Navigation Links
Researchers discover 'gateway' in nucleus has a second important job no one noticed before
Date:3/7/2013

UAlberta medical researchers and their American colleagues have discovered that the "gateway" known to control the movement of molecules in and out of a cell's nucleus appears to play another critically important role one no one had noticed until now.

These "gateways" have a second key job in a cell the ability to control the structure of chromosomes and the DNA linked to those chromosomes. This impacts what genes produce or express. The discovery gives scientists a new way to investigate the triggers for various kinds of disease, says Richard Wozniak, the principal investigator with the Faculty of Medicine & Dentistry, who worked on the discovery with collaborators from the Institute for Systems Biology (Seattle).

"This discovery may explain links between disease and defects in these gateways," he says.

"Our studies provide new insights into how the nucleus is organized and how the genetic material it houses is used, including important information about the jobs genes do. When cells have to adapt to their environment, they need to change their gene expressions pattern. If this isn't done right, diseases such as cancer or heart disease occur. Our work also provides insight into why many viral infections target this gateway for their survival."

The research team's discovery was recently published in the peer-reviewed journal, Cell.

Wozniak and his team are continuing their research in this area. They want to learn more about this new mechanism when it functions properly, and what causes it to malfunction. Uncovering the key players in this new mechanism are also key, he says.

"We want to understand how these gateways are functioning at a molecular level what makes them capable of altering the structure of chromosomes and making other key changes? That is our next step," says Wozniak, who is a researcher with the Department of Cell Biology.


'/>"/>

Contact: Raquel Maurier
raquel.maurier@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers explain a key developmental mechanism for the first time in plants
2. Researchers find molecular switch turning on self-renewal of liver damage
3. UGA researchers shed light on ancient origin of life
4. Researchers discover workings of brains GPS system
5. Researchers propose new solution to ensure biofuel plants dont become noxious weeds
6. Temple researchers discover key to heart failure, new therapies on horizon
7. Researchers discover gene that causes obesity in mice
8. U of M researchers utilize genetically corrected stem cells to spark muscle regeneration
9. Researchers id queens, mysterious disease syndrome as key factors in bee colony deaths
10. Study led by NUS researchers proves the existence of 3 overstretched DNA structures
11. U of M researchers identify genetic variation behind acute myeloid leukemia treatment success
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2017)...  The general public,s help is being enlisted in what,s thought to ... and on the human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest ... the gut. The project's goal is to help advance scientific knowledge of ... ...
(Date:6/30/2017)... 30, 2017 Today, American Trucking Associations ... of face and eye tracking software, became the ... program. "Artificial intelligence and advanced ... monitor a driver,s attentiveness levels while on the ... to detect fatigue and prevent potential accidents, which ...
(Date:5/23/2017)...  Hunova, the first robotic gym for the rehabilitation and functional motor ... Genoa, Italy . The first 30 robots will be ... USA . The technology was developed and patented at the ... spin-off Movendo Technology thanks to a 10 million euro investment from entrepreneur ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... A new study published ... frozen and fresh in vitro fertilization (IVF) transfer cycles. The multi-center ... success. , After comparing the results from the fresh and frozen transfer cohorts, ...
(Date:10/10/2017)... Philadelphia, PA (PRWEB) , ... October 10, 2017 ... ... University City Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. ... accept the award for Excellence in Volunteer Experience from US2020. , US2020’s mission ...
(Date:10/10/2017)... SANTA BARBARA, CALIFORNIA (PRWEB) , ... October 10, ... ... risk management, technological innovation and business process optimization firm for the life sciences ... the BoxWorks conference in San Francisco. , The presentation, “Automating GxP ...
(Date:10/9/2017)... ... ... At its national board meeting in North Carolina, ARCS® Foundation ... Physics and Astronomy, has been selected for membership in ARCS Alumni Hall of ... Breakthrough Prize in Fundamental physics for the discovery of the accelerating expansion of the ...
Breaking Biology Technology: