Navigation Links
Researchers develop new, more-sensitive assay for detecting DNA methylation in colon cancer
Date:8/16/2009

e in colonoscopy based screening for the disease," explained Markowitz. "Additionally, 10 percent of colon cancers develop in young individuals, age less than 50. These persons are currently largely excluded from colonoscopy based screening. Hopefully, an inexpensive noninvasive screening test such as Methyl-BEAMing will provide a way to offer screening for younger individuals also."

Even though the blood test only catches roughly 60 percent of colon cancers, researchers argue this is comparable to mammograms a widely accepted screening method that ultimately leads to a more invasive follow-up procedure.

"A positive mammogram leads on to a biopsy. A positive Methyl-BEAMing test would lead on to a colonoscopy," said Dr. Markowitz.

Researchers say that in addition to being used as a screening method in younger individuals or those who are unwilling or unable to have colonoscopies, the blood test can be used in between colonoscopies, and for monitoring of the disease after therapy. Furthermore, Markowitz believes that the discovery of additional colon cancer markers will further improve the value of the test.

"We anticipate that the Methyl-BEAMing test will be improved by testing for a panel of gene DNAs that become methylated in colon cancers. So far we have identified the vimentin gene as a DNA that gets methylated in most, but not all, colon cancers. We are working on discovering additional genes that become methylated in the remaining group of colon cancers that are not detected by the vimentin test," continued Dr. Markowitz.

Future applications of the blood test are not limited to colon cancers. The same technique could be applied to the detection of other cancers, or for pre-natal testing of diseases, like downs syndrome for which altered methylation is a hallmark of the disease.


'/>"/>

Contact: Christina DeAngelis
christinadeangelis@case.edu
216-368-3635
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... 18-22, 2014 , WHERE: , San Diego ... CA 92101 , WHAT: , Invited and ... latest research in human genetics. Examples of sessions ... on rare genetic variants in health and disease, ... sun sensitivity (Saturday, Oct. 18, 5:30-7:30 pm) , ...
(Date:8/21/2014)... La. A team of researchers at ... method for using affordable, consumer-grade 3D printers ... that can contain antibacterial and chemotherapeutic compounds ... comprised of doctoral students and research faculty ... engineering programs collaborated to create filament extruders ...
(Date:8/21/2014)... the pancreas digesting itself resulting in severe abdominal pain, ... around 20,000 patients are diagnosed with the disease resulting ... treatment is restricted to intravenous fluid and nutritional support. ... Life Sciences, who led the research, said "The major ... stones and excessive alcohol intake combined with a high ...
Breaking Biology News(10 mins):American Society of Human Genetics 2014 Annual Meeting 2Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3Insulin offers new hope for the treatment of acute pancreatitis 2
... Software, the Uniformed Service University of the Health ... the Advancement of Military,Medicine, Inc. (HJF) have entered ... extend their collaborative endeavors in prostate disease,research. The ... differentiate patients with,favorable versus poor prognosis at the ...
... Research, which is strategically funded by BBSRC, is ... bacterial cells to combat potentially dangerous microbial infections. ... bacteria, and IFR has been studying one that ... dangerous source of hospital-acquired infections. New research is ...
... Weizmann Institute scientists have added a significant piece to the ... size as an embryo or organism grows and develops. In ... Naama Barkai and Ben-Zion Shilo and research student Danny Ben-Zvi ... in developing fruit fly wings in which the vein ...
Cached Biology News:Genomatix, USU and HJF execute a CRADA: Prostate cancer prognostic marker discovery by NGS 2Tuning natural antimicrobials to improve their effectiveness at battling superbugs 2Scale models 2
(Date:8/20/2014)... measuring vibrational motion of a single molecule with a ... a single molecule differs from the behaviour of larger ... the University of California, Irvine, where post-doctoral researcher Eero ... visiting fellow under professor Vartkess A. Apkarian, whose team ... by Professor Eric O. Potma. The results of the ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 The ... is being held on October 29-30 in San Francisco, ... industry, academic and government researchers and clinicians focused on ... space. , In the twelve years since the ... therapies have been introduced with pharmacogenetic information in the ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 ... released today including improvements to the enterprise replication ... connectors for Lucene, SOLR and Elasticsearch. This release ... this high performance triplestore – GraphDB™ was formerly ... in deploying the only mature enterprise resilient RDF ...
(Date:8/19/2014)... Cellgen Diagnostics today ... fund a corporate lab for its genetic-based medical ... is a critical component in the move from ... implementation of personalized medicine – a more predictive, ... Indiegogo contributions will support Cellgen’s intent to develop ...
Breaking Biology Technology:Seeing a molecule breathe 26th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3
... ARNA ) announced today that the company is ... Conference on September,11, 2007 at 3:30 p.m. Eastern Time ... New York City. Jack Lief, Arena,s President and Chief,Executive ... the,company and its clinical development and discovery programs. ...
... Pieris AG,a bio-pharmaceutical company developing Anticalins(R), a ... announced successful completion,of a series of preclinical ... disease. The studies reported by Pieris ... VEGF is a key factor in the ...
... the friendly bacteria beloved of yoghurt advertisers, may be ... giving us safer pork products, according to scientists speaking ... General Microbiologys 161st Meeting at the University of Edinburgh, ... from the UKs Veterinary Laboratories Agency in Weybridge, Surrey ...
Cached Biology Technology:Arena Pharmaceuticals to Present at the Bear Stearns 20th Annual Healthcare Conference 2Arena Pharmaceuticals to Present at the Bear Stearns 20th Annual Healthcare Conference 3Probiotic good bugs may control gut infections 2
... kit contains 5 ml CELLection Dynabeads (4.5 ... the human epithelial antigen EpCAM and DNase ... log enrichment of epithelial tumour cells directly ... cells clumps can be enriched from bone ...
nucleophosmin (nucleolar phosphoprotein B23, numatrin), mRNA...
Human PDGF R beta MAb (Clone # PR7212)...
... Ambion's ActivePro In Vitro ... an E.coli lysate, synthesizes ... as well as proteins ... than competing kits. This ...
Biology Products: