony deaths
3. Study led by NUS researchers proves the existence of 3 overstretched DNA structures
4. U of M researchers identify genetic variation behind acute myeloid leukemia treatment success
5. 3 Johns Hopkins researchers recognized for medical inventions
6. University of Alberta researchers bake a better loaf of bread
7. Researchers at IRB Barcelona discover a general mechanism that accelerates tumor development
8. Brown University researchers build robotic bat wing
9. Researchers say sunlight yields more efficient carbon dioxide to methanol model
10. Researchers decipher modus operandi of potential Alzheimers drug
11. Stanford researchers develop tool for reading the minds of mice
Post Your Comments:
(Date:9/28/2015)... According to a new market ... (Scanner & Others), Application (Access Control & Others), Industry ... Geography Global - Forecast to 2020", published by MarketsandMarkets, the ... Million by 2020, at a CAGR of 23.40% between ... data T ables and 66 Figures ...
(Date:9/10/2015)... 10, 2015 This report provides detailed descriptions ... today, and emerging sensor types that will dominate in ... peak of the wearable technology hype curve in the ... The common feature with all of them is the ... their most useful functions. Sensors collect data about the ...
(Date:9/9/2015)... Sept. 9, 2015  NuData Security announced today ... milestones, furthering the company,s commitment to protecting organizations ... NuData Security,s online fraud detection solution, ... growth cycle. The product combines continual analysis and ... user behavior from fraudulent behavior, allowing the company ...
Breaking Biology News(10 mins):Iris Recognition Market 3627.90 Million USD by 2020 2Iris Recognition Market 3627.90 Million USD by 2020 3Iris Recognition Market 3627.90 Million USD by 2020 4Wearable Sensors 2015-2025: Market Forecasts, Technologies, Players 2NuData Security Achieves Significant Milestones, Furthers Commitment to Providing Unparalleled Online Fraud Detection 2
... discovered that a group of remarkable ancient sea creatures ... sizes than previously thought, thanks to extraordinarily well-preserved fossils ... were already thought to be the largest animals of ... saw the sudden appearance of all the major animal ...
... Northwest has the diverse feedstocks, fuel-delivery infrastructure and ... industry capable of reducing greenhouse gases and meeting ... Creating an aviation biofuels industry, however, will depend ... the aviation industry in U.S. biofuel development. , ...
... malaria, TB & HIV/AIDS cause more than five million deaths ... of Washington and represent one of the world,s major ... of the 21st century. In the May 26, 2011, edition ... Director Alan Aderem, Ph.D., along with Rino Rappuoli, Ph.D., Global ...
Cached Biology News:Scientists discover fossil of giant ancient sea predator 2Study details path to sustainable aviation biofuels industry in Northwest 2Study details path to sustainable aviation biofuels industry in Northwest 32020 vision of vaccines for malaria, TB and HIV/AIDS 2
(Date:10/1/2015)... 1, 2015 Oramed Pharmaceuticals Inc. ... pharmaceutical company focused on the development of oral drug ... in the upcoming Aegis Growth Conference, taking place October ...  Josh Hexter, COO of Oramed, will present a corporate ... Details:   2015 Aegis Growth Conference ...
(Date:10/1/2015)... ... ... of Radiant Hearth in Potsdam, NY. and a member of the Masonry Heater Association ... family in northern New York. The masonry heater fireplace is beautiful, simple, and it burns ... to keep the home comfortable but when it is below zero, their needs to be ...
(Date:9/30/2015)... Resverlogix Corp. (the "Corporation") (TSX:RVX) today announced that, at its ... 2015, each of the five nominees proposed as a director ... 2015 were elected as directors.  Proxy voting results for each ... % For , % WithheldDonald J. McCaffrey , 32,978,486 ... 0.40% Peter Johann , 32,990,226 , ...
(Date:9/30/2015)... 30, 2015  Berg, a Boston ... today announced it will join an industry collaboration with ... Cameron , Genomics England is partnering with innovative health ... 100,000 human genomes and create a new genomic medicine ... The project focuses on patients with rare diseases and ...
Breaking Biology Technology:Oramed to Present at the Aegis Capital Growth Conference 2Oramed to Present at the Aegis Capital Growth Conference 3The Masonry Heater Association of North America Receives News About A New York Couple Who Saved Considerable Money Heating Their Home With A Wood Fired Masonry Heater 2Resverlogix Announces Voting Results 2Berg Joins U.K. Prime Minister's Initiative, Genomics England to Sequence 100,000 Genomes 2Berg Joins U.K. Prime Minister's Initiative, Genomics England to Sequence 100,000 Genomes 3
... de France s fourth stage Wednesday, Lance Armstrong and the U.S. ... the designers at Trek Bicycles happy: they made the ... Wisconsin, the now-international company has provided U.S. Postal with bicycles from ... help lead to a sixth consecutive victory for the team. , ...
... Hospital of Wisconsin is helping to heal heart ... tissue causing the abnormality. , ,A special catheter made ... low as minus 80 degrees Celsius inside the beating ... electrophysiologist and pediatric cardiologist guide the catheter through a ...
... protecting businesses , ,MADISON, Wis. NameProtect ... MasterCard to help battle online identity theft and ... the arrangement, NameProtect will use its technology to identify ... of payment fraud. Phishing describes the act of an ...
Cached Biology Technology:Armstrongs new Trek modeled on AMD 64-bit processors 2NameProtect and MasterCard unite to combat online fraud, phishing 2
Rabbit Anti-Ferret Whole Serum Antibody, Unconjugated...
... CTI Molecular Imaging's proprietary Focus™ detector technology, ... as the R4. The microPET Focus ... commerically avaiable PET scanner. Focus scanners ... any scinitallor based PETsystems. The combination ...
... pAcGHLT-A,B,C Baculovirus ... Set,pAcGHLT-XylE Baculovirus ... Powder,Thrombin Dilution ... Cocktail,Insect Cell ...
... This product has been developed to significantly ... labeled proteins. Stability is increased at ... 2-8 centigrade. This product is subjected ... mercury or azide. This formulation insures ...
Biology Products: