Navigation Links
Researchers discover 'gateway' in nucleus has a second important job no one noticed before
Date:3/7/2013

UAlberta medical researchers and their American colleagues have discovered that the "gateway" known to control the movement of molecules in and out of a cell's nucleus appears to play another critically important role one no one had noticed until now.

These "gateways" have a second key job in a cell the ability to control the structure of chromosomes and the DNA linked to those chromosomes. This impacts what genes produce or express. The discovery gives scientists a new way to investigate the triggers for various kinds of disease, says Richard Wozniak, the principal investigator with the Faculty of Medicine & Dentistry, who worked on the discovery with collaborators from the Institute for Systems Biology (Seattle).

"This discovery may explain links between disease and defects in these gateways," he says.

"Our studies provide new insights into how the nucleus is organized and how the genetic material it houses is used, including important information about the jobs genes do. When cells have to adapt to their environment, they need to change their gene expressions pattern. If this isn't done right, diseases such as cancer or heart disease occur. Our work also provides insight into why many viral infections target this gateway for their survival."

The research team's discovery was recently published in the peer-reviewed journal, Cell.

Wozniak and his team are continuing their research in this area. They want to learn more about this new mechanism when it functions properly, and what causes it to malfunction. Uncovering the key players in this new mechanism are also key, he says.

"We want to understand how these gateways are functioning at a molecular level what makes them capable of altering the structure of chromosomes and making other key changes? That is our next step," says Wozniak, who is a researcher with the Department of Cell Biology.


'/>"/>

Contact: Raquel Maurier
raquel.maurier@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers explain a key developmental mechanism for the first time in plants
2. Researchers find molecular switch turning on self-renewal of liver damage
3. UGA researchers shed light on ancient origin of life
4. Researchers discover workings of brains GPS system
5. Researchers propose new solution to ensure biofuel plants dont become noxious weeds
6. Temple researchers discover key to heart failure, new therapies on horizon
7. Researchers discover gene that causes obesity in mice
8. U of M researchers utilize genetically corrected stem cells to spark muscle regeneration
9. Researchers id queens, mysterious disease syndrome as key factors in bee colony deaths
10. Study led by NUS researchers proves the existence of 3 overstretched DNA structures
11. U of M researchers identify genetic variation behind acute myeloid leukemia treatment success
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... MELBOURNE, Florida , April 11, 2017 ... "Company"), a security technology company, announces the appointment of independent ... John Bendheim to its Board of Directors, furthering the ... ... behalf of NXT-ID, we look forward to their guidance and ...
(Date:4/5/2017)... , April 5, 2017 Today ... announcing that the server component of the HYPR platform ... for providing the end-to-end security architecture that empowers biometric ... HYPR has already secured over 15 million users ... including manufacturers of connected home product suites and physical ...
(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... ... April 20, 2017 , ... ... unique intellectual property (IP) sharing and commercialization model. , The Center for Advancing ... main component of this effort is bringing the IP to the attention of ...
(Date:4/20/2017)... and PETACH TIKVAH, Israel , April ... leading developer of adult stem cell technologies for neurodegenerative diseases, ... will present at the Alliance for Regenerative Medicine,s (ARM) 5 ... Thursday, April 27, 2017 at 09:40 EDT in ... Kern , MD, MHSc, Chief Medical Officer & Chief Operating ...
(Date:4/19/2017)... ... April 18, 2017 , ... The Vibrating Orifice Aerosol Generator ... generating monodisperse droplets of known diameters for research applications such as for calibrating ... by drying monodisperse droplets. , The VOAG requires forcing liquid out of ...
(Date:4/19/2017)... ... April 18, 2017 , ... Alisa Wright, founder and CEO of Singota ... College of Pharmacy in Lafayette, Indiana. , The Distinguished Alumni Award was established ... careers and other scientific endeavors. , Wright began her career in the pharmaceutical ...
Breaking Biology Technology: