Navigation Links
Researchers discover gene mutations that cause childhood brain cancer
Date:3/8/2009

March 8, 2009 TORONTO Researchers funded by the Canadian Cancer Society have discovered eight similar genes that, when mutated, appear to be responsible for medulloblastoma the most common of childhood brain cancers. The findings are published today in the online edition of the journal Nature Genetics.

"This discovery is very promising and may help researchers develop better, more targeted treatments so that more of these children will survive and fewer will suffer debilitating side effects," says Dr. Christine Williams, Director of Research Programs, Canadian Cancer Society Research Institute.

Dr. Michael Taylor, who has a $600,000 research grant from the Canadian Cancer Society, led the study: "When these eight genes are functioning normally, we believe their role is to make a protein which tells the developing brain when it's time to stop growing. But when the genes are mutated, the brain may continue to grow out of control, leading to cancer.

"Drugs are already being developed that target these types of proteins," he says. "Our hope is that some of these drugs may be adapted and used effectively to treat medulloblastomas." Dr. Taylor is a pediatric brain surgeon at Toronto's Hospital for Sick Children:

In the study, the largest of its kind, researchers looked at more than 200 tumour samples. The samples came from children in countries all over the world including Canada, the US, England, Poland and Saudi Arabia. Paul Northcott, a PhD student in Dr Taylor's lab, analyzed and interpreted all the data over a period of 3 years. "We've learned more from this study about the genetic basis of this disease than from any other previous study," Northcott says. The gene mutations they found had not been suspected as culprits in cancer formation.

About 250 Canadian children are diagnosed with various types of brain cancer every year. About 70 per cent of these survive. Brain tumours are the leading cause of childhood cancer deaths. The most common childhood brain cancer is medulloblastoma a tumour that occurs at the back of the brain in the cerebellum. It is primarily a disease of very young children and is particularly deadly among babies under 18 months of age. In Canada, about 40 children are diagnosed with medulloblastoma every year and half of these will survive.

Many survivors experience serious physical and neurological problems from the disease itself and from the effects of very aggressive treatments on the developing brain. Treatments include surgery, radiation and chemotherapy.


'/>"/>

Contact: Christine Harminc
charminc@cancer.ca
416-934-5650
Canadian Cancer Society
Source:Eurekalert

Related biology news :

1. Pitt researchers describe molecular 2-step leading to protein clumps of Huntingtons disease
2. Climate change affecting Europes birds now, say researchers
3. CSHL researchers pinpoint structure-building role for 2 non-coding RNAs
4. Ben-Gurion University of the Negev researchers develop new reversible, green window technology
5. Two UT Southwestern researchers awarded Sloan fellowships
6. 2 McGill researchers garner prestigious NSERC Steacie Fellowships
7. Texas Obesity Research Center at UH assembles researchers to discuss obesity
8. U-M researchers ID gene involved in pancreatic cancer
9. USC researchers identify gene variant associated with both autism and gastrointestinal dysfunction
10. Researchers piggyback to safer reprogrammed stem cells
11. Researchers capture wave of brain activity linked to anticipation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/21/2016)... VANCOUVER, British Columbia , June 21, 2016 ... been appointed to the new role of principal ... has been named the director of customer development. ... , NuData,s chief technical officer. The moves reflect ... development teams in response to high customer demand ...
(Date:6/9/2016)... -- Perkotek an innovation leader in attendance control systems is proud to announce the introduction ... to make sure the right employees are actually signing in, and to even control ... ... ... ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) ... million US Dollar project, for the , Supply ... Enrolment, and IT Infrastructure , to ... implementation of Identity Management Solutions. Numerous renowned international vendors participated ... was selected for the most compliant and innovative ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016   Boston ... of novel compounds designed to target cancer stemness ... has been granted Orphan Drug Designation from the ... treatment of gastric cancer, including gastroesophageal junction (GEJ) ... inhibitor designed to inhibit cancer stemness pathways by ...
(Date:6/23/2016)... 2016  The Prostate Cancer Foundation (PCF) is pleased to announce ... cures for prostate cancer. Members of the Class of 2016 were selected from ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published ... how a patient who developed lymphedema after being treated for breast cancer benefitted from ... the paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... Francisco, CA (PRWEB) , ... June 23, 2016 ... ... (EDC) software, is exhibiting at the Pennsylvania Convention Center and will showcase its ... Annual conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical ...
Breaking Biology Technology: