Researchers develop simple method to create natural dru...(that led to the breakthrough Moore said ...)

Date:9/4/2007

that led to the breakthrough, Moore said the process was achieved incrementally. The time-consuming work was spent beforehand identifying and preparing the enzymes that would ultimately catalyze the synthesis, also known as assembling the biosynthetic pathway.

Weve been preparing for some time now a biological toolbox, said Moore. In this new process the enzymes become the tools to do the synthesis.

An article in Nature Chemical Biology by Robert Fecik of the University of Minnesota indicated that Moore and co-workers have now taken biosynthetic pathway reconstruction to a new level.

The new research also carries the potential to combine certain natural enzymes to produce new molecules that typically cannot be found in nature with the goal of developing new drugs. Moore calls these unnatural natural products.

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Contact: Mario Aguilera, Cindy Clark scrippsnews@ucsd.edu 858-534-3624 University of California - San Diego Source:Eurekalert

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