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Researchers develop more effective way to discover and test potential cancer drugs
Date:11/13/2011

ted compounds showed antitumor activity, and some blocked tumor growth more effectively than current, FDA-approved antiangiogenic drugs.

This screening platform also ensures that researchers do not precondition the system to a known target. "We sometimes assume we know a lot about how these tumor systems work and what we should target," said Zudaire.

The researchers proposed that most of the therapeutically relevant information in pathological systems rests on the complex interactions between the different components of the system rather than on the components themselves. Interrogating these systems in an unbiased manner will reveal not only single molecular targets but unknown interactions between them, which are relevant for the disease.

Ultimately, using this type of phenotypic platform can make drug development more efficient and cost-effective.

"If we improve the initial phases of drug discovery, we can decide where to invest time and money on drugs that are a lot more likely to work," Zudaire said. "This study is proof of principle that the platform works. From here, we can design assays that are more complex and better able to describe what the in-vivo situation will be."


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Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

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