Navigation Links
Researchers develop software tool for cancer genomics
Date:8/26/2013

Researchers at the Medical College of Wisconsin (MCW) have developed a new bioinformatics software tool designed to more easily identify genetic mutations responsible for cancers. The tool, called DrGaP, is the subject of a new paper published in the American Journal of Human Genetics.

Xing Hua, Ph.D., postdoctoral fellow in biostatistics at the National Cancer Institute, and a former visiting scholar at MCW, is the first author of the paper. Yan Lu, Ph.D., assistant professor of physiology, is corresponding author; and Pengyuan Liu, Ph.D., associate professor of physiology at MCW, is the co-corresponding author.

Cancers are caused by the accumulation of genomic alterations, or mutations. Genomic sequencing identifies two specific types of mutations: driver mutations, which are responsible for cancer, and passenger mutations, which are irrelevant to tumor development. A major challenge in cancer genome sequencing is discriminating between the two types of mutations.

The authors incorporated statistical methods and bioinformatics tools into the computational tool DrGaP, which stands for "Driver Genes and Pathways."

"DrGaP is immediately applicable to cancer genome sequencing studies and will lead a more complete identification of altered driver genes and driver signaling pathways in cancer," said Dr. Liu. "Biological knowledge of the mutation process is fully integrated into the models, and provides several significant improvements and increased power over current methods."

The researchers note that DrGaP not only recaptured a large majority of driver genes previously reported in other studies, but also identified much longer list of additional candidate genes whose mutations may be linked to cancer. This data demonstrates the extreme complexity of tumor cells and has important implications in targeted cancer therapy.


'/>"/>

Contact: Maureen Mack
mmack@mcw.edu
Medical College of Wisconsin
Source:Eurekalert

Page: 1

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 /PRNewswire/ - Today, FindBiometrics, the leading source of biometrics industry ... new website design. "When we launched FindBiometrics 12 ... Peter O,Neill , founder and CEO of FindBiometrics. "Now it,s ... from the key players on a very broad scale.  We ...
(Date:1/22/2015)... Inc. (NASDAQ: NXTD and NXTDW) a biometric authentication company ... of the Wocket™ smart wallet at CES 2015 in Las ... one of the "11 Hot Products at CES" in a review published ... Far" by Newseveryday.com and "The top 10 gadgets from CES 2015" by ...
(Date:1/22/2015)... NEW YORK , Jan. 22, 2015   EyeLock, Inc. ... announced it has appointed Steve Gerber to the ... Gerber will be responsible for leading development of mobile platforms ... 25 years of success and innovation in the semiconductor industry ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2
... enable the deadly enterohemorrhagic Escherichia coli (EHEC) ... cells that line the digestive tract, according to a ... journal of the American Society for Microbiology. Gram-negative ... syringe-like weapons called type III secretion systems (T3SS) that ...
... (January 13, 2014) The Damon Runyon Cancer ... innovative early career researchers, named 15 new Damon ... review. The recipients of this prestigious, three-year ... translational cancer research in the laboratories of leading ...
... from Wisconsin will participate in a joint pilot program ... send them to a Chilean research station this February ... The U.S. students and teacher, from the ... peers--winners of Chile,s Antarctic School Fair--in the first Joint ...
Cached Biology News:Little but lethal -- small RNAs coordinate bacterial attack on epithelial cells 2Damon Runyon Cancer Research Foundation grants prestigious awards to 20 top young scientists 2Damon Runyon Cancer Research Foundation grants prestigious awards to 20 top young scientists 3Damon Runyon Cancer Research Foundation grants prestigious awards to 20 top young scientists 4Damon Runyon Cancer Research Foundation grants prestigious awards to 20 top young scientists 5Damon Runyon Cancer Research Foundation grants prestigious awards to 20 top young scientists 6Damon Runyon Cancer Research Foundation grants prestigious awards to 20 top young scientists 7Pilot program to let US high-school students experience Antarctic science at a Chilean station 2
(Date:12/24/2014)... , Dec. 24, 2014  United Therapeutics Corporation (NASDAQ: ... (NYSE: MDT ) has submitted a pre-market ... (FDA) for the use of Medtronic,s SynchroMed ® ... catheter) for use with United Therapeutics, Remodulin ® ...
(Date:12/24/2014)... Texas , Dec. 24, 2014  Vermillion, Inc. ... on gynecologic disease, announced today that the Company ... including Oracle Investment Management, Jack W. Schuler ... Total proceeds were $10.5 million, before offering expenses.  ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market ... (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, ... Forecasts to 2019” provides a detailed overview of ... trends, and strategies impacting the preparative and process ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 Earlier this year ... Sherley, director of the Adult Stem Cell Technology Center, LLC ... under appreciated unique property of adult tissue stem cells. ... the Past, Important for the Future,” embodied the essence of ...
Breaking Biology Technology:United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4
... CHESTNUT HILL, MA -- Boston College researchers have discovered ... enhanced chemical vapor deposition, finding a disorderly tangle of ... the nanoscopic tubes, according to a report in the ... By using a thin layer of catalyst, Professor of ...
... MILFORD, Mass., Oct. 3, 2011 Waters Corporation ... of Minnesota,s Mass Spectrometry Laboratory into its ... Spectrometry Laboratory under the direction of Joseph Dalluge, Ph.D., for ... fibrosis and other diseases. He,s also honored for his research ...
... WASHINGTON, Oct. 3, 2011 Brainlab announced today the ... command and control center for information-guided surgery, is unveiling ... "Curve represents thousands of enhancements based ... feedback has always been a priority for Brainlab and ...
Cached Biology Technology:Boston College Researchers discover 2 early stages of carbon nanotube growth 2Waters Honors University of Minnesota's Joseph Dalluge, Ph.D. and Department of Chemistry Mass Spectrometry Laboratory with Center of Innovation Recognition 2Waters Honors University of Minnesota's Joseph Dalluge, Ph.D. and Department of Chemistry Mass Spectrometry Laboratory with Center of Innovation Recognition 3Waters Honors University of Minnesota's Joseph Dalluge, Ph.D. and Department of Chemistry Mass Spectrometry Laboratory with Center of Innovation Recognition 4Brainlab Launches Newest Innovation in Image Guided Surgery Technology 2Brainlab Launches Newest Innovation in Image Guided Surgery Technology 3
... sequence corresponds to residues 115-133 of rat SAP97. The sequence ... L - P - S - E - R - I ... N - E - V - L - G - P ... conjugation and is not a part of the native rat SAP97 ...
... Have a novel target for which no ... Weve made custom antibodies for a variety of ... be happy to put our technology and expertise ... , Access to our patented RabMAb development technology ...
... SOS Protein Solubility Service, We ... , New SOS technology yields the best ... parameters applied on each clone submitted , ... ,The new protein Solubility Optimization Service ...
... II (Dual-Stage Quadrupole) Thermo Scientific (Part ... in analytical instrumentation, introduces the latest product ... II. Based on the proven reliability and ... GC/MS systems, the DSQ II incorporates the ...
Biology Products: