Navigation Links
Researchers develop new method for analyzing cell function
Date:6/26/2012

Researchers in Finland and Germany have developed an open-source software that will make it significantly easier to process bioimaging data. The software, named BioImageXD, will help in analysing cell and tissue functions. The work to develop the software has been funded by the Academy of Finland (through the FinNano Research Programme), the European Union and Tekes the Finnish Funding Agency for Technology and Innovation. Version 1.0 of BioImageXD has been accepted for publication in Nature Methods, the top journal in the field.

Among other things, the BioImageXD software is a tool for analysing how molecules move on cell surfaces and how they bond together. With the software, scientists can analyse the composition of cell surfaces, study how cancer cells spread in a three-dimensional environment, or measure how effectively viruses and targeted drugs enter cells. Such calculations have not been possible before.

In recent years, cell and tissue imaging with new, specialised microscopes has considerably advanced research in bioscience and biomedicine. The new methods also allow for studies on living cells. However, the microscopic images are not displayable as such and need to be rendered into three-dimensional models. These 3D renderings carry significant weight as evidence already by themselves, but reliable scientific data also requires numerical values, which can then be used in mathematical calculations. In addition, these calculations must be feasible with extremely large datasets.

So far, the lack of suitable software has clogged up this development. To solve the problem, researchers in Turku, Jyvskyl and Dresden drew up precise specifications for software for processing of imaging data. A key criterion was that the software would be based on the principles of open source, freely available to all researchers.

The work resulted in BioImageXD, a software program that thanks to its versatile and open-source nature has received much positive feedback from hundreds of researchers around the world.

From extensive development to test success

One of the unique features of BioImageXD is that it can be used to create completely new analysis methods (and users do not even need programming skills), process thousands of images at the same time and analyse millions of molecules. Comparison tests have shown that BioImageXD is faster and more sensitive than other similar programs.

The development of the BioImageXD software began ten years ago in a University of Jyvskyl research team led by Jyrki Heino. Since then, the work has continued through active collaboration between Heino's team, Varpu Marjomki's team and Daniel White from Max Planck Institute of Molecular Cell Biology and Genetics.

The main development has been led by Pasi Kankaanp, who now works at Turku Centre for Biotechnology as Coordinator of the Cell Imaging Core.

The BioImageXD software will be featured in a special issue of Nature Methods, focusing on the processing of biomedical images.


'/>"/>

Contact: Pasi Kankaanp
pkanka@utu.fi
358-405-221-090
Academy of Finland
Source:Eurekalert

Related biology news :

1. Maths formula leads researchers to source of pollution
2. 7 pharmaceutical companies join academic researchers to speed TB drug discovery
3. Researchers advance biometric security
4. Argonne researchers receive 4 R&D 100 awards
5. Researchers identify need to sample multiple tumor zones in breast cancer
6. London researchers discover novel mechanism involved in key immune response
7. NTU researchers study little mighty creature for scientific breakthrough
8. UTMB researchers create powerful new method to analyze genetic data
9. Researchers at GW receive federal funds to study the effect earthquakes have on nuclear reactors
10. Stanford researchers help predict the oceans of the future with a mini-lab
11. Researchers complete the first epigenome in Europe
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2016)... -- As part of its longstanding mission to improve genetic literacy ... released its latest children,s book, titled The One ... topics of inheritance and variation of traits that are part ... school classrooms in the US. The book ... Killoran , whose previous book with 23andMe, You ...
(Date:12/16/2016)... 2016   IdentyTechSolutions America LLC , a ... solutions and a cutting-edge manufacturer of software and ... offering seamless, integrated solutions that comprise IDT biometric ... solutions provide IdentyTech,s customers with combined physical identification ... crime and theft. "We are proud ...
(Date:12/15/2016)... ... has announced the addition of the "Global Military Biometrics Market 2016-2020" ... global military biometrics market to grow at a CAGR of 7.5% during ... on an in-depth market analysis with inputs from industry experts. The report ... The report also includes a discussion of the key vendors operating in ...
Breaking Biology News(10 mins):
(Date:1/16/2017)... ... January 16, 2017 , ... Appellate Court of ... on the appeal filed by India-based Dishman Pharmaceutical & Chemical Ltd. company (DPCL) ... and one of its Dishman Group’s 100% wholly owned New Jersey-based subsidiary Dishman ...
(Date:1/16/2017)... ... 16, 2017 , ... Attagene , a Research Triangle ... Small Business Administration. The Tibbetts Award honors the Small Business Innovation Research ... are considered the best of the best from the thousands of firms that ...
(Date:1/14/2017)... , ... January 14, 2017 , ... ... new service providing complete end-to-end genome assemblies to researchers around the globe. ... a major obstacle in answering a wide range of scientific questions. The ...
(Date:1/13/2017)... 2017 Research and Markets has announced the ... Global Forecast to 2021" report to their offering. ... The biosimilars market is ... Billion in 2016, at a CAGR of 26.3%. ... manufacturing type, and application. Factors such as rising incidence of various ...
Breaking Biology Technology: