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Researchers develop novel polymer to help oral medications reach the bloodstream
Date:8/28/2013

n the gastrointestinal tract, it breaks down into things that are part of our diet anyway," said Edgar.

"We are excited by these compounds, and there are companies interested in making the investments to get them approved," Edgar added.

The article in Carbohydrate Polymers, "Synthesis and structure-property evaluation of cellulose omega-carboxyesters for amorphous solid dispersions," describes the successful use of the novel polymers with the anti-HIV drug ritonavir. It is authored by Haoyu Liu of Shanghai, China, a doctoral student studying macromolecular science and engineering in Virginia Tech's College of Natural Resources and Environment; Grace A. Ilevbare, who recently received her doctorate from the College of Pharmacy at Purdue University; Benjamin P. Cherniawski of Afton, Va., a senior majoring in chemistry in Virginia Tech's College of Science at the time of the research; Earl T. Ritchie, an undergraduate chemistry major at Clemson University who conducted summer research with the Macromolecules and Interfaces Institute; Taylor; and Edgar.

A study in the April 18 American Chemical Society journal Molecular Pharmaceutics described how a group of chemically diverse polymers worked to stabilize three structurally different medicines: ritonavir and efavirenz, both used for treating HIV, and celecoxib, used for treatment of arthritis and other painful inflammations. The article was authored by Ilevbare, Liu, Edgar, and Taylor.

The group had previously published research examining a range of commercially available and novel polymers used with ritonavir; resveratrol, which is the beneficial compound in chocolate and red wine; and ellagic acid, the flavonoid in walnuts an
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Contact: Lynn Davis
davisl@vt.edu
540-231-6157
Virginia Tech
Source:Eurekalert

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