Navigation Links
Researchers develop model of 'near-optimal' genetic code
Date:8/28/2013

Researchers have created a model that may explain the complexities of the origins of life. Their work, which appears in the Journal of the Royal Society Interface, offers new insights into how RNA signaling likely developed into the modern "genetic code."

"Our model shows that today's genetic code probably resulted from a combination of selective forces and random chance," explained Justin Jee, a doctoral student at NYU School of Medicine and the paper's lead author.

The study's other co-authors included: Bud Mishra, who has appointments at NYU's Courant Institute of Mathematical Sciences and the Sackler Institute of Graduate Biomedical Sciences at NYU School of Medicine; Andrew Sundstrom of the Courant Institute; and Steven Massey, an assistant professor in the University of Puerto Rico's Department of Biology.

The researchers sought to account for the composition of the genetic code, which allows proteins to be built from amino acids with high specificity based on information stored in a RNA or DNA genome. This translation process between the nucleic acids and amino acids is remarkably and mysteriously universal; the same code is shared in all organisms from bacteria to human beings. At the same time, the genetic code is nearly, but not completely, optimal in terms of how "good" it is at specifying particular amino acids for particular nucleic acid sequences.

Since the code's discovery in the 1960's, researchers have wondered: how is it that a near-optimal code became so universal?

To address this question, the researchers created a model of genetic code evolution in which multiple "translating" RNAs and "genomic" RNAs competed for survival. Specifically, the translating RNAs were able to link amino acids together based on information stored in genomic RNA, but with varying levels of specificity.

In running computer simulations of RNA interactions, they could see two phenomena. First, it was necessary for the translating and genomic RNAs to organize into cells, which aided the coordination of a code between the translating and genomic RNAs. Second, selective forces led a single set of translating RNAs to dominate the population. In other words, the emergence of a single, universal, near-optimal code was a natural outcome of the model. Even more remarkably, the results occurred under realistic conditionsspecifically, they held under parameters such as protein lengths and rates of mutation that likely existed in a natural RNA world.

"The most elegant ideas in this paper are rather obvious consequences of a well-studied model based on sender-receiver games," noted Mishra, the paper's senior author. "Yet the results are still very surprising because they suggest, for example, that proteins, the most prized molecules of biology, might have had their origin as undesirable toxic trash. Other studies based on phylogenomic analysis seem to be coming to similar conclusions independently."


'/>"/>

Contact: James Devitt
james.devitt@nyu.edu
212-998-6808
New York University
Source:Eurekalert

Related biology news :

1. Researchers develop novel polymer to help oral medications reach the bloodstream
2. Researchers develop rapid, cost-effective early detection method for organ transplant injury
3. UTHealth, Swedish researchers uncover mystery in blot clotting disorder
4. Researchers develop software tool for cancer genomics
5. Rice, MD Anderson researchers win NIH grant to study protein networks
6. Researchers discover how inhibitory neurons behave during critical periods of learning
7. UCLA researchers invent portable device for common kidney tests
8. Harvard Stem Cell researchers create cells that line blood vessels
9. Researchers figure out why gold nanoparticles can penetrate cell walls
10. Finnish researchers develop quick test kit for detecting phenolic compounds in drinking water
11. BIDMC cardiovascular institute researchers will lead $4 million NIH grant to study micrornas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... SAN FRANCISCO and BANGALORE, India ... part of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... service provider, today announced a global partnership that ... convenient way to use mobile banking and payment services. ... Mobility is a key innovation area for financial services, but ...
(Date:4/26/2016)... India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a product ... and Onegini today announced a partnership to integrate ... solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... to provide their customers enhanced security to access ...
(Date:4/19/2016)... -- The new GEZE SecuLogic access control ... system solution for all door components. It can be ... interface with integration authorization management system, and thus fulfills ... dimensions of the access control and the optimum integration ... considerable freedom of design with regard to the doors. ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in Ancona ... or pleural mesothelioma. Their findings are the subject of a new article on the ... are signposts in the blood, lung fluid or tissue of mesothelioma patients that can ...
(Date:6/23/2016)... ... 2016 , ... UAS LifeSciences, one of the leading manufacturers ... Probiotics, into Target stores nationwide. The company, which has been manufacturing high quality ... list of well-respected retailers. This list includes such fine stores as Whole Foods, ...
(Date:6/23/2016)... - FACIT has announced the creation of a ... Propellon Therapeutics Inc. ("Propellon" or "the Company"), to ... of first-in-class WDR5 inhibitors for the treatment of ... an exciting class of therapies, possessing the potential ... patients. Substantial advances have been achieved with the ...
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
Breaking Biology Technology: