Navigation Links
Researchers develop nano-sized 'cargo ships' to target and destroy tumors
Date:9/11/2008

the development. "These drugs don't have the capability to avoid the body's natural defenses or to discriminate their intended targets from healthy tissues. In addition, we lack the tools to detect diseases such as cancer at the earliest stages of development, when therapies can be most effective."

The researchers designed the hull of the ships to evade detection by constructing them of specially modified lipids--a primary component of the surface of natural cells. The lipids were modified in such a way as to enable them to circulate in the bloodstream for many hours before being eliminated. This was demonstrated by the researchers in a series of experiments with mice.

The researchers also designed the material of the hull to be strong enough to prevent accidental release of its cargo while circulating through the bloodstream. Tethered to the surface of the hull is a protein called F3, a molecule that sticks to cancer cells. Prepared in the laboratory of Erkki Ruoslahti, a cell biologist and professor at the Burnham Institute for Medical Research at UC Santa Barbara, F3 was engineered to specifically home in on tumor cell surfaces and then transport itself into their nuclei.

"We are now constructing the next generation of smart tumor-targeting nanodevices," said Ruoslahti. "We hope that these devices will improve the diagnostic imaging of cancer and allow pinpoint targeting of treatments into cancerous tumors."

The researchers loaded their ships with three payloads before injecting them in the mice. Two types of nanoparticles, superparamagnetic iron oxide and fluorescent quantum dots, were placed in the ship's cargo hold, along with the anti-cancer drug doxorubicin. The iron oxide nanoparticles allow the ships to show up in a Magnetic Resonance Imaging, or MRI, scan, while the quantum dots can be seen with another type of imaging tool, a fluorescence scanner.

"The fluorescence image provides higher
'/>"/>

Contact: Kim McDonald
kimmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Gap junction protein vital to successful pregnancy, researchers find
2. Cortisol and fatty liver: Researchers find cause of severe metabolic disorders
3. Researchers seeking to identify Alzheimers risk focus on specific blood biomarker
4. ISU researchers help map first plant-parasitic nematode genome sequence
5. Collaboration between researchers yields more comprehensive portrait of brain cancer
6. Tel Aviv University researchers create new stem cell screening tool
7. Hopkins researchers piece together gene network linked to schizophrenia
8. TGen and Washington University researchers discover new approach to treating endometrial cancer
9. Researchers devise means to create blood by identifying earliest stem cells
10. Researchers discover atomic bomb effect results in adult-onset thyroid cancer
11. Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers develop nano-sized 'cargo ships' to target and destroy tumors
(Date:7/27/2014)... largest prevalence studies to date, researchers from the U.K. ... the hepatitis C virus (HCV). Findings published in Hepatology, ... of Liver Diseases, indicate that genotype 1 is the ... of which one-third reside in East Asia. Genotype 3, ... most prevalent, followed by genotypes 2, 4, 6, and ...
(Date:7/27/2014)... the potential for global climate change to cut food ... ignored the interactions between increasing temperature and air pollution ... crops. , A new study involving researchers at MIT ... that policymakers need to take both warming and air ... study looked in detail at global production of four ...
(Date:7/27/2014)... patients, scientists have identified more than two dozen ... six that had not been previously reported. The ... partially funded by the National Institutes of Health ... laboratories. , "Unraveling the genetic underpinnings of Parkinson,s ... in this complex disease, and hopefully, may one ...
Breaking Biology News(10 mins):Hepatitis C virus genotype 1 is most prevalent worldwide 2Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3NIH scientists find 6 new genetic risk factors for Parkinson's 2
... temperatures and the ability to conserve water for long periods ... arid parts of the world. But is this global ... the open-access, peer-reviewed journal PLoS ONE April 9, ... Haifa, Israel now show that this is indeed the case, ...
... Calif., April 9, 2009Scientists at Burnham Institute for Medical ... (UC San Diego) School of Medicine have demonstrated in ... the immune system when encapsulated in polytetrafluorethylene (PTFE). The ... 1 diabetes, was published online on April 8 in ...
... if you stare at the downward motion of a waterfall ... appear to drift upward. MIT neuroscientists have found that ... visual perception but also in our tactile perception, and that ... you feel the world can actually change how you see ...
Cached Biology News:Scorpion biodiversity 2Device protects transplanted pancreatic cells from the immune system 2MIT: How you feel the world impacts how you see it 2
(Date:7/28/2014)... (PRWEB) July 28, 2014 The National ... in Muncie IN, is pleased to announce that it ... National Museum of the United States Air Force. , ... year-long process that concluded this spring with an on-site ... Dayton, OH museum. , The National Museum of ...
(Date:7/25/2014)... 2014 "Ischemic Stroke and Cerebral ... data on the Ischemic Stroke and Cerebral Stroke ... and data relating to the clinical trials on ... global Ischemic Stroke Research Report 2014 at: ... the trial numbers and their recruitment status as ...
(Date:7/25/2014)... -- Trillions of bacteria live in each person,s digestive ... digest food and stave off harmful infections, but their ... To help shed light on the role of these ... professor Eric Alm recently tracked fluctuations in the bacterial ... The findings, described in the July 25 issue of ...
(Date:7/25/2014)... 25, 2014 Research and Markets ... Metabolomics Market 2014-2018" report to their offering. ... Metabolomics or Metabonomics is the scientific study ... a new experimental technique that is being widely ... Metabolites are small molecules that are present in ...
Breaking Biology Technology:AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2
... DIEGO, Nov. 2, 2010 Ardea Biosciences, Inc. (Nasdaq: ... been awarded a $733,438 grant from the Department of ... Patient Protection and Affordable Care Act.  Ardea submitted three ... active development, for expenses incurred during 2009 and 2010. ...
... 2010 Vaccinex, Inc. announced today that it has ... under the Qualifying Therapeutic Discovery Project (QTDP) Program to ... monoclonal antibodies, VX15, VX5 and VX35.  The QTDP grant ... by the U.S. Department of Health and Human Services ...
... ... ... var shortURL = ""; BitlyCB.alertResponse = ... the first one. for (var r in data.results) { first_result = data.results[r]; break; } for (var key in first_result) ...
Cached Biology Technology:Ardea Biosciences Awarded a $733,438 Grant from the U.S. Government Under the Patient Protection and Affordable Care Act 2Ardea Biosciences Awarded a $733,438 Grant from the U.S. Government Under the Patient Protection and Affordable Care Act 3NEURO-BIOTECH CORPORATION: Updates and latest developments 2NEURO-BIOTECH CORPORATION: Updates and latest developments 3NEURO-BIOTECH CORPORATION: Updates and latest developments 4NEURO-BIOTECH CORPORATION: Updates and latest developments 5NEURO-BIOTECH CORPORATION: Updates and latest developments 6NEURO-BIOTECH CORPORATION: Updates and latest developments 7NEURO-BIOTECH CORPORATION: Updates and latest developments 8NEURO-BIOTECH CORPORATION: Updates and latest developments 9
... The Mini-PROTEAN 3 Dodeca cell with multi-casting ... of up to 12 mini format handcast (8.3 ... cm) gels. The cell requires 3.4-4.4 L of ... cooling coil that attaches to an external refrigerated ...
...
... has been developed to significantly increase the ... Stability is increased at room temperature ... This product is subjected to 0.2 ... azide. This formulation insures consistently high ...
...
Biology Products: