Navigation Links
Researchers develop novel molecular blood group typing technique
Date:4/9/2014

Philadelphia, PA, April 10, 2014 Scientists in France have designed a new system for molecular blood group typing that offers blood banks the possibility of extensive screening of blood donors at a relatively low cost. Their approach is described in the current issue of The Journal of Molecular Diagnostics.

Although blood transfusion is generally safe, alloimmunization (when an antibody is formed in response to an antigen that is not present on a person's own red blood cells [RBCs]) remains a dreaded complication, particularly in patients with sickle cell diseases.

"This may cause problems, ranging from delayed hemolytic transfusion reaction to difficulty in obtaining matched RBCs. Where patients have alloantibodies, producing a sufficient quantity of extensively typed blood units will never be feasible using conventional serologic donor screening methods," explains lead investigator Jean-Charles Brs, PhD, of the Etablissement Franais du Sang Pyrnes Mditerrane, Montpellier.

The standard technique, conventional hemagglutination, is a lengthy procedure and involves only a limited range of antigen testing. In this antibody-based agglutination, RBCs suspended in liquid collect into clumps when bound by the antigen-specific antibody. Dr. Brs adds, "In the French Blood Service, the Etablissement Franais du Sang (EFS), blood donation qualification laboratories test all blood donations for A, B, O, Rhesus (RH1), and KEL (KEL1) blood groups, but only 5% to 10% of donations are tested for other clinically significant antigens."

The investigators therefore developed a new flexible DNA microarray platform for molecular blood group typing. This includes two robotic workstations that allow processing from blood sample to the genotype. A pilot study shows promising results for responding to blood donor laboratories' requirements for simple, low-cost screening.

For small batch production, the cost of genotyping, includi
'/>"/>

Contact: Eileen Leahy
mdmedia@elsevier.com
732-238-3628
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover how the kissing disease virus hijacks human cells
2. Researchers say Neanderthals were no strangers to good parenting
3. UNC researchers show how cancer cells may respond to mechanical force
4. Dartmouth researchers identify potential therapeutic target for deadly brain cancer
5. Researchers find arid areas absorb unexpected amounts of atmospheric carbon
6. Researchers receive $1.14 million to study threats to honey bees
7. Swedish researchers show impact of long-term vitamin D insufficiency on fracture risk
8. Guelph researchers solve part of hagfish slime mystery
9. Researchers design trees that make it easier to produce paper
10. Researchers manipulate tiny objects with ultrasound
11. UCSB researchers create first regional Ocean Health Index
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... , June 17, 2015 QIAGEN ... launched new Investigator ® STR assay kits for analysis ... United States . The new genetic fingerprint kits provide ... (short tandem repeats or STRs) for DNA matching. They incorporate ... of DNA in each sample, a novel QIAGEN technology that ...
(Date:6/16/2015)... 2015 /CNW Telbec/ - handyem Inc. and FlowMetric ... incorporation of handyem,s HPC-150 portable flow cytometer within ... This unprecedented model of mobile laboratory platform is ... Pennsylvania Convention Center, ... to 18 th 2015.  By virtue ...
(Date:6/16/2015)... GOTHENBURG, Sweden , June 16, 2015 ... 2015 from previously communicated that it will amount to at ... 390 MSEK. Due to the rapid increase in market growth ... from the previously communicated guidance that revenue for 2015 will ... 2015 will amount to approximately 2,200 MSEK. Due ...
Breaking Biology News(10 mins):QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3
... University of Miami (UM) Rosenstiel School of Marine & Atmospheric ... show that strong links between the corals reefs of the ... key to preserving fish and marine resources in the Asia-Pacific ... Cowen and colleagues from the ARC Centre of Excellence for ...
... collect large amounts of high quality data on climate ... the economic and climate models do not always have ... million grant from the Department of Energy, the on-the-ground ... State Institutes of Energy and the Environment. The ...
... of all Americans will have diabetes or pre-diabetes by the ... online in the FASEB Journal ( http://www.fasebj.org ) ... evolutionary "wrong turn." In the research report, scientists show that ... gene called "CMAH" may make humans more prone to obesity ...
Cached Biology News:New study shows marine 'networks' can protect fish stocks 2DOE grant joins climate modeling with local, regional empirical data 2New research suggests that obesity and diabetes are a downside of human evolution 2
(Date:7/2/2015)... ... 03, 2015 , ... Cuvettes have been used in countless labs for decades. In the ... they needed. As expected, this was a daunting and tiring process looking at endless ... were not able to navigate the complex catalog structure. , Now thanks to FireflySci, scientists ...
(Date:7/2/2015)... Scotland , July 2, 2015 ... Bio-tech procurement company Amici Procurement has chosen ... to help it move to Office 365. ... provides small to medium-sized companies in the bio-tech ... all aspects of the purchasing cycle to help them ...
(Date:7/1/2015)... ... 01, 2015 , ... It is now possible to separate two common disorders: ... computed tomography (SPECT) according to researchers from Amen Clinics, UCLA, Thomas Jefferson University, ... and is believed to be the largest brain imaging study ever, will be published ...
(Date:7/1/2015)... ... ... The next-generation sequencing (NGS) clinical market is poised for huge growth as ... Research reveals in its new report that the market drivers of this vibrant industry ... for better diagnostics as part of a molecular diagnostics trend. , The global market ...
Breaking Biology Technology:New Cuvette E-Commerce Website Launched by FireflySci 2Biotech Procurement Company Moves to Office 365 with iomart 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 3
... HOUSTON, April 23, 2012  Melanie Pita, J.D., will ... records journey for rural hospitals as she presents ... Rural Health Association,s Annual Conference, being held  April ... in Effingham, Ill.   During the ...
... Ahram Biosystems, Inc., a leading innovator of new life ... the economy model of its innovative portable PCR system. The ... PCR amplification with high speed and sensitivity in a fully ... provides three " Standard Fast" speed levels delivering 30-cycle ...
... American Telemedicine Association is pleased to host the ATA ... San Jose, California ( www.ata2012.com ).  ATA 2012 is ... aspects of telemedicine, telehealth, mHealth and remote healthcare technology. ... you,re a seasoned professional, ATA 2012 provides the information ...
Cached Biology Technology:Prognosis HIS Executive Slated To Offer EHR Advice At Illinois Rural Health Association Conference 2Ahram Biosystems Announces Launch of the New Economy Model F1-12 of Its Palm PCR Series 2Free Expo-Hall Passes for ATA 2012 2
From formula-fed bovine calves Sterile, Cell culture tested...
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
... samples may be carried out using this ... attention. System control and data processing is ... The elegant, powerful and very easy to ... 98 and 2000., The supplied automatic sample injector ...
Heavy-duty rim. Especially recommended as a titration flask. Corning5100. capacity 250 mL Special grade: student grade...
Biology Products: