Navigation Links
Researchers develop new method for creating tissue engineering scaffolds

Researchers at Northwestern University have developed a new method for creating scaffolds for tissue engineering applications, providing an alternative that is more flexible and less time-intensive than current technology.

A paper describing the results, "Low-Pressure Foaming: A Novel Method for the Fabrication of Porous Scaffolds for Tissue Engineering," was featured in the February issue of the journal Tissue Engineering.

Through tissue engineering, researchers seek to regenerate human tissue, such as bone and cartilage, that has been damaged by injury or disease. Scaffolds artificial, lattice-like structures capable of supporting tissue formation are necessary in this process to provide a template to support the growing cells. Over time, the scaffold resorbs into the body, leaving behind the natural tissue.

Scaffolds are typically engineered with pores that allow the cells to migrate throughout the material. The pores are often created with the use of salt, sugar, or carbon dioxide gas, but these additives have various drawbacks; They create an imperfect pore structures and, in the case of salt, require a lengthy process to remove the salt after the pores are created, said Guillermo Ameer, professor of biomedical engineering at the McCormick School of Engineering and professor of surgery at the Feinberg School of Medicine.

The new scaffolds, created from a combination of ceramic nanoparticles and elastic polymers, were formed in a vacuum through a process termed "low-pressure foaming" that requires high heat, Ameer said. The result was a series of pores that were highly interconnected and not dependent on the use of salt.

The new process creates scaffolds that are highly flexible and can be tailored to degrade at varying speeds depending on the recovery time expected for the patient. The scaffolds can also incorporate nano-sized fibers, providing a new range of mechanical and biological properties, Ameer said.

"The technology could prove very useful in repairing ACL (anterior cruciate ligament) tears and in bone void fillers," Ameer said.


Contact: Pat Vaughan Tremmel
Northwestern University

Related biology news :

1. No entry without protein recycling: RUB researchers discover new coherence in enzyme transport
2. Biodiversity enhances ecosystems global drylands -- Ben-Gurion U researchers
3. Boston University researchers develop novel drug delivery system
4. MSU researchers show how new viruses evolve, and in some cases, become deadly
5. Researchers show how viruses evolve, and in some cases, become deadly
6. Berkeley Lab researchers discover critical rotational motion in cells
7. CU School of Medicine researchers look at effects of 2 common sweeteners on the body
8. Researchers develop gene therapy that could correct a common form of blindness
9. Researchers meet to refine carbon budget for US East Coast
10. Penn researchers help solve questions about Ethiopians high-altitude adaptations
11. Notre Dame researchers report fundamental malaria discovery
Post Your Comments:
(Date:11/10/2015)... Nov. 10, 2015  In this report, ... basis of product, type, application, disease indication, ... this report are consumables, services, software. The ... safety biomarkers, efficacy biomarkers, and validation biomarkers. ... are diagnostics development, drug discovery and development, ...
(Date:11/2/2015)... , Nov. 2, 2015  SRI International has ... to provide preclinical development services to the National Cancer ... SRI will provide scientific expertise, modern testing and support ... of preclinical pharmacology and toxicology studies to evaluate potential ... --> The PREVENT Cancer Drug Development Program is ...
(Date:10/29/2015)... 2015  Connected health pioneer, Joseph C. Kvedar ... technology-enabled health and wellness, and the business opportunities that ... The Internet of Healthy Things . Long before ... existed, Dr. Kvedar, vice president, Connected Health, Partners HealthCare, ... moving care from the hospital or doctor,s office into ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... Jose, CA (PRWEB) , ... ... ... Content Intelligence Company, today announced tighter software integration with MarkLogic, the Enterprise ... where organizations maximize information to drive change. , Smartlogic’s Content Intelligence capabilities ...
(Date:11/27/2015)... ... 27, 2015 , ... Pittcon is pleased to announce the ... in symposia, oral sessions, workshops, awards, and posters. The core of the ... such as, but not limited to, biotechnology, biomedical, drug discovery, environmental, food science, ...
(Date:11/25/2015)... 2015 --> ... - 2020 report analyzes that automating biobanking workflow ... in long-term samples, minimizing manual errors, improving the ... manual errors such as mislabeling or inaccurate sample ... plays a vital role in blood fractionation, DNA ...
(Date:11/25/2015)... HOLLISTON, Mass. , Nov. 25, 2015 ... a biotechnology company developing bioengineered organ implants for life-threatening ... will present at the LD Micro "Main Event" investor ... PT. The presentation will be webcast live and posted ... also be available at the conference for one-on-one meetings ...
Breaking Biology Technology: