Navigation Links
Researchers discover 'Achilles' heel' for lymphoid leukemia
Date:2/11/2013

An international research team coordinated at the IRCM in Montral found a possible alternative treatment for lymphoid leukemia. Led by Dr. Tarik Mry, the IRCM's President and Scientific Director, the team discovered a molecule that represents the disease's "Achilles' heel" and could be targeted to develop a new approach that would reduce the adverse effects of current treatments such as chemotherapy and radiation therapy. The study's results are being published today in the prestigious scientific journal Cancer Cell.

The researchers' results have direct implications for the treatment of acute lymphoblastic leukemia (ALL), one of the four most common types of leukemia. ALL is a cancer of the bone marrow and blood that progresses rapidly without treatment. Current treatments consist of chemotherapy and radiation therapy, which are both highly toxic and non-specific, meaning that they damage healthy cells as well as tumour tissues.

"Even when effective, patients can suffer dramatic side effects from these treatments," says Dr. Mry, who is also Director of the Hematopoiesis and Cancer research unit at the IRCM and corresponding author of the study. "Therefore, they would directly benefit from an improved therapy that could reduce the necessary dose of radiation or chemotherapy, and thus their side effects, while maintaining the treatments' efficacy. Therapies that target specific molecules have shown great promise. This is why, for the past 20 years, I have been studying a molecule called Gfi1, which plays an important role in the development of blood cells and cancer."

When normal cells are transformed into tumour cells, the body responds by activating a tumour suppressor protein that induces cell death. Tumour cells must therefore counteract cell death in order to survive.

"With this study, we found that leukemic cells depend on the Gfi1 molecule for their survival," explains Dr. Cyrus Khandanpour, co-first author of
'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers find Asian needle ants displacing other aggressive invaders
2. Spanish researchers design biomarkers for the detection of dengue and West Nile virus
3. UT Dallas researchers pushing the boundaries of virtual reality
4. Polar bear researchers urge governments to act now and save the species
5. Pitt researchers reveal mechanism to halt cancer cell growth, discover potential therapy
6. Researchers discover mutations linked to relapse of childhood leukemia
7. Caught in the act: Researchers capture key moments in cell death
8. Researchers harness nature to produce the fuel of the future
9. U. of Minn. researchers unveil first artificial enzyme created by evolution in a test tube
10. Prehistoric humans not wiped out by comet, says researchers
11. Clemson University researchers to study oil and gas operations impact on Gulf Coast pelicans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... elements are a key component of phloem, the conductive ... range of signalling molecules. Elongated cylindrical cells are capped ... end-to-end to form sieve tubes which in turn form ... "Sieve elements are very special cells which play an ... little has been known about their differentiation," says Professor ...
(Date:8/1/2014)... Fla. , Aug. 1, 2014  LiveScan Service Provider Binary Biometrics ... owner/operator team. As a result, Binary Biometrics will improve its mobile service capabilities ... Volusia County and service several new cities such as, ... , DeLand , Deltona , ... Helen , New Smyrna Beach , Oak ...
(Date:7/31/2014)... supported by the National Science Foundation (NSF), counters ... accelerates atmospheric warming, indicating instead that certain Arctic ... into the atmosphere. , The study, published ... focuses on thermokarst lakes, which occur as permafrost ... melted fresh water, converting what was previously frozen ...
Breaking Biology News(10 mins):Developmental regulation of important plant phloem components discovered 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 3Certain Arctic lakes store more greenhouse gases than they release 2
... On the first anniversary of the American Recovery and ... nation,s research universities today provided nearly 100 examples of ... paying outsize short- and long-term dividends for the nation. ... $21.5 billion is allocated for research and science infrastructure. ...
... Medical Inc. has obtained a non-exclusive license to ... property developed at Case Western Reserve University,s Department ... (FES) Center in Cleveland. ... manufacturer based in Indiana, Pa., rights to intramuscular ...
... multitude of questions, but sometimes traditional techniques are superior. ... cost, when they relied upon statistical data to monitor ... an indigenous group of people living in the James ... Montreal), have lived in harmony with their environment. They ...
Cached Biology News:Universities highlight benefits of stimulus research funding 2Universities highlight benefits of stimulus research funding 3Listen to the natives for better moose monitoring 2
(Date:8/1/2014)... 2014 AACC, a global scientific and medical ... unveiled an updated brand identity today that reflects the ... changing healthcare environment and continue to do what they ... get the care they need. " ... an essential role in saving lives and making people ...
(Date:8/1/2014)... , August 1, 2014 According ... Research "Biophotonics Market - Global Industry Analysis, Size, Share, ... was valued at USD 25.16 billion in 2013, which ... growing at a CAGR of 10.4% from 2014 to ... at  http://www.transparencymarketresearch.com/biophotonics-market.html Increasing demand for accurate ...
(Date:8/1/2014)... Mass. (PRWEB) August 01, 2014 BCC ... RNAi DRUG DELIVERY: TECHNOLOGIES AND GLOBAL MARKETS , ... technologies is expected to grow to nearly $38.8 billion ... (CAGR) of 27.2%. The aptamer delivery category, the fastest ... phenomenal 58.2% CAGR. , The field of RNAi therapeutics ...
(Date:8/1/2014)... Testing the mechanical properties of microtissues ... embryonic development. How and why embryonic stem ... distinct tissues is important because abnormalities can lead ... Melissa Kinney, and Rabbia Saeed worked from the ... to control many aspects of embryo development. ...
Breaking Biology Technology:AACC Debuts Refreshed Brand Identity 2Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 2Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 3Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 4Global Market for RNAi Drug Delivery Technologies to Reach $38.8 Billion in 2018; Aptamer Delivery Segment Surging at 58.2% CAGR 2Global Market for RNAi Drug Delivery Technologies to Reach $38.8 Billion in 2018; Aptamer Delivery Segment Surging at 58.2% CAGR 3Study Links Biomechanics and Gene Expression in Stem Cells 2
... N.C., June 9, 2011 The David H. Murdock ... Immune Tolerance Institute, Inc. (ITI) as a next step ... the North Carolina Research Campus in Kannapolis, NC. Driven ... of breakthrough treatments for the range of immune-related diseases, ...
... all advanced a few steps closer to their future ... the week of May 9-13, 2011. That,s when ... three of the four robotics competitions at the IEEE ... China. The trio of contests are designed to prove ...
... 2011 Ronald W. Davis, PhD, a pioneer in innovative ... and genomic methods to biological organisms, will receive the 2011 ... Davis, 69, has spent most of his professional ... biochemistry and genetics. He also serves as director of the ...
Cached Biology Technology:David H. Murdock Research Institute Assumes Control of the Immune Tolerance Institute and Establishes a State of the Art Human Immune Monitoring Laboratory for Biomarker Discovery and Development 2David H. Murdock Research Institute Assumes Control of the Immune Tolerance Institute and Establishes a State of the Art Human Immune Monitoring Laboratory for Biomarker Discovery and Development 3NIST contests in China put next-gen robot technologies to the test 2NIST contests in China put next-gen robot technologies to the test 3Biochemist and Geneticist Ronald W. Davis Receives $500,000 Gruber Genetics Prize for Pioneering Work in the Development of Biotechnologies that Have Significantly Advanced the Fields of Molecular Genetics and Genomics 2Biochemist and Geneticist Ronald W. Davis Receives $500,000 Gruber Genetics Prize for Pioneering Work in the Development of Biotechnologies that Have Significantly Advanced the Fields of Molecular Genetics and Genomics 3
... long electrophoresis hood is a ... systems. Placed on the transilluminator, ... place and provides a darkroom ... the lab bench. This 15.2 ...
... derived from frozen embedded tissue blocks, which ... to ensure the highest quality. Tissues of ... block, sectioned at a thickness of 7 ... are large (3-5 mm in diameter) in ...
... are derived from frozen embedded tissue blocks, ... procedures to ensure the highest quality. Tissues ... one block, sectioned at a thickness of ... are large (3-5mm in diameter) in comparison ...
... microarrays are derived from Paraffin embedded tissue ... control procedures to ensure the highest quality. ... in one block, sectioned at a thickness ... slides. Sections are large (3-5mm in diameter) ...
Biology Products: