Navigation Links
Researchers devise means to create blood by identifying earliest stem cells
Date:8/29/2008

Johns Hopkins researchers have discovered the earliest form of human blood stem cells and deciphered the mechanism by which these embryonic stem cells replicate and grow. They also found a surprising biological marker that pinpoints these stem cells, which serve as the progenitors for red blood cells and lymphocytes.

The biochemical marker, angiotensin-converting enzyme (ACE), is well known for its role in the regulation of blood pressure, blood vessel growth, and inflammation. ACE inhibitors are already widely used to treat hypertension and congestive heart failure, and the findings are, the researchers say, likely to hold promise for developing new treatments for heart diseases, anemias, leukemia and other blood cancers, and autoimmune diseases because they show for the first time that ACE plays a fundamental role in the very early growth and development of human blood cells.

"We figured out how to get the 'mother' of all blood stem cells with the right culture conditions," says Elias Zambidis, M.D., Ph.D., of the Institute of Cell Engineering at the Johns Hopkins University School of Medicine and the Division of Pediatric Oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.

"There is real hope that in the future we can grow billions of blood cells at will to treat blood-related disorders, and just as critically if not more so, we've got ACE as a 'new' old marker to guide our work," Zambidis adds.

Researchers did not expect ACE to have a role in blood stem cells, he notes, "but were very pleasantly surprised to discover it as a beacon for finding the earliest blood stem cells known, as well as new ways to find and manipulate this marker to make them grow."

The team's findings, published Aug. 26 in the online edition of the journal Blood, explain that these earliest stem cells marked by ACE, called hemangioblasts, first arise normally in the developing human
'/>"/>

Contact: Valerie Mehl
mehlva@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

6

GOOD

Page: 1 2 3

Related biology news :

1. Researchers discover atomic bomb effect results in adult-onset thyroid cancer
2. Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
3. Indiana U researchers launch social networking and research management tool for scientists
4. UC Davis researchers define characteristics, treatment options for XXYY syndrome
5. Munich researchers discover key allergy gene
6. Rapid test for pathogens developed by K-State researchers
7. OU researchers isolate microorganisms that convert hydrocarbons to natural gas
8. UH researchers win top prize for research with humanitarian applications
9. Caltech researchers awarded $10M for molecular programming project
10. Researchers study facial structures, brain abnormalities to reveal formula for detection of autism
11. Mount Sinai researchers discover technology that silences genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2009)...ation of the centromere, a key cellular structure ... and accurate cell division, has just earned him a...EMBO installation grant, of 50,000 euro per year, ... from California to the Instituto Gulbenkian de Ci...genetic Mechanisms group. The Nature Cell Biology...
(Date:7/1/2009)...ssociation has released an updated position paper ...well-planned, are healthful and nutritious for adu...p prevent and treat chronic diseases including hea...s position, published in the July issue of the Jo...sents the Association,s official stance on vegetar...
(Date:7/1/2009)... the first time, researchers have been able to ide...or failure of IVF treatment in blood. Dr. Cathy Al...old the 25th annual conference of the European Soc...ednesday 1 July) that her research would help unde... others. , Previous work in this area has looked...
(Date:6/30/2009)...act that cognitive function declines as we get old...pecific kind of daily activities we engage in duri...e extent of this decline. A team of researchers fr...ivision of labour among honey bees affects their l...y have found that, by switching their social role,...
Breaking Biology News(10 mins):Double success for Instituto Gulbenkian de Ciencia scientists working on chromosome segregation 2ADA releases updated position paper on vegetarian diets 2Will IVF work for a particular patient? The answer may be found in her blood 2Will IVF work for a particular patient? The answer may be found in her blood 3A young brain for an old bee 2Antioxidant Rich Foods Lose Nutritional Luster Over Time 41436 1Antioxidant Rich Foods Lose Nutritional Luster Over Time 41436 2Antioxidant Rich Foods Lose Nutritional Luster Over Time 41436 3Antioxidant Rich Foods Lose Nutritional Luster Over Time 41436 42009 Society for Research in Child Development biennial meeting 41434 1Genesis Pharmaceuticals Affirms Operating Income Guidance Adjusts Revenue Guidance for Fiscal 2009 41431 1Genesis Pharmaceuticals Affirms Operating Income Guidance Adjusts Revenue Guidance for Fiscal 2009 41431 2Genesis Pharmaceuticals Affirms Operating Income Guidance Adjusts Revenue Guidance for Fiscal 2009 41431 3Rib X Pharmaceuticals Novel Antibiotic Delafloxacin Named One of R 26D Directions 100 Great Investigational Drugs of 2009 4122 1Rib X Pharmaceuticals Novel Antibiotic Delafloxacin Named One of R 26D Directions 100 Great Investigational Drugs of 2009 4122 2Rib X Pharmaceuticals Novel Antibiotic Delafloxacin Named One of R 26D Directions 100 Great Investigational Drugs of 2009 4122 3Rib X Pharmaceuticals Novel Antibiotic Delafloxacin Named One of R 26D Directions 100 Great Investigational Drugs of 2009 4122 4
...ina at Chapel Hill has identified and established ...ntially dangerous interactions with certain medica...d by their doctors and pharmacists to avoid grapef...medications, including some drugs that control blo...wn that grapefruit juice can cause more of these d...
...ing resistance to existing antiviral drugs is abou...rals. Called PA-457, it is the first of a new clas...rs. The drug is still in its early stages, and wil...ars. , Up to 80 per cent of HIV positive people on... drugs, according to Graham Allaway of Panacos Pha...
...y report in this month,s issue of Genome Research...rprint in the pathogen responsible for potato blig... copies of a specific gene, while other strains po...o not recognize strains of the pathogen with only ...nfection. This is the first report of gene amplif...
...bles has been developed, which quite literally suc... in place ozone-depleting chemicals, like methyl b...h produce. , The technique, called metabolic stre...gunas-Solar and his team at University of Californ...culture DOI 10.1002/jsfa2538). , Tim Essert, the...
Other Biology News:Study identifies substances in grapefruit juice that interact dangerously with some drugs 2Trials for new drug to overcome HIV 2Potato blight pathogenicity explained by genome plasticity 2Potato blight pathogenicity explained by genome plasticity 3
(Date:7/1/2009)...orphotek(R), Inc., a subsidiary of Eisai Corporati...ation agreement with Synageva BioPharma Corporatio...tibodies for the potential treatment of various fo... the terms of the agreement, Synageva will use its...) technology and its expertise to produce and deve...
(Date:7/1/2009)...-- SenesTech, Inc., a biotechnology corporation wo...management, announced the appointment of George M.... , , Siegel has over 35 years of business devel...s. He has served as Chairman of the Board of Dire... Inc., Director of ILINC Communications, Inc., and...
(Date:6/30/2009)... and HONG KONG, June 30 ...nounced today that Excalibur,s Ocean LaLa has succ...senger voyage which has been highlighted in multip...g the Taiwan Sun, and the Qatar Tribune. The arti...ruise service with China on Sunday, making it the ...
(Date:6/30/2009)... 30 Microfluidics, a wholly owned ...ion (OTC Bulletin Board: MFLU), and Particle Scien... help biopharmaceutical companies leverage the mos...tion methods available to develop, analyze and com...). , , Particle Sciences is a leading Contract ...
Breaking Biology Technology:Morphotek(R), Inc. Announces a Research Collaboration Agreement with Synageva BioPharma Corporation to Develop Potential Treatments for Cancer and Infectious Disease 2Morphotek(R), Inc. Announces a Research Collaboration Agreement with Synageva BioPharma Corporation to Develop Potential Treatments for Cancer and Infectious Disease 3SenesTech Announces New Vice President of Business Development 2Excalibur International Marine (49% Owned by EFT BioTech Holdings) Completes Inaugural Passenger Crossing of Taiwan Strait 2Excalibur International Marine (49% Owned by EFT BioTech Holdings) Completes Inaugural Passenger Crossing of Taiwan Strait 3Particle Sciences and Microfluidics Collaborate to Share Formulation and Nanotechnology Expertise for Pharmaceutical Drug Product Development, Analysis and Commercialization 2Particle Sciences and Microfluidics Collaborate to Share Formulation and Nanotechnology Expertise for Pharmaceutical Drug Product Development, Analysis and Commercialization 3
...tions, Knucklehead! , ,You did it; you brought Bi...ear the cries ringing throughout the Microsoft cam...ng the buildings, all but drowning out the sawing ...impers you could almost hear Billy saying it: "I w...d fix my software."* , ,Wow, if only the U.S. an...
...h advancements can get techies into ballgame, too ...er from its two-year-long nightmare, recent or soo...g things a bit gauche. , ,If they could only see w...d amend that view. Modern numeric control systems,...n staples of the manufacturing sector simply would...
... for example, was funded with $4M in angel money. ... to entrepreneurs. Tech entrepreneurs could apply ...ers , founded by Dick Leazer and Terry Sivesind, a...d Larry Landweber) for investment consideration. A...who were actively looking for precisely these type...
...WI - Automating Peripherals Inc announced that the...ganizations comply with security standards mandate...bility Act of 1996 (HIPAA) and Joint Commission on.... SecurALL is an enterprise-wide access-control sy...and monitor facility access throughout an organiza...
Other Biology Technology:Open Letter: Blasted Worm 2Open Letter: Blasted Worm 3Manufacturing still viable career 2Manufacturing still viable career 3The State of Risk Capital in Wisconsin 2The State of Risk Capital in Wisconsin 3The State of Risk Capital in Wisconsin 4