Navigation Links
Researchers discover critical detail of cellular defense against genetic mistakes
Date:4/17/2008

Researchers are closing in on a completed diagram of how human cells protect themselves against constant genetic mistakes that contribute to most diseases, according to a study to be published in the April 18 edition of the journal Cell.

The blueprint for the human body is encoded in genes. Gene expression is the process by which those blueprints are converted into proteins that make up the bodys structures and send its signals. When molecular biologists began analyzing the complete set of human genes (the human genome) in 2001, one surprise was that humans have as few as 30,000 genes when, given their complexity, they should have more than 100,000. How can humans have one-fifth as much genetic material as wheat, for instance, or share one quarter of their genes with fish?

One answer is that humans do more with fewer genes. While genes consist of chains of deoxyribonucleic acids (DNA), they are put into practice by chains of ribonucleic acid chains (RNA), which are modified copies of DNA. Messenger RNA (mRNA) is transported to cellular factories called ribosomes that receive instructions for building proteins by reading mRNA templates, a process called translation. Remarkably, about 75 percent of human genes code for more than one protein through a process called alternate RNA splicing. Unfortunately, the more intricate the splicing process, the greater the opportunity for error. More than one-third of alternatively spliced mRNAs are flawed, and must be destroyed before they can cause harm. Thus, cellular processes that detect and eliminate processing errors are vitally important to effective gene expression.

In recent years, researchers at the University of Rochester Medical Center have revealed the existence of a natural surveillance system called nonsense-mediated mRNA decay (NMD) that determines which mRNAs are fit to serve as protein templates and sees to the destruction of those with flaws. Researchers hope to tweak the proc
'/>"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2014)... growing in importance for both basic researchers and ... the University of Maryland have developed a new ... gene activity from RNA sequencing (RNA-seq) data., With ... speedy fish, estimates of gene expression that previously ... few minutes, with accuracy that equals or exceeds ...
(Date:4/20/2014)... corn crop residue to make ethanol and other biofuels ... than gasoline, according to a study published today in ... findings by a University of Nebraska-Lincoln team of researchers ... to meet federal mandates to ramp up ethanol production ... the stalks, leaves and cobs in cornfields after harvest ...
(Date:4/18/2014)... the past 20 years, researchers have published soil organic ... have suggested that soil organic carbon can be sequestered ... to no-till systems. However, there is a growing body ... and soybean rotations without cover crops, small grains, and ... at the published rates. , "Some studies have shown ...
Breaking Biology News(10 mins):Computational method dramatically speeds up estimates of gene expression 2Study casts doubt on climate benefit of biofuels from corn residue 2Study casts doubt on climate benefit of biofuels from corn residue 3Researchers question published no-till soil organic carbon sequestration rates 2Researchers question published no-till soil organic carbon sequestration rates 3Researchers question published no-till soil organic carbon sequestration rates 4
... Carnegie Mellon University,s M. Granger Morgan will unveil a ... can help society reduce dangerous greenhouse gas emissions and ... 9 at 1 p.m. at 1200 New York Ave. ... heads a team of investigators from Carnegie Mellon, the ...
... Philadelphia, PA As children transition from preschool-age to ... that may not meet current recommendations and may contribute ... January/February 2009 issue of the Journal of Nutrition ... that their pre-school children (2 to 5 years) had ...
... in the brain,s hippocampus, but what controls this birth has ... Science , neuroscientists at the Johns Hopkins University School ... which depends on brain activity, also depends on a protein ... genetic material. "How is it that when you ...
Cached Biology News:Carnegie Mellon to unveil new sequestration plan 2Eating habits and exercise behaviors in children can deteriorate early 2Growth of new brain cells requires 'epigenetic' switch 2
(Date:1/15/2014)... A study has been launched to test whether technology ... help to tackle the problem of obesity.  This unique healthcare ... based in Stowmarket) and academics at University Campus Suffolk is ... which is inspired by equipment used to collect data about ...
(Date:1/15/2014)... 2014 DTS Language Services, Inc . ... Portal for Life Science organizations who need document translations. ... matter of their documents in advance with a selection of ... of translations, often a critical factor in clinical and scientific ...
(Date:1/15/2014)... , Jan. 15, 2014 TaiGen Biotechnology Company, Limited ... agreement with R-Pharm, a leading Russian pharmaceutical company, to ... Russian Federation , Turkey ... States (CIS). Nemonoxacin is a novel antibiotic for the treatment ...
(Date:1/14/2014)... Communications, a leading provider of strategic communications services to corporations and ... the United States and Europe ... JD, is returning to the firm,s Washington, D.C. ... more than two years of service as Associate Commissioner for the ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Former FDA Associate Commissioner Returns To 3D Communications 2
... are the words of the automated announcement that one used ... whenever the doors opened. The gap refers to the space ... through the American workplace today, I cant help thinking that ... the country. In this case, the gap to watch out ...
... The Milwaukee Brewers will soon have ... players at Miller Park, officials announced Thursday. , ,Eastman ... will provide a Directview CR 850 computer-operated ... will be used to generate high-resolution digital X-rays of ...
... award from Raj Veeramani, director of the E-Business Institute. ... is a brave new world of advertising, says Jerry Shereshewsky, ... University of Wisconsin student (and cohort of former Madison Mayor ... his impact on the future of business. He was a ...
Cached Biology Technology:Minding the Generation Gap 2Minding the Generation Gap 3Advertising ambassador explains the reinvention of marketing 2Advertising ambassador explains the reinvention of marketing 3
anti-dansyl, rabbit IgG fraction *1 mg/mL* Secondary Detection; Anti-Dye and Anti-Hapten Antibodies...
MOUSE ANTI RAT RT1Ac Immunogen: PHA activated rat lymphocytes...
Prepared in 0.85% saline....
TACS Apoptotic DNA Laddering Kits are used to assay cells and tissues for apoptosis by...
Biology Products: