Navigation Links
Researchers discover a tumor suppressor gene in a very aggressive lung cancer
Date:1/9/2014

In addition to identifying the tumor suppressor role of MAX in lung cancer, the group led by Montse Sanchez-Cespedes has unveiled a functional relationship between MAX and another tumor suppressor, BRG1, in virtue of which BRG1 regulates the expression of MAX through direct recruitment to the MAX promoter. However, the functional connection is even more complex. On one hand, the presence of BRG1 is required to activate neuroendocrine transcriptional programs and to up-regulate MYC-targets, such as glycolytic-related genes. Moreover, the depletion of BRG1 strongly hinders cell growth, specifically in MAX-deficient cells, heralding a synthetic lethal interaction. The preferential toxicity of the inactivation of BRG1 in MAX-deficient lung cancer cells opens novel therapeutic possibilities for the treatment of SCLC patients with MAX-deficient tumors.

The Genes and Cancer group has identified several genes altered in lung cancer. Among these is BRG1 (also called SMARCA4) and the latest generation-sequencing technologies have extended these findings to other tumor types evidencing that BRG1 inactivation is widespread in cancer. BRG1 encodes one ATPase of the SWI/SNF chromatin remodeling complex and Dr. Sanchez-Cespedes group had previously shown that loss of BRG1 is closely related to the activation of MYC in lung cancer. Both conditions are mutually exclusive and act preventing cell differentiation and promoting cell growth. The current discovery that MAX acts as a tumor suppressor in lung cancer provides evidence that an aberrant SWI/SNF-MYC/MAX network is essential for lung cancer development.


'/>"/>
Contact: Arantxa Mena
amena@idibell.cat
34-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert  

Page: 1

Related biology news :

1. Researchers unveil rich world of fish biofluorescence
2. Researchers propose alternative way to allocate science funding
3. New organization brings together top researchers to sequence the genomes of invertebrates
4. Plan to delist gray wolf endangers other threatened species, researchers find
5. Researchers say fructose does not impact emerging indicator for cardiovascular disease
6. Researchers complete a milestone in defining the genetic basis of rheumatoid arthritis
7. Researchers create largest evolutionary timetree of land plants to investigate traits that permit survival in cold climates
8. Penn researchers grow liquid crystal flowers that can be used as lenses
9. UT Southwestern neuroscience researchers identify gene involved in response to cocaine
10. ASU researchers develop new device to help image key proteins at room temperature
11. With sinus study, Saint Louis University researchers find that harmless members of microbiome spark immune reaction
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers discover a tumor suppressor gene in a very aggressive lung cancer
(Date:9/15/2014)... Mass. (September 15, 2014) The so-called central ... makes proteinhas long provided a simplified explanation for ... living organisms. , In reality, of course, ... schema first articulated nearly 60 years ago by ... double-helix structure. For one, there are multiple types ...
(Date:9/15/2014)... both plants and animals alike. , Understanding just how ... to the design of better drugs for diabetes patients ... vegetables farmers are able to grow. Stanford University researchers ... cell by piecing together proteins slightly wider than the ... determine the size, shape and orientation of one of ...
(Date:9/15/2014)... will allow us to better understand how the ... scenarios and provide the type of environmental data ... and siting of protected areas," said Paula Whitfield, ... Coastal Ocean Science (NCCOS) and lead author of ... within the temperate-tropical transition zone, where historically, both ...
Breaking Biology News(10 mins):Scientists discover RNA modifications in some unexpected places 2X-rays unlock a protein's SWEET side 2X-rays unlock a protein's SWEET side 3Study finds warming Atlantic temperatures could increase range of invasive species 2
... D.C., November 21, 2010 -- For centuries, hunters have imitated ... carving wooden bird calls. Now a team of physicists at ... characteristics of real bird song with a simple physical model ... know if you [could] build a simple device, which has ...
... baby,s first blurted "bowl!," for the word "ball" to the ... vocalizations is one of humankind,s most remarkable attributes -- and ... Not so for people who are afflicted with ... stigma of affected speech. Nor so for engineering professor Michael ...
... , Researchers in the United States have developed a ... from a patient,s own bone marrow. The research, published ... suffering from abnormally developed bladders, but also represents another ... research, led by Dr Arun Sharma and Earl Cheng ...
Cached Biology News:Simple rubber device mimics complex bird songs 2Air flows in mechanical device reveal secrets of speech pathology 2New study into bladder regeneration heralds organ replacement treatment 2
(Date:9/15/2014)... phase transitionsthink solid, liquid, and gasbut much ... drops. If phase transitions occur at the ... subtle fluctuations can dramatically transform a material. ... of Energy,s Brookhaven National Laboratory and Stony ... of absolute zero to isolate and probe ...
(Date:9/15/2014)... North Carolina State University have developed a technique for ... very low voltages, opening the door to a new ... The technique hinges on the fact that the oxide ... or removed acts as a surfactant, lowering the ... , The researchers used a liquid metal alloy of ...
(Date:9/15/2014)... , Sept. 15, 2014 Zymo ... viral transport solution for safe ambient temperature storage ... molecular testing. Importantly, the infectivity of agents in such ... maintaining the integrity of the viral nucleic acids ... the recent Ebola epidemic in West ...
(Date:9/15/2014)... September 2014 Die zweite jährliche ... 12. bis 18. Oktober stattfinden. Die IPAW ist ... Association (PPTA) und ihrer Mitgliedsunternehmen ... globale Bewusstsein für die Gewinnung von Quellplasma zu ... Retten und Verbessern von Leben zu würdigen ...
Breaking Biology Technology:Elusive quantum transformations found near absolute zero 2Elusive quantum transformations found near absolute zero 3Researchers control surface tension to manipulate liquid metals 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 3International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 2International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 3
... FRANCISCO, Calif., Nov. 1, 2010 diaDexus, Inc. (OTC ... focused on the development and commercialization of patent-protected ... cardiovascular disease, today announced that the company, formerly known ... Board under the ticker symbol (VXGN), has been renamed ...
... Nov. 1, 2010 Amgen (Nasdaq: AMGN ) ... Ph.D., will urge members of a U.S. Food and Drug ... to establish approval standards that ensure patient safety and follow ... policy will follow," Dr. Miletich said.  "Amgen believes biosimilars have ...
... ... ... var shortURL = ""; BitlyCB.alertResponse = function(data) ... first one. for (var r in data.results) { first_result = data.results[r]; break; } for (var key in first_result) { ...
Cached Biology Technology:diaDexus Announces Name Change From VaxGen 2diaDexus Announces Name Change From VaxGen 3Amgen to Provide Testimony at FDA Hearing on Biosimilars 2Amgen to Provide Testimony at FDA Hearing on Biosimilars 3Amgen to Provide Testimony at FDA Hearing on Biosimilars 4NEURO-BIOTECH CORPORATION: Updates and latest developments 2NEURO-BIOTECH CORPORATION: Updates and latest developments 3NEURO-BIOTECH CORPORATION: Updates and latest developments 4NEURO-BIOTECH CORPORATION: Updates and latest developments 5NEURO-BIOTECH CORPORATION: Updates and latest developments 6NEURO-BIOTECH CORPORATION: Updates and latest developments 7NEURO-BIOTECH CORPORATION: Updates and latest developments 8NEURO-BIOTECH CORPORATION: Updates and latest developments 9
... Daltonics and Bruker BioSpins Metabolic Profiler ... studies, and analysis of complex mixtures. ... an optional Avance NMR spectrometer and ... and statistical analysis for applications like:,Assessment ...
... movements in a Morris Water Maze. Tracks ... predefined sequence of trials.The Spatial Behavior line is ... video camera, frame grabber, and feature extraction software ... and up to 6 moving animals. Software ...
... Object Records behavior directed toward examining a novel ... a family of instruments all built around a ... and that can track two fields at once ... automatically extracts animal positions and records them, but ...
... ACS Reagent Grade C 19 H 9 ... 691.95 PRODUCT SPECIFICATIONS Form: Powder Clarity of ... pH 3.0 - Yellow pH 4.6 ... dye in agarose and acrylamide gel electrophoresis. ...
Biology Products: