Navigation Links
Researchers discover 'gateway' in nucleus has a second important job no one noticed before
Date:3/7/2013

UAlberta medical researchers and their American colleagues have discovered that the "gateway" known to control the movement of molecules in and out of a cell's nucleus appears to play another critically important role one no one had noticed until now.

These "gateways" have a second key job in a cell the ability to control the structure of chromosomes and the DNA linked to those chromosomes. This impacts what genes produce or express. The discovery gives scientists a new way to investigate the triggers for various kinds of disease, says Richard Wozniak, the principal investigator with the Faculty of Medicine & Dentistry, who worked on the discovery with collaborators from the Institute for Systems Biology (Seattle).

"This discovery may explain links between disease and defects in these gateways," he says.

"Our studies provide new insights into how the nucleus is organized and how the genetic material it houses is used, including important information about the jobs genes do. When cells have to adapt to their environment, they need to change their gene expressions pattern. If this isn't done right, diseases such as cancer or heart disease occur. Our work also provides insight into why many viral infections target this gateway for their survival."

The research team's discovery was recently published in the peer-reviewed journal, Cell.

Wozniak and his team are continuing their research in this area. They want to learn more about this new mechanism when it functions properly, and what causes it to malfunction. Uncovering the key players in this new mechanism are also key, he says.

"We want to understand how these gateways are functioning at a molecular level what makes them capable of altering the structure of chromosomes and making other key changes? That is our next step," says Wozniak, who is a researcher with the Department of Cell Biology.


'/>"/>

Contact: Raquel Maurier
raquel.maurier@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers explain a key developmental mechanism for the first time in plants
2. Researchers find molecular switch turning on self-renewal of liver damage
3. UGA researchers shed light on ancient origin of life
4. Researchers discover workings of brains GPS system
5. Researchers propose new solution to ensure biofuel plants dont become noxious weeds
6. Temple researchers discover key to heart failure, new therapies on horizon
7. Researchers discover gene that causes obesity in mice
8. U of M researchers utilize genetically corrected stem cells to spark muscle regeneration
9. Researchers id queens, mysterious disease syndrome as key factors in bee colony deaths
10. Study led by NUS researchers proves the existence of 3 overstretched DNA structures
11. U of M researchers identify genetic variation behind acute myeloid leukemia treatment success
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/7/2016)... June 7, 2016  Syngrafii Inc. and San ... relationship that includes integrating Syngrafii,s patented LongPen™ eSignature ... This collaboration will result in greater convenience for ... union, while maintaining existing document workflow and compliance ... ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) ... million US Dollar project, for the , Supply ... Enrolment, and IT Infrastructure , to ... implementation of Identity Management Solutions. Numerous renowned international vendors participated ... was selected for the most compliant and innovative ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, Biometrics & ... & Other Service  The latest report from ... of the global Border Security market . Visiongain ... billion in 2016. Now: In November 2015 ... and hardware technologies for advanced video surveillance. ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... medical technologies, services and solutions to the healthcare market. The company's primary focus ... distribution, manufacturing, sales and marketing strategies that are necessary to help companies efficiently ...
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... discussions on a range of subjects including policies, debt and ... Poloz. Speaking at a lecture to the Canadian ... to the country,s inflation target, which is set by both ... "In certain areas there needs to be ... why not sit down and address strategy together?" ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers ... the 6000i models are higher end machines that use the more unconventional z-dimension of ... beam from the bottom of the cuvette holder. , FireflySci has developed several ...
Breaking Biology Technology: