Navigation Links
Researchers discover critical detail of cellular defense against genetic mistakes
Date:4/17/2008

steady-state rounds then direct the mass production of normal proteins based on NMD-approved mRNAs. Over time, the Maquat lab, along with other labs, has identified a number of protein complexes that form during the intricate process by which cells analyze each mRNA for flaws.

In the past, her team showed, for instance, which proteins bind to each end of mRNA during the pioneer and subsequent steady-state rounds of translation, and how the pioneer round, cap-binding protein promotes the recognition and decay of flawed mRNAs. The team also demonstrated how other complexes that identify flawed mRNAs form near exon-exon junctions, the places where each must read section of the mature mRNA template is joined to the next by RNA splicing.

Past work by Maquats team further revealed that much of the NMD quality review depends on the physical spacing of proteins bound to the mRNA chain. If a stop reading signal occurs too far ahead of the final exon in the chain, as marked by an exon-exon junction complex (EJC), the cell concludes that the stop codon has mistakenly fallen in the middle of a set of instructions. These mRNAs are degraded. They also found that the EJC contains human up-frameshift (UPF) proteins that play a role in NMD.

In their latest search for detail, Maquat and colleagues determined that the delivery of a given faulty mRNA to the degradation machinery requires first the active shutdown (translational repression) of protein building based on that mRNA. In the studys key finding, experiments revealed that repression of protein synthesis during NMD is controlled the attachment of phosphate groups to human UPF1, researchers said. Human cells have evolved such that phosphorylation, the attachment of phosphate groups to proteins, is used in many scenarios like a switch to turn processes on or off.

Based on their findings, Maquat and colleagues propose the following new model for NMD: When a nonsense stop codon is detected,
'/>"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... molecules, which have similar counterparts in humans, affect the ... nerve signals into the hippocampus, an area of the ... and the creation of memories. The results of the ... . , Brain function depends on the active communication ... neurons are woven together into a dense network where ...
(Date:7/24/2014)... For years, researchers and patients have hoped that ... type in the bodycould provide insight into numerous diseases ... has been hampered by the inability to transfer research ... counterparts, in part because human ESCs are "primed" and ... Thorold Theunissen, Benjamin Powell, and Haoyi Wang, who are ...
(Date:7/24/2014)... of researchers led by the University of York has ... in the Western Indian Ocean. , The results, ... to a revolution in the management of marine protected ... than 11,000 km in the region now under ... zones of the seas and coasts designed to protect ...
Breaking Biology News(10 mins):A protein couple controls flow of information into the brain's memory center 2A protein couple controls flow of information into the brain's memory center 3A protein couple controls flow of information into the brain's memory center 4Whitehead Institute researchers create 'naïve' pluripotent human embryonic stem cells 2Western Indian Ocean communities play vital role in conservation 2
... nation that stretches from coast to coast to coast. But ... climate change? Yves Glinas, associate professor in Concordia,s Department of ... element: iron. In a study published in Nature ... and graduate Alexandre Ouellet, as well as McGill colleague Alfonso ...
... 14, 2012 The latest episode in the American ... podcast series describes the development of a new test ... Amid concerns about the threat of terrorist attacks, ... and other nations. One such team has developed a ...
... March 14, 2012 UC Irvine researchers have discovered how ... that causes major gastrointestinal distress in humans, thrives in the ... it. Their findings help explain why Salmonella ... possible treatments. Most people infected with Salmonella suffer ...
Cached Biology News:Fielding questions about climate change 2New test could help track down and prosecute terrorists 2UCI-led study uncovers how Salmonella avoids the body's immune response 2
(Date:7/24/2014)... , July 24, 2014 Research and ... "Global Cell Culture Market 2014-2018" report to their ... Cell culture is the in vitro growth of ... research, cell studies, and biopharmaceutical production. Cell culture is ... Cell culture instruments and cell culture consumables are necessary ...
(Date:7/24/2014)... 24, 2014 SRI International has been awarded ... Institute of Allergy and Infectious Diseases (NIAID), part of ... of potential therapies for HIV infection and AIDS. The ... and AIDS and the complications and opportunistic infections associated ... sexual transmission of HIV. According to ...
(Date:7/24/2014)... 2014 Deep Research Report on Global ... and in-depth research report on Potassium Sulphate ... information, including its definition, classification, application, and industry ... the international market analysis, including China’s domestic market ... environment & economic situation analysis, the influence of ...
(Date:7/24/2014)... balances – 4 steps – One Recommendation: the web-based ... narrows down the mass of product choices to a ... , First, select the working environment, then enter the ... define the accuracy – it’s really that simple. Specifying ... to models that fit best with the customer’s industry ...
Breaking Biology Technology:Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4
... Clarient, Inc.,(Nasdaq: CLRT ), a premier anatomic ... and the pharmaceutical industry,today announced that, effective June ... join Clarient as Senior Vice President and Chief,Financial ... experience as a public,company CFO in life sciences ...
... 28 Sequenom, Inc. (Nasdaq:,SQNM) today announced that a live audio ... investor briefing event,"Sequenom: The Future of Noninvasive Prenatal Diagnostics." Details of ... Sequenom: The Future of Noninvasive Prenatal Diagnostics, When: ... time, Where: http://www.sequenom.com , Agenda: ...
... 28 SoluLinK, Inc., a leader in,next-generation ... announce the,introduction of a new product, NanoLink(TM) ... highest biotin-binding,capacity of any commercially available polymer-encapsulated ... for high throughput robotic applications where high ...
Cached Biology Technology:Clarient Names Raymond J. Land Senior Vice President and Chief Financial Officer 2Clarient Names Raymond J. Land Senior Vice President and Chief Financial Officer 3Clarient Names Raymond J. Land Senior Vice President and Chief Financial Officer 4Clarient Names Raymond J. Land Senior Vice President and Chief Financial Officer 5Sequenom to Webcast Analyst and Investor Briefing Presentation on June 3 2SoluLinK Introduces NanoLink(TM) Streptavidin Magnetic Microspheres 2