Navigation Links
Researchers devise means to create blood by identifying earliest stem cells
Date:8/29/2008

Johns Hopkins researchers have discovered the earliest form of human blood stem cells and deciphered the mechanism by which these embryonic stem cells replicate and grow. They also found a surprising biological marker that pinpoints these stem cells, which serve as the progenitors for red blood cells and lymphocytes.

The biochemical marker, angiotensin-converting enzyme (ACE), is well known for its role in the regulation of blood pressure, blood vessel growth, and inflammation. ACE inhibitors are already widely used to treat hypertension and congestive heart failure, and the findings are, the researchers say, likely to hold promise for developing new treatments for heart diseases, anemias, leukemia and other blood cancers, and autoimmune diseases because they show for the first time that ACE plays a fundamental role in the very early growth and development of human blood cells.

"We figured out how to get the 'mother' of all blood stem cells with the right culture conditions," says Elias Zambidis, M.D., Ph.D., of the Institute of Cell Engineering at the Johns Hopkins University School of Medicine and the Division of Pediatric Oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.

"There is real hope that in the future we can grow billions of blood cells at will to treat blood-related disorders, and just as critically if not more so, we've got ACE as a 'new' old marker to guide our work," Zambidis adds.

Researchers did not expect ACE to have a role in blood stem cells, he notes, "but were very pleasantly surprised to discover it as a beacon for finding the earliest blood stem cells known, as well as new ways to find and manipulate this marker to make them grow."

The team's findings, published Aug. 26 in the online edition of the journal Blood, explain that these earliest stem cells marked by ACE, called hemangioblasts, first arise normally in the developing human
'/>"/>

Contact: Valerie Mehl
mehlva@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers discover atomic bomb effect results in adult-onset thyroid cancer
2. Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
3. Indiana U researchers launch social networking and research management tool for scientists
4. UC Davis researchers define characteristics, treatment options for XXYY syndrome
5. Munich researchers discover key allergy gene
6. Rapid test for pathogens developed by K-State researchers
7. OU researchers isolate microorganisms that convert hydrocarbons to natural gas
8. UH researchers win top prize for research with humanitarian applications
9. Caltech researchers awarded $10M for molecular programming project
10. Researchers study facial structures, brain abnormalities to reveal formula for detection of autism
11. Mount Sinai researchers discover technology that silences genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... FOREST, Calif. , March 3, 2015 ... the leading provider of advanced cryogenic logistics ... markets including immunotherapies, stem cells, cell lines, ... and reproductive medicine, today announced the expansion ... Cancer Research Centers, ("Fred Hutch") Clinical ...
(Date:3/2/2015)...  Businesses have a new option for premier ... Enterprises has announced the launch of a brand ... businesses to protect their customers, personal data, as ... Beconux is a biometric transaction processing system recently ... an ATM machine, the new system fuses multiple ...
(Date:2/25/2015)... Feb. 25, 2015  ABC Financial Services (ABC), ... the Health and Fitness Industry, today announced enhancements ... MYiCLUBonline.  The latest upgrade includes advances to the ... cardless check-in via Identity One fingerprint biometrics. The ... through interactive displays at the International Health, Racquet ...
Breaking Biology News(10 mins):Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3Personal Data Protection Company Launches New Product 2ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3
... have identified a component of the herpesvirus that ... to rapidly and successfully invade the nervous system ... associate professor in immunology and microbiology at Northwestern ... viral protein 1-2, or VP1/2, allows the herpesvirus ...
... are not the favourite food choice of many marine ... find out about the chemical weapons they employ when ... which they squirt at unsuspecting peckish predators. However, while ... secretion, how the whitish and viscous opaline outsmarts a ...
... laboratory study pairing food chemistry and cancer biology, scientists at ... effect of foods and flavorings on the DNA of cells. ... and coffee activated the highest levels of a well-known, cancer-linked ... DNA is damaged. Its gene product makes repair proteins that ...
Cached Biology News:How herpesvirus invades nervous system 2Sea hares outsmart peckish lobsters with sticky opaline 2Cancer biologists find DNA-damaging toxins in common plant-based foods 2
(Date:3/25/2015)... UK (PRWEB) March 25, 2015 An ... natural ingredients in all forms of food nutrients, regulatory ... to a substantial rise in demand for natural astaxanthin ... have started to ramp up their capacities to satisfy ... both natural and synthetic source astaxanthin (used in nutraceuticals, ...
(Date:3/25/2015)... Having added two International locations in ... 2014, ITRA Global proudly announced recently the organization’s expansion ... Alliance, based in the United States, is one of ... of commercial real estate. , Saltwood International ... that exclusively advises occupiers of office space, ensuring that ...
(Date:3/25/2015)... March 25, 2015  The Technology Association of ... dedicated to the promotion and economic advancement of ... Health as one of its Top 40 Innovative Technology ... recognize this prestigious group at the 2015 Georgia Technology ... Galleria Centre. TAG,S Top 40 Awards recognize ...
(Date:3/25/2015)... 25, 2015 FDNA®, the pioneer ... of Face2Gene, allowing geneticists around the globe ... well as mobile devices. Face2Gene® facilitates detection of facial ... present comprehensive and up-to-date genetic references. The date of ... ACMG 2015, in Salt Lake City, UT ...
Breaking Biology Technology:Global Astaxanthin Market to Reach Value of USD 1.1 billion by 2020, Expects Industry Experts in New Report Available at MarketPublishers.com 2International Organization Expands its Global Reach to Warsaw, Poland 2Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 2Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 3Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 4FDNA Releases a Multi-Platform Version of Face2Gene, a Genetic Search and Reference Solution at ACMG 2015 2
... Information Systems announced last week it has achieved ... represents the highest level of partnership and, according to ... in three specializations in addition to achieving a measurable ... IP Telephony, VPN Security and wireless LAN. , ...
... Like most states, Wisconsin has long offered specialized tax ... has lacked credit programs aimed at leveraging seed capital ... change. Act 255, a tax-credit package that passed the ... an administrative rule process this summer, will provide a ...
... , a unit of Fiserv, Inc. , ... for its clients that have licensed the Nautilus ... multiple-option service is designed to ensure that financial ... interruption, after virtually any hardware, software or operational ...
Cached Biology Technology:Inacom Information Systems achieves Cisco Systems Partner -Gold Certified status 2State investment incentives aimed at luring angels to start-up companies 2
... Presenilin 2 Alzheimer's disease (AD) patients ... carry mutations in the presenilin proteins (PSEN1; ... These disease-linked mutations result in increased production ... component of amyloid deposits found in AD ...
One-step, microplate or cuvet, colorimetric, linear detection range 6 mg/dL to 100mg/dL. Procedure: 15 min....
[5,6,8,9,12,14,15(n)-3H]Prostaglandin D2, 925 kBq, 25 uCi. Methanol:water:acetonitrile (3:2:1) solution.> 3.0 TBq/mmol, > 80 Ci/mmol.3.7 MBq/ml, 100 uCi/ml. Category: Radiochemicals &Radiation Safety...
... Design with Purpose -- ... MS provide the highest level ... performance in an affordable, easy-to-use ... autosampler and workstation guarantees success ...
Biology Products: