Navigation Links
Researchers develop software tool for cancer genomics
Date:8/26/2013

Researchers at the Medical College of Wisconsin (MCW) have developed a new bioinformatics software tool designed to more easily identify genetic mutations responsible for cancers. The tool, called DrGaP, is the subject of a new paper published in the American Journal of Human Genetics.

Xing Hua, Ph.D., postdoctoral fellow in biostatistics at the National Cancer Institute, and a former visiting scholar at MCW, is the first author of the paper. Yan Lu, Ph.D., assistant professor of physiology, is corresponding author; and Pengyuan Liu, Ph.D., associate professor of physiology at MCW, is the co-corresponding author.

Cancers are caused by the accumulation of genomic alterations, or mutations. Genomic sequencing identifies two specific types of mutations: driver mutations, which are responsible for cancer, and passenger mutations, which are irrelevant to tumor development. A major challenge in cancer genome sequencing is discriminating between the two types of mutations.

The authors incorporated statistical methods and bioinformatics tools into the computational tool DrGaP, which stands for "Driver Genes and Pathways."

"DrGaP is immediately applicable to cancer genome sequencing studies and will lead a more complete identification of altered driver genes and driver signaling pathways in cancer," said Dr. Liu. "Biological knowledge of the mutation process is fully integrated into the models, and provides several significant improvements and increased power over current methods."

The researchers note that DrGaP not only recaptured a large majority of driver genes previously reported in other studies, but also identified much longer list of additional candidate genes whose mutations may be linked to cancer. This data demonstrates the extreme complexity of tumor cells and has important implications in targeted cancer therapy.


'/>"/>

Contact: Maureen Mack
mmack@mcw.edu
Medical College of Wisconsin
Source:Eurekalert

Page: 1

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)...   ivWatch LLC , a medical device company focused on ... receipt of its ISO 13485 Certification, the global standard for medical ... Standardization (ISO®). ... Continuous Monitoring device for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, as ...
(Date:5/23/2017)... GENOA, Italy , May 23, 2017  Hunova, the first robotic ... and trunk, has been officially launched in Genoa, Italy ... Europe and the USA . The ... launched on the market by the IIT spin-off Movendo Technology thanks to ... view the Multimedia News Release, please click: ...
(Date:4/19/2017)... The global military biometrics market ... by the presence of several large global players. The ... major players - 3M Cogent, NEC Corporation, M2SYS Technology, ... 61% of the global military biometric market in 2016. ... military biometrics market boast global presence, which has catapulted ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... Blue Bell, PA and College Station, TX (PRWEB) , ... ... ... IPS-Integrated Project Services, LLC (IPS), a leading global provider ... G-CON Manufacturing, Inc. the leading provider of prefabricated cleanrooms, today announced the ...
(Date:9/20/2017)... (PRWEB) , ... September 20, 2017 , ... ... integration, and building management solutions, announced today the opening of an office in ... Taiwan and the Greater China region, while developing new relationships in the region. ...
(Date:9/19/2017)... Vernon HIlls, IL (PRWEB) , ... September 19, 2017 , ... ... use, harsh environments and time. The pocket testers even stand upright with a new ... in the lab or out in the field who need to test water quality. ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... DFS) cybersecurity regulations have transitioned into full force and effect. The law ... state (“Covered Entities”) to conduct an annual, professional, comprehensive cybersecurity risk assessment, ...
Breaking Biology Technology: