Navigation Links
Researchers discover a switch that controls stem cell pluripotency
Date:9/15/2011

TorontoScientists have found a control switch that regulates stem cell "pluripotency," the capacity of stem cells to develop into any type of cell in the human body. The discovery reveals that pluripotency is regulated by a single event in a process called alternative splicing.

Alternative splicing allows one gene to generate many different genetic messages and protein products. The researchers found that in genetic messages of a gene called FOXP1, the switch was active in embryonic stem cells but silent in "adult" cellsthose that had become the specialized cells that comprise organs and perform functions.

"It opens the field to the fact that alternative splicing plays a really important role in stem cell pluripotency," said Prof. Benjamin Blencowe, principal investigator on the study and a Professor in the University of Toronto's Departments of Molecular Genetics and Banting and Best Department of Medical Research. "We're beginning to see an entirely new landscape of regulation, which will be crucial to our understanding of how to produce more effective pluripotent stem cells for therapeutic and research applications."

The findings were published in the current online edition of the scientific journal Cell.

Alternative splicing works by allowing different segments of genetic messages, also known as messenger RNAs, to be spliced in different combinations as the messages are copied from a gene's DNA. Those combinations make different messenger RNAs, which in turn become different proteins.

In stem cells, scientists have shown that a core set of proteins called transcription factors control pluripotency.

The splicing event discovered by Blencowe's team, including first author on the study Dr. Mathieu Gabut, changes the DNA binding properties of FOXP1 in a way that then controls the expression of the core pluripotency transcription factors, to facilitate maintenance of pluripotency. "As a mechanism that
'/>"/>

Contact: Jim Oldfield
jim.oldfield@utoronto.ca
416-946-8423
University of Toronto
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. MU researchers unveil new method for detecting lung cancer in Nature article
2. Notre Dame researchers demonstrate antibiotic sensing event central to MSRA antibiotic resistance
3. Researchers uncover a potential new benefit of pure maple syrup on liver health
4. EPA grants help Wayne State researchers stave off Great Lakes environmental invaders
5. UTHealth, BCM researchers find common gene variant associated with aortic dissection
6. Researchers find high levels of toxic PCBs in Indiana Harbor and Ship Canal
7. UH researchers work to develop screening method for superbug
8. Researchers find hormone that predicts premature death in kidney patients
9. Chinese researchers identify insect host species of a famous Tibetan medicinal fungus
10. Researchers publish study on neuronal RNA targeting
11. Researchers identify new drug target that stimulates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/11/2015)... , June 11, 2015 Daon, ... announced today that its IdentityX Mobile Authentication Platform ... IDentity Online) Alliance is an industry consortium launched ... standards for simpler, stronger authentication.  In order to ... pass a rigorous series of tests that measure ...
(Date:6/9/2015)... June 9, 2015   MedNet Solutions , an ... spectrum of clinical research, will be providing demonstrations of ... at the 2015 Drug Information Association (DIA) Annual Meeting ... 15-17.  These presentations will include previews of many exciting ... the upcoming iMedNet 2015 Feature 1 Release. ...
(Date:6/8/2015)... 2015  Trovagene, Inc. (NASDAQ: TROV ), a developer ... its Precision Cancer Monitoring SM platform will be presented ... in San Diego, CA on June ... Integrating Clinical Genomics and Cancer Therapy in ... "We continue to advance our clinical programs and ...
Breaking Biology News(10 mins):Daon's IdentityX Mobile Authentication Platform One of First Products to be Certified by FIDO Alliance 2MedNet To Provide Sneak Peeks Of Its iMedNet "2015 Feature 1 Release" At The DIA Annual Meeting 2MedNet To Provide Sneak Peeks Of Its iMedNet "2015 Feature 1 Release" At The DIA Annual Meeting 3Clinical Data Featuring Trovagene's Urine-Based Liquid Biopsy Platform to be Presented at Two Upcoming Medical Conferences 2Clinical Data Featuring Trovagene's Urine-Based Liquid Biopsy Platform to be Presented at Two Upcoming Medical Conferences 3Clinical Data Featuring Trovagene's Urine-Based Liquid Biopsy Platform to be Presented at Two Upcoming Medical Conferences 4
... Ind. - Discovery that a specific gene is integral to ... deadly toxin in the kernels may lead to ways to ... evaluated the fungal gene ZFR1 and found that it is ... kernels. Production of the toxin decreased when the scientists disabled ...
... Simplifying the process for forming compounds that can be ... plastics, has earned one University of Houston chemist a ... of chemistry in the College of Natural Sciences and ... mathematicians and economists in the United States and Canada ...
... Bioscience Horizons, a unique peer-reviewed journal comprising entirely of ... and Republic of Ireland. Bioscience Horizons ( ... the universities of Leeds, Nottingham, Reading, Chester and Trinity ... forum for the brightest undergraduates in the UK and ...
Cached Biology News:Defining gene's role may lead to prevention of dangerous corn toxin 2Defining gene's role may lead to prevention of dangerous corn toxin 3Simplifying manufacture of drugs, plastics earns UH chemist top honor 2
(Date:7/1/2015)... CA (PRWEB) , ... July 01, 2015 , ... It ... brain injury (TBI) using single photon emission computed tomography (SPECT) according to ... The study, which examined over 20,000 brain scans and is believed to be the ...
(Date:7/1/2015)... July 1, 2015   Neuraltus Pharmaceuticals, Inc. ... of groundbreaking drugs to treat neurodegenerative diseases such ... Robert G. Miller , M.D., Director of the ... California Pacific Medical Center in San Francisco, has been ... $1.5 million to help fund a Phase 2 ...
(Date:7/1/2015)... ... July 01, 2015 , ... Apex Therapeutics announced today ... Convention in Philadelphia, PA. , The presentation took place on Tuesday, June ... plans for the development of APX3330 for the treatment of pancreatic cancer. A ...
(Date:6/30/2015)... 30, 2015 /PRNewswire/ - Resverlogix Corp. ("Resverlogix") (TSX:RVX) ... of Resverlogix have approved the resolutions relating to: ... of 5,600,000 units at a price of $2.67 ... being comprised of one common share and 0.075358 ... approximately CAD$15 million; and (ii) the amendment to ...
Breaking Biology Technology:Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 3
... Speid & Associates, an international regulatory and drug ... entered into a partnership with Genizon BioSciences to ... Genizon,s proprietary genetic platform. In this challenging ... companies have to watch every dollar that is ...
... bio-manufacturing process to produce methyl ethyl ketone from ... 25 Researchers at Genomatica, Inc., a sustainable ... methyl ethyl ketone (MEK), a commonly used industrial ... than $2 billion. The rapid development breakthrough ...
... Therapeutics,(Nasdaq: NKTR ) today reported its ... December 31, 2008. , ... Howard W. Robin,President and Chief Executive Officer of ... we advanced numerous proprietary drug,candidates into clinical and ...
Cached Biology Technology:Speid & Associates Partners With Genizon BioSciences to Reduce Attrition Rates of New Drug Compounds 2New Genomatica Chemical Process Targets Ailing Ethanol Assets 2New Genomatica Chemical Process Targets Ailing Ethanol Assets 3New Genomatica Chemical Process Targets Ailing Ethanol Assets 4New Genomatica Chemical Process Targets Ailing Ethanol Assets 5Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 2Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 3Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 4Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 5Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 6Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 7Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 8Nektar Therapeutics Reports Fourth Quarter and Year-End 2008 Financial Results 9
... The binding specificity and signaling of ... known to be modified by alternative splicing--which ... GPCR SpliceArrays you can perform a classical ... detect the different alternatively spliced forms of ...
... sensitivity of DNA detection has been improved. With ... agarose gel can be detected > 20 ng. ... purified by organic solvent extraction or with other ... well.) DNA excised from agarose gel can ...
Mouse monoclonal antibody raised against a partial recombinant ST3GAL2. NCBI Entrez Gene ID = ST3GAL2...
... Serum-free adapted Sf9 derivative for high-yield ... Sf9 Cells are derived from a high-yielding ... in Novagen serum-free TriEx Insect Cell Medium, ... and protein yields by either baculovirus infection ...
Biology Products: