Navigation Links
Researchers develop software tool for cancer genomics
Date:8/26/2013

Researchers at the Medical College of Wisconsin (MCW) have developed a new bioinformatics software tool designed to more easily identify genetic mutations responsible for cancers. The tool, called DrGaP, is the subject of a new paper published in the American Journal of Human Genetics.

Xing Hua, Ph.D., postdoctoral fellow in biostatistics at the National Cancer Institute, and a former visiting scholar at MCW, is the first author of the paper. Yan Lu, Ph.D., assistant professor of physiology, is corresponding author; and Pengyuan Liu, Ph.D., associate professor of physiology at MCW, is the co-corresponding author.

Cancers are caused by the accumulation of genomic alterations, or mutations. Genomic sequencing identifies two specific types of mutations: driver mutations, which are responsible for cancer, and passenger mutations, which are irrelevant to tumor development. A major challenge in cancer genome sequencing is discriminating between the two types of mutations.

The authors incorporated statistical methods and bioinformatics tools into the computational tool DrGaP, which stands for "Driver Genes and Pathways."

"DrGaP is immediately applicable to cancer genome sequencing studies and will lead a more complete identification of altered driver genes and driver signaling pathways in cancer," said Dr. Liu. "Biological knowledge of the mutation process is fully integrated into the models, and provides several significant improvements and increased power over current methods."

The researchers note that DrGaP not only recaptured a large majority of driver genes previously reported in other studies, but also identified much longer list of additional candidate genes whose mutations may be linked to cancer. This data demonstrates the extreme complexity of tumor cells and has important implications in targeted cancer therapy.


'/>"/>

Contact: Maureen Mack
mmack@mcw.edu
Medical College of Wisconsin
Source:Eurekalert

Page: 1

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/25/2016)... -- Glencoe Software, the world-leading supplier of image data management ... the data management solution OMERO Plus for the newly ... Photo - http://photos.prnewswire.com/prnh/20160125/325328LOGO ... Phenotypic analysis measures the characteristics and behavior of cells, ... such as health and disease, the presence or absence ...
(Date:1/22/2016)... 22, 2016 ... the "Global Biometrics Market in Retail ... --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has ... Biometrics Market in Retail Sector 2016-2020" ... Research and Markets ( http://www.researchandmarkets.com/research/p74whf/global_biometrics ) ...
(Date:1/20/2016)... 20, 2016 A market that just keeps ... from the explosion in genomics knowledge. Learn all about ... A range of dynamic trends are pushing market growth ... medicine - pharmacogenomics - pathogen evolution - next generation ... - greater understanding of the role of genetic material ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... La Jolla CA (PRWEB) , ... February 10, 2016 , ... ... of new agents for the treatment of Alzheimer’s disease, announced today it has been ... to February 18th at the Breakers in Palm Beach, Florida. The purpose of ...
(Date:2/9/2016)... Philadelphia, PA (PRWEB) , ... February 09, 2016 , ... ... balance, the 2016 Wharton Health Care Business Conference will bring together over 500 top ... ahead for an industry in transformation. The conference, organized by MBA students of the ...
(Date:2/9/2016)... ... ... Date and time: March 1, 2016, 5:30 p.m. to ... of Bucks County, 3805 Old Easton Road, Doylestown, PA 18902. , The Baruch ... house for participants to learn about a new Master of Biomedical Science (MBS) ...
(Date:2/9/2016)... Sunnyvale, CA (PRWEB) , ... February 09, 2016 ... ... will present its latest innovations on its free and validated Electronic Data Capture ... Booth #81 the Outsourcing in Clinical Trials West Coast 2016 Conference in San ...
Breaking Biology Technology: