Navigation Links
Researchers develop novel polymer to help oral medications reach the bloodstream
Date:8/28/2013

nt drugs more bioavailable through the creation of polymers tailor-made for this purpose."

Many important drugs are like table salt; they crystallize easily. When they do, the crystals are stubbornly difficult to dissolve. They crystallize instead of remaining dispersed, whether in the pill or after release in the digestive tract. Many medicines locked into crystals don't dissolve fast enough to work properly. If that happens, they can't reach their target.

Polymers are introduced to interfere with crystallization. "But the polymers that are presently FDA approved are not effective in meeting all the challenges," said Edgar. "They may prevent a process called nucleation but not stop growth of the crystal if it gets started. Or they may not continue to work after a period of time or if conditions are too hot or too damp. We needed to design a better polymer."

Imagine sugar dissolved in water. If a bit of dust is introduced, it can lead to nucleation the sugar sticks to the dust and then crystal growth. In this example, the polymer would cover the dust mote and repel the sugar molecules, preventing nucleation.

"Stopping nucleation is relatively easy, like stopping a skier before he starts down the hill," said Edgar. "Stopping growth is harder, like trying to stop the skier once he is speeding down the slope. But our polymers can do both stop nucleation and growth."

Edgar and Taylor are working with natural cellulose to create derivatives known as cellulose esters. "They are the polymers used to create LCD screens, automotive paint, and cellophane tape," said Edgar. "Cellulose is an abundant, renewable, completely natural polymer used by nature as the 'steel reinforcing rod' of trees and a major component of all plants."

The Virginia Tech and Purdue groups have discovered that the effective design for pharmaceutical applications is cellulose omega-carboxyesters, which are cellulose esters that the researchers hav
'/>"/>

Contact: Lynn Davis
davisl@vt.edu
540-231-6157
Virginia Tech
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Researchers develop rapid, cost-effective early detection method for organ transplant injury
2. UTHealth, Swedish researchers uncover mystery in blot clotting disorder
3. Researchers develop software tool for cancer genomics
4. Rice, MD Anderson researchers win NIH grant to study protein networks
5. Researchers discover how inhibitory neurons behave during critical periods of learning
6. UCLA researchers invent portable device for common kidney tests
7. Harvard Stem Cell researchers create cells that line blood vessels
8. Researchers figure out why gold nanoparticles can penetrate cell walls
9. Finnish researchers develop quick test kit for detecting phenolic compounds in drinking water
10. BIDMC cardiovascular institute researchers will lead $4 million NIH grant to study micrornas
11. UC Davis researchers discover molecular target for the bacterial infection brucellosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... regulate their symbiotic relationship with soil bacteria by ... plant structure from leaves into the roots to ... roots. This collaborative study was conducted by researchers ... Graduate University for Advanced Studies (SOKENDAI), and the ... , Legumes, an important plant family which ...
(Date:9/18/2014)... Miranda, a small, icy moon of Uranus, is one ... the solar system. Despite its relatively small size, Miranda ... that resulted in the formation of at least three ... coronae. , These coronae are visible in Miranda,s ... km across. Arden corona, the largest, has ridges and ...
(Date:9/18/2014)... "frequent flyers" program, fruit flies surely would be eligible ... increasing numbers of fruit fly research studies. One fruit ... and another is scheduled launch to the station Sept. ... December. , Fruit flies are biomedical research models studied ... organisms can reveal the basis for health and disease ...
Breaking Biology News(10 mins):For legume plants, a new route from shoot to root 2Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Buzzing with activity: Fruit flies orbit Earth for science 2Buzzing with activity: Fruit flies orbit Earth for science 3Buzzing with activity: Fruit flies orbit Earth for science 4
... of the tyrannosaurid, says a University of Alberta researcher ... turn the animal into a "zoological superweapon." , ... tyrannosaurids," said Dr. Eric Snively, a post doctoral research ... instance, was keeping the T. rexes from breaking their ...
... is virus as for example HIV and bird flu able ... the purpose of the virus? Researchers at the University of ... is a collaboration between molecular biologists and physicists. ”The molecular ... the interplay between the intercellular parts, while the physicists have ...
... get older. As sleep quality and quantity typically decrease ... a healthy older man gets can affect his level of ... the April 1st issue of the journal SLEEP. , The ... of Chicago, focused on 12 healthy men between the ages ...
Cached Biology News:Fused nasal bones helped tyrannosaurids dismember prey 2Danish researches solve virus puzzle 2
(Date:9/20/2014)... Texas (PRWEB) September 20, 2014 ... integrated urological and interventional radiology products and services, ... Inc. subsidiary with Clinicon Corporation for ... expands HealthTronics’ portfolio of minimally invasive, mobile, surgical ... patients. , Under the agreement, HealthTronics will make ...
(Date:9/19/2014)... crop yields to disease risks, the biological characteristics people ... Just as for heightthe textbook example of a complex ... shaped by multiple genetic and environmental influences, making it ... such genes, geneticists typically mate two individuals that differ ... small mouseand then study their descendents, looking for genes ...
(Date:9/19/2014)... California (PRWEB) September 19, 2014 ... and its potential to revolutionize the world has ... multinational corporations and small start-ups. The early years ... research projects largely due to the high risks ... Government budgets earmarked for this evolving technology have ...
(Date:9/19/2014)... 19, 2014  Nektar Therapeutics (NASDAQ: ... characterizing the analgesic profiles of a series of ... agonist molecules. The preclinical research candidates were created ... The analgesic properties of kappa receptor ... 1,2 Kappa opioid receptors are expressed in ...
Breaking Biology Technology:HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 2HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 3Want to link genes to complex traits? Start with more diversity 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5
... /PRNewswire-FirstCall/ - Oncolytics Biotech Inc.,("Oncolytics") (TSX:ONC, NASDAQ:ONCY) ... Administration (FDA) review, the Company is initiating ... administration of REOLYSIN(R) in,combination with paclitaxel and ... cancers. The Principal Investigator is Dr. Monica ...
... but powerful engine that propels the bacterium Bacillus ... flagellum by a protein clutch, Indiana University Bloomington and ... this week,s Science . , Scientists have ... what causes the flagellum to stop spinning -- temporarily ...
... As President Of ... AeroLEF Division -, ... , TSX: YM, AIM: YMBA), an oncology company that identifies,develops and ... imposed by the US Food and Drug,Administration (FDA) on the development ...
Cached Biology Technology:Oncolytics Biotech Inc. Announces U.S. Phase 2 Clinical Trial Investigating REOLYSIN(R) in Combination with Paclitaxel and Carboplatin 2Oncolytics Biotech Inc. Announces U.S. Phase 2 Clinical Trial Investigating REOLYSIN(R) in Combination with Paclitaxel and Carboplatin 3Microscopic 'clutch' puts flagellum in neutral 2Microscopic 'clutch' puts flagellum in neutral 3YM BIOSCIENCES ANNOUNCES FDA LIFTS CLINICAL HOLD ON AEROLEF(R) AND CLEARANCE OF A PHASE II CLINICAL TRIAL 2YM BIOSCIENCES ANNOUNCES FDA LIFTS CLINICAL HOLD ON AEROLEF(R) AND CLEARANCE OF A PHASE II CLINICAL TRIAL 3